Strychnine - what is this? Instructions for use, symptoms of poisoning

As is known, many drugs are toxic to the body. It all depends on what dosage to use this or that drug. There are also substances that are poisons. Their use is very dangerous. Nevertheless, some of them are used in medicine. For example, drugs created on the basis of bee and snake venom, strychnine. The dose of such medicines must be strictly observed. After all, if you exceed the amount of active substance, you can cause not only severe poisoning, but also a lethal outcome. An example is the strychnine drug. The poison contained in this substance is very toxic to the human body and animals. But when used in small amounts, it has a curative effect.

Strychnine - what is it?

This substance is of vegetable origin. It is used not only for medical purposes, but also as a poison for rodents. Given the high toxicity, people who are prescribed drugs based on this substance, ask: strychnine - what is it? It is known that this tool was allocated as far back as 1818. Get it in the lab. Where is the strychnine contained and what chemicals do they belong to? This agent is a natural indole alkaloid. It is contained in the seeds of the plant of chilibiha. They are also called "vomit". Chilibuha grows in the tropical climate of Africa and Asia. In addition to strychnine, the seeds contain other alkaloids. For example, the substance brucine. For medical purposes in laboratory conditions, strychnine nitrate is prepared, in other words - nitric acid salt. In large doses, the alkaloids contained in the seeds of chiliobook are considered poisons. They have a high degree of toxicity and are deadly to humans.

The effect of strychnine on the body

Strychnine substance - what is it? Some data on the impact of this tool can be found in literary works. Among them - the novels of famous classics of Jack London, Agatha Christie. In these works, heroes die due to the effect of this poison. In addition, the English writer Herbert Wells describes in one of his stories a biological stimulant, thanks to which a person feels a surge of energy. It's about strychnine. In fact, this substance has a similar property. This action strychnine due to the fact that it can block some neurotransmitters. Among them, glycine is a substance that inhibits impulses in the spinal cord. Due to this effect, strychnine is considered to be a stimulant for the nervous system.

With the use of small doses of the substance in the body, the following processes occur:

1. Stimulation of the senses. Thanks to this, functions such as sense of smell, hearing, touch, taste and vision are enhanced.
2. Excitation of skeletal muscles and myocardium.
3. Strengthening metabolic processes in the body.
4. Excitation of the nervous system, including the respiratory and vasomotor center.

Application of strychnine in pharmacology

Taking into account the effect of strychnine on the nervous system, it is also used in medicine. Nevertheless, the medicines that contain this poison are used only in cases of emergency. Medicinal preparations have in their composition nitrate strychnine. It practically does not dissolve in cold water and ether. Nitrate is a white powder, consisting of crystals. Medications containing this substance are classified as first class drugs, that is, they are especially dangerous drugs. Given its effects, strychnine is used for diseases accompanied by inhibition of nerve impulses. The main branch of medicine in which these drugs are used is neurology. In addition to pharmacology, strychnine is used as a poison for fighting rodents - mice and rats. Previously, the substance was used only for deratization.

What preparations contain strychnine

So, "strychnine" - what is it and in what medicines is it contained? Preparations that have this poison in their composition belong to the group of stimulants of the central nervous system. In pharmacological practice, there are 2 medicines containing strychnine. These include:

1. Tincture of chilibigh. It is a brown liquid with a bitter taste. It is necessary to strictly observe the following ratio: 16 grams of dry matter (extract of chiliboux) per 1 liter of 70% alcohol solution. This drug contains not only strychnine. The composition of the drug is represented by other alkaloids, including brucine. The tincture contains 0.25% of the active ingredient.
2. Dry extract of the plant of chilibiha. It is also called the drug of the vomit. It is a brown powder. It has no smell. For consumption, the powder is dissolved in water. At the same time, the ratio 1/10 is observed. The powder contains about 16% of the alkaloids of chilibukha - strychnine and brucine.

These medicines do not have commercial names. Used in the form of a solution and tablets.

Preparations containing strychnine: instructions for use

Considering that strychnine is a particularly dangerous poison, it is very important to follow the instructions for use. In no case should you exceed the therapeutic dose of the medication! Also, attention should be paid to the contraindications to the use of preparations containing strychnine. Such medicines can not be consumed by children under 2 years of age, pregnant and lactating women. Prescribe the drug can only be the attending physician. So, medicines containing strychnine: instructions for use.

1. Oral administration of the drug. In most cases, drugs are consumed inside. To do this, use alcoholic infusion of chilibuks and tablets (contain a dry extract). Depending on the severity of the symptoms, age and weight of the patient. Adults recommend a dose of 0.5 to 1 mg 2-3 times a day. If the drug form of the drug is an alcohol tincture, then 3-10 drops are prescribed (in 1 dose). The maximum dose for adults is 5 mg per day. Children the amount of active substance is selected individually, depending on the body weight. A single dose is from 0.1 to 0.5 mg.
2. Subcutaneous administration of medicament. A 0.1% solution of strychnine is used. The daily dose is 1 ml (1 ampoule) of the drug.

Indications for strychnine application

Despite the effectiveness of drugs that have strychnine in their composition, they are prescribed in rare cases. Most doctors recommend patients less dangerous drugs. Nevertheless, there are cases when the use of strychnine is necessary. There are the following indications for the use of such medications:

1. Heavy neurological disorders. Among them - paralysis and paresis of limbs after a stroke.
2. Lack of appetite. Given that strychnine nitrate has a pronounced bitter taste, it stimulates the desire to eat.
3. Violation of acuity of hearing and vision. In this case, drugs are prescribed only in those cases when there are functional changes in the work of the sensory organs.
4. Impotence. Currently, drugs containing strychnine, are practically not used for erectile dysfunction.
5. Chronic alcoholism, not amenable to treatment by other means.

Contraindications to strychnine application

Preparations containing strychnine are contraindicated for people suffering from cardiovascular diseases (angina pectoris, arterial hypertension, atherosclerosis) and respiratory system (bronchial asthma, COPD). Also, they can not be used in pathologies of the thyroid gland, liver and kidney failure. It is strictly forbidden to prescribe such medications during pregnancy, lactation, children under 2 years of age, and people who have a history of convulsive syndrome.

Symptoms of strychnine poisoning

Strychnine poisoning is considered an extremely dangerous condition. Symptoms are similar to the clinical picture of tetanus. There are following signs of poisoning: photophobia, respiratory depression, convulsions, spasm of masticatory muscles, impaired swallowing. A lethal dose of strychnine is 1 mg per kg of body weight.