The drug "Itraconazole" (tablets, ointment, cream, solution or capsules) is used to treat various fungal infections. At the same time, it is equally effective for the treatment of diseases localized in different parts of the body.
The drug itself and any analogue of "Itraconazole" belongs to the class of antifungal triazoles. This artificially synthesized drug prevents the synthesis of ergosterol, necessary for the normal life of fungi. The drug "Itraconazole" suppresses the development of dermagophytes, yeast fungi Candida, mold fungi and other pathogens. Some strains of microorganisms are resistant to the action of this agent.
The drug "Itraconazole" is available in tablets, capsules, as a solution (liquid), ointment. On sale there is far more than one analogue of "Itraconazole". Similar preparations are issued in different dosage forms.
Any analog of "Itraconazole" and, in fact, this drug itself is most often used to treat fungal infections of the respiratory system, in particular, the lungs. These medications are also used to treat patients who have fungus affected by the throat, oral cavity or esophagus. Very often this infection affects the nails of a person. In this case, use another drug form of the drug "Itraconazole" - an ointment for external use, which effectively fights against a fungal infection on the nails or skin. It is prescribed for psoriasis.
Indications for use
This drug and its analogs are used for the following diseases:
• colorful lichen;
• systemic aspergillosis and candidiasis;
• tropical mycosis.
The duration of therapy can be adjusted depending on the clinical picture. Most often this drug is taken 1 time per day. The most commonly used treatment regimens are:
• Pityriasis: within a week for 200 mg;
• dermatomycosis: during the week, 200 mg or 100 mg for 15 days;
• onychomycosis: 3 months of 200 mg or a week of 200 mg / 2 times a day;
• Hand and foot dermatophytosis: a week of 200 mg or 100 mg for 1 month;
• Candidiasis: within 15 days of 100 mg;
• keratomycosis: within 3 weeks of 200 mg.
Methods of reception for pulmonary infections
For the treatment of fungal infections of the respiratory tract, tablets or capsules of "Itraconazole" are prescribed. Analogues are cheaper, but they can have a more distant in time action, so the disease is more difficult to win in the shortest possible time. Tablets or capsules are taken 1-2 times a day, during or immediately after a meal. Usually, at least 3 months are required to treat fungal infection of the lungs. In some cases, the doctor may prescribe the following course of therapy: 3 tablets a day for 3 days, and then 3 months for 1-2 tablets per day.
Taking the drug for nail infection
The drug "Itraconazole" - a pill that is prescribed for the treatment of fungal nail infections. For complete cure it is taken 1 time per day for 12 weeks. More effective is the oral solution of "Itraconazole". It is taken for 1-4 weeks 1-2 times a day. In this case, for a faster absorption, the drug is consumed on an empty stomach. Choose the most optimal scheme of taking the drug or designate an analog of "Itraconazole" is only able to the attending physician, who will take into account the severity of the disease and the general condition of the patient. In especially neglected cases, another form of the drug "Itraconazole" is used to treat fungal nail infection - ointment, which is applied to the affected areas 1-2 times a day.
Other uses of the drug
Any analog of "Itraconazole" and the drug itself in recent years are increasingly being used in the complex therapy of various types of fungal infections in patients affected by HIV and AIDS. In this case, self-treatment is unacceptable, since only the attending physician can correctly assess the patient's health and possible risks of taking Itraconazole.
The drug "Itraconazole", analogues of this medicine should be taken in accordance with the instructions and recommendations of the treating doctor. In smaller or larger doses, they can be ineffective or can harm a patient's health.
Capsules "Itraconazole", analogous to cheap or expensive are taken as follows: capsules and tablets are swallowed whole. Do not chew or crush them. If the level of acidity in the stomach decreases due, for example, to cystic fibrosis, this should be reported to the treating physician.
In some cases, the regimen for taking this medication can be changed. Most often, this occurs when the patient takes the following drugs during therapy: Famotidine, Nizatidine, Esomeprazole, Cimetidine, Omeprazole, Ranitidine, Lansoprazole, Pantoprazole, Rabeprazole. "
In some cases, itraconazole is contraindicated in patients. Instruction of similar drugs often prohibits the intake of such antifungal medicines when allergic to their components. That is why when prescribing therapy using these drugs, the attending physician must know exactly whether the patient has an allergic reaction to the substances that make up their composition.
Medication can not be taken by pregnant and lactating women. To prevent possible pregnancy during treatment, it is necessary to use effective contraception. With caution appoint this drug to elderly patients. Admission to it in childhood is possible only if the benefit exceeds the potential risk. It is not recommended to take the drug for patients with heart failure, ischemia, severe lung diseases, renal insufficiency.
"Itraconazole", analogues of the drug should not be taken in a double dose with a possible missed medication. It is best to forget about the missed dose and then follow the admission scheme. Do not overdose this product or its analogues, as this can lead to very serious health complications.
Interaction with other drugs
Before receiving "Itraconazole", the attending physician should be aware of what preparations the patient took before this. This particularly applies to the use of medications such as Efavirenz, Everolimus, Sildenafil, Aliskiren, Rifabutin, Apixaban, Nevirapine, Dasatinib, Ibrutinib, Salmeterol, Darifenacin, Nilotinib, Carbazepine, Sunitinib, Colchicine, Rivaroxaban, Phenobarbital, Tamsulosin, Isoniazid, Phenytoin, Vardenafil, Rifampicin, Nevirapine , "Temsirolimus".
In addition to the above drugs, before applying "Itraconazole" should inform the doctor about the following means:
• HIV protease inhibitors;
• food additives (dietary supplements).
With the simultaneous use of "Itraconazole" and antacid preparations, the latter are used 1 hour before or after a couple of hours after taking the antifungal medication.
The drug "Itraconazole" sometimes causes dizziness and visual impairment in the form of a bifurcation of the image. When taking this medicine, you can not drive a car and work with different techniques. The most frequently observed side effects when taking it include bloating, increased gas production, diarrhea, constipation, heartburn, the appearance of an unpleasant aftertaste in the mouth; Increased sweating, dizziness, headache, bleeding and soreness of the gums, muscle pain, decreased muscle tone, runny nose, fever, joint pain, depression, decreased libido, hair loss.
The following side effects are considered to be especially dangerous for a patient's health: double vision, nausea, vomiting, abdominal resuscitation, heart failure, hepatitis, involuntary urination, anaphylactic and allergic reactions, darkening of the urine, ringing in the ears, hearing loss, loss of appetite, excessive fatigue , Yellowing of the skin and eyes, numbness and tingling of soft tissues and skin, photophobia, skin rash, itching, hoarseness, pulmonary edema, menstrual irregularity, swelling in the face, throat, hands, ankles. If any of the above symptoms occur, it should be reported immediately to your doctor.
How to choose an analogue of "Itraconazole"
Every year an increasing number of people face the problem of fungal diseases. At the same time, many patients decide that it is not necessary to purchase "Itraconazole" for their treatment. Analogues are cheaper, so they are often given preference. In fact, the question of choosing this drug or its analogs should be decided only by the attending physician. In some particularly severe cases of complete recovery, the patient is helped to achieve exclusively "Itraconazole". Analogues are cheap, but not all of them are as effective as the given drug.
What can replace Itraconazole? Ointment, analogs of this drug in other dosage forms are widely represented in pharmacies. Structural analogues include the following medicines produced in the capsule feed: Irunin, Intramycol, Itrazol, Miconihol, Canditral, Kanazol, Tecnazol, Orungal, Rumikoz, Orungamin "," Orunite ".
Analogues of "Itraconazole" on the therapeutic effect are the following drugs:
- Capsules: Diflucan, Diflazon, Itrazol, Orungal, Rumikoz, Flukostat, Flukonazol, Fungolon;
- Tablets: Atifin, Binafin, Ketoconazole, Fungoterbine, Exifin, Nizoral;
- Ointments, creams, gels: Akriderm, Lamizil Dermagel, Terbizil, Ekzifin, Mycomomax, Mycosoril, Triderm, Fungoterbine, Ketoconazole, Kanison, Lamitel , "Candide", "Amiklon", "Zalain", "Canison", "Atifin", "Clotrimazol", "Lamizil", "Ifenek", "Lamitel", "Terbiks", "Imidil";
- Candles, vaginal tablets: Zalain, Candide, Canison, Mikogal, Imidil.
What is the opinion of people who took the drug "Itraconazole"? Analogues, reviews of which often have a negative color, and even this drug itself often does not bring the expected results from therapy. At the same time, the presence of a huge number of contraindications and side effects makes these medicines quite dangerous for the health of many patients. And the risk of unpleasant consequences from the use of "Itraconazole" and its analogues increases significantly if the instructions of the attending physician or self-treatment are not observed.
Very often there are negative reviews about the drug "Itraconazole" (candles). Analogues of this drug are also often perceived by patients with caution. This is due to the fact that in some cases the therapy of fungal diseases with candles should be supplemented with the intake of "Itraconazole" or its analogs inside.