Diseases of the urinary tract will no longer be of concern if there is a Palin drug in the medicine cabinet. It operates quickly and efficiently. The result is noticeable after the first application. Analogue "Palina" "Furadonin" acts in a similar way, but has another active ingredient in the composition.
Composition and form of the drug
The drug "Palin" is produced in the form of capsules, tablets and suppositories. The active substance of the drug is pipemidic acid. In capsules it contains 200 mg, in tablets 400 mg, and in suppositories 200 mg.
Capsules are packed in a blister for 10 pieces. There are two blisters in the carton. Tablets are packed in plastic bottles of 20 pieces. There is one bottle in the box. Vaginal candles are packed in 10 pieces in creaks. In the package of cardboard 1 creak.
Analog "Palina" "Ofloxacin" is produced not only in the form of tablets, but also in the form of an ointment, a solution for infusions.
"Palin" is an antibacterial medicine and belongs to the group of quinolones. Active against Gram-negative bacteria, such as:
- Pseudomonas aeruginosa.
- Proteus vulgaris.
- Klebsiella pneumonia.
- Proteus mirabilis.
- Escherichia coli.
- Neisseria spp.
- Enterobacter spp.
Another drug effectively acts against Gram-positive bacteria, for example Staphylococcus aureus, and is active against some strains. These are Acinetobacter spp., Providencia stuartii, Klebsiella spp., Alcaligenes spp. The medication does not affect anaerobic microorganisms. Stability of bacteria with respect to pipemidic acid develops rather slowly.
The drug "Palin" is widely used in urological and gynecological practice. Its active substance is pipemidic acid, which is characterized by bacteriostatic and bactericidal properties.
The mechanism of action of the drug is based on the ability of pipemidic acid to suppress the molecules of DNA-topoisomerase II bacteria, normalizing the transcription, repair and replication of bacterial DNA. When used in high doses, the drug gives a pronounced bactericidal effect, in a low dosage has a bacteriostatic effect.
After ingestion, the drug is absorbed by the gastrointestinal apparatus. The greatest concentration of active substance occurs after 1-2 hours, after the use of "Palina". This drug has a small degree of connection with blood proteins, about 30% or less. The medicine is not metabolized in the human body. It is excreted by the renal organ, by creating in the urine high concentrations of the active component. For a day leaves from 50 to 85% of a medicine, from the accepted dosage. A small part of pipemidic acid leaves through the intestine in an unchanged form.
Analog "Palina" "Urotraktin" acts in a similar manner on the body. He, as well as the first drug, contains in its composition pidipemic acid.
Palin: indications for use and contraindications
The drug "Palin" is prescribed for inflammatory processes in the urinary system and in the small pelvis. Pathologies can be both acute and chronic. Caused by microorganisms that are sensitive to this drug. These are diseases such as urethritis, pyelonephritis and prostatitis. Helps "Palin" from cystitis. The drug can be used in complex therapy in the treatment of certain gynecological diseases.
The drug "Palin" is used to prevent the recurrence of chronic diseases of the urinary system. It is also used for the prevention of infectious complications that can occur with instrumental examinations, as well as with various manipulations in the urological and gynecological area.
Analog "Palina" "Pimidel" has the same indications for the use of the medicinal product and, if necessary, can replace the first mediamment.
Contraindication to the use of the drug "Palin" is the individual intolerance of the active substance and minor components of the medicament. Do not take the drug with epilepsy and pathologies of the central nervous system, accompanied by cramps. Do not prescribe a medicine for kidney failure, when the clearance of creatinine is less than 10 ml / min. Prohibition of the use of medication is liver failure, especially hepatitis, in a chronic or active form, as well as cirrhosis.
Contraindication is porphyria, a disease transmitted by inheritance and accompanied by malfunctions of hemoglobin synthesis. Do not recommend medication to pregnant and lactating women, as well as children whose age has not reached fourteen years.
The drug is not prescribed to elderly people over 70 years of age and to persons with hypersensitivity to acetylsalicylic acid, quinolone drugs.
Palin medication: instructions for use
The price of this drug varies in the region of 200-250 rubles. Despite the fact that the medicine can be bought in a pharmacy without a doctor's prescription, it should not be taken by yourself, without the doctor's appointment.
The drug is used orally. Tablets and capsules are not chewed, but swallowed whole, washed down with a large amount of water (about 250 g). During therapy, you should drink from two liters of fluid per day and monitor the amount of urine released. Also, when treating the drug, one should not sunbathe, moreover, one should try to avoid direct UV radiation in every possible way. If the treatment with this medicine is prolonged for a long period, then periodically it is necessary to take a general blood test, monitor the liver function and kidneys by biochemical analysis of the plasma.
It should be used according to the prescription of the doctor medicine "Palin". Dosage for adults is 400 mg per day, divided into two doses in twelve hours. There are situations (staphylococcal infections), when "Palin" is prescribed in a higher dose of 200 mg three times a day. In this case, the interval between taking the medication is eight hours.
The duration of the therapeutic course is determined by the doctor individually for each patient. The average duration of treatment is ten days. If necessary, the medicine can be consumed up to 6-8 weeks.
Warns that people with severe disability of the renal system need to adjust the dose when using Palin medication, instructions for use (the price of the medication is available and lower than that of some analogues, for example, in Nevigramon).
Women with the intake of tablets or capsules may additionally be prescribed vaginal suppositories, which should be applied once a day, at night. They last for 7-10 days.
When using "Palina" in conjunction with antacids and sucralfate, absorption of pipemidic acid in the digestive tract may decrease. If you can not abandon their integrated use, you should maintain a gap between taking medication, equal to 2-3 hours.
Continuous use of "Palina" together with theophylline and caffeine helps to increase the concentration of the last components in the blood. "Palin" enhances the action of cimetidine, warfarin, rifampicin, as well as nonspecific anti-inflammatory drugs.
If the "Palin" is taken simultaneously with antibiotics-aminoglycosides, then a stronger bactericidal effect on microorganisms occurs.
With the joint use of Palina with other medicines related to quinolones, as well as in its complex application with non-narcotic analgesic agents, the likelihood of seizures increases.
In children, "Palin" can cause an increase in muscle tone. Still pipemidovaya acid has the feature of accumulating in the cartilaginous tissue.
For children older than fourteen years, the drug is used in the same dosage as for the adult population. Children under the age of fourteen years are not prescribed a drug.
Side effects, overdose
When treated with Palin, side effects may occur from time to time. From the side of the digestive apparatus, sometimes patients are concerned about nausea, vomiting reflex, diarrhea, gastralgia. In rare cases, there may be pseudomembranous colitis accompanied by a severe form of diarrhea.
During the application of "Palina" there are negative phenomena from the nervous system. This is a headache, disruption of the visual apparatus, excessive excitation, depressive state, confusion of thoughts, various hallucinations.
Patients may be bothered by tremors of the limbs, convulsions. In some cases, there is a violation of sleep.
During the therapeutic course, there is a violation of the hematopoiesis system. People with a deficiency of glucose-6-phosphate dehydrogenase may experience hemolytic anemia. When taking medication, there were cases with the development of eosinophilia. Older people are sometimes worried about thrombocytopenia.
During the use of tablets (capsules), allergic reactions were recorded, such as itchy skin, rashes on the skin, Stevens-Johnson syndrome.
Among other negative reactions people were concerned about photosensitivity, there was resistance, as well as superinfection.
If the drug is taken in doses exceeding those specified in the instructions, an overdose of the drug may occur. Her symptoms are nausea, headache, vomiting, dizziness, tremors and cramps of limbs, confusion of thoughts.
If more than four hours have passed after using the drug, then you should rinse the stomach and drink activated charcoal. If negative reactions appear in the central nervous system, then symptomatic therapy is prescribed. To withdraw the medicine from the body helps boost diuresis.
The medicine "Palin" should be prescribed with care to patients suffering from cerebrovascular accidents in amnesia. This applies to hemorrhages in the brain, as well as spasms of the cerebral vessels. Also with caution, people should use "Palin", whose age has passed the border of 70 years.
Passing the therapeutic course, patients should drink plenty of clean water, from two liters per day. Constantly you need to monitor diuresis. Because of the danger of developing photosensitization with the use of the drug, you must avoid ultraviolet radiation.
People who are allergic to quinolones should use caution when applying Palina, since there is a possibility of cross-sensitivity.
With prolonged treatment, you need to monitor the overall blood count. Watch for the work of the hepatic organ and kidneys. From time to time, check the susceptibility of microflora to the active substance of the drug.
With the use of "Palina" there is a possibility of a false positive urine for glucose when using the Benedict reagent or Felling's composition. As a result, it is advised to use enzymatic reactions with glucose oxidase.
When taking the drug, you need to refrain from dangerous activities associated with increased concentration of attention and requiring quick reaction.
Many people are interested in: "Palin" - an antibiotic or not? This drug is an antibiotic, so when you use it, you should not drink alcohol to avoid negative reactions of the body.
Above was told about the action of the drug Palin. How to take it, in more detail tells the instructions for use. Now a little about the analogues of the medicine, which are used when the treatment "Palin" was ineffective or caused negative reactions of the body. The most common substitutes, similar in composition, are:
- "Vero Pipemidin."
- "The Pimidel."
"Palin" is often replaced with drugs that have a different composition, but they work in a similar way. The most popular of them are:
- The Monural.
- "Tsiprolet A".
These and other analogs can replace the Palin if necessary, but they must be selected only by a doctor.
One of the most accessible analogues of Palina is "Ofloxacin". The price for it fluctuates around 70 rubles for 10 tablets. Produce the drug in Russia. The active ingredient is ofloxacin, in one tablet it contains about 400 mg.
The drug has a wide range of applications and is indicated for various infectious diseases. These are diseases of the respiratory tract, ENT organs, urinary system, kidneys, small pelvis, genitals, etc. It has a bactericidal and antibacterial effect.
What is better to take is "Palin" or "Ofloxacin", - only the doctor will tell. Both drugs are antibiotics, but the second has a wider range of uses. In connection with this, doctors are appointed more often "Ofloxacin". The price for it is an added advantage.
"Kanefron" as a substitute for "Palina"
"Kanefron", as "Palin", can be used to treat diseases of the genitourinary system. But its difference from "Palina" in its naturalness. The composition of the medicine includes a herb of centipedes, rhizome rhizome and leaves of rosemary. The natural content of the drug helps to avoid many side effects, but the course of treatment is longer. It is worth this drug from 350 to 400 rubles for 60 tablets. Produced in Germany.
Adults drug prescribed 2 tablets 3 times a day, that is, 6 tablets a day. "Kanefron" is recommended to take from 2 to 4 weeks. Packaging is only enough for 10 days of treatment. Therapy costs them more than treatment with Palin.
"Palin" and "Kanefron" have the same indications for use and can be used together in the treatment of cystitis. The first is an antibiotic, and the second is completely natural. Their complex reception is very effective, since drugs enhance each other's action. Many doctors use this combination in their urological practice.
"Nolitsin" - another drug that can replace the "Palin" if necessary. Produced in Slovenia. The price of 10 tablets is about 130 rubles. The active substance is norfloxacin. In one tablet it contains about 400 mg.
The drug "Nolitsin" has a wider range of applications than Palin. The patients' comments say that it is more effective than the last mentioned drug. During treatment, side effects are possible. Therapeutic course lasts from 7 to 10 days. Together with him, it is recommended to drink a probiotic.
What to choose for treatment - Palin or Nolitsin? This should be decided by the doctor, relying on the patient's condition and the severity of the illness. Do not engage in self-medication and choose a drug to treat urinary diseases yourself. So you can not only start the disease, but also get serious side effects.