Zodak (drop) instruction

Zodak belongs to the second generation antiallergic agents with prolonged exposure. The active substance of the preparation is cetirizine dihydrochloride.

When using therapeutic dosages of "Zodak" (drops), the instruction indicates that there is no sedative effect, including drowsiness. The active component is able to influence the early (initial) phase of allergic reactions - histamine-dependent, and to the late cell stage. Under the influence of cetirizine, release from mast cells and basophils of histamine is suppressed, migration of eosinophils and other cells decreases.

The maximum concentration of the active ingredient in the plasma is noted in half an hour - an hour after taking the medication. The drug is not subject to active metabolic changes during primary passage through the liver. Approximately two-thirds of cetritisine leaves the urine from the body in unchanged form.

The drug is prescribed for the treatment of urticaria (including accompanied by fever) and itching of a different nature. The medication is used in the symptomatic therapy of allergic conjunctivitis, as well as all-the-year-round and seasonal allergic rhinitis.

Zodak. Instructions

Drops are prescribed twenty drops once a day to patients from the age of twelve.

From 6 to 12 years, appoint 10 drops twice a day (20 drops are allowed once a day), from 2 to 6 years, five drops are recommended twice a day (maybe ten drops once a day). Zodak children under two years, including newborns, should take five drops twice a day.

Side effects occur rarely, as clinical practice shows. As reactions to the drug, patients may experience difficulty urinating, dry mouth, drowsiness, headache, fatigue, dizziness. In some cases, an increased content of bilirubin and an increase in the activity of liver enzymes can be detected.

Zodak (drops). Instruction: description

The drug is available in 20 ml vials. Solution with a slightly yellowish tint or transparent.

Auxiliary components: methylparaben, sodium acetate, propylparaben, sodium saccharin, glycerol 85%, purified water, propylene glycol, acetic acid.

The instruction "Zodak" (drops) is not recommended during lactation and pregnancy (in all trimesters). If necessary, take a medication breastfeeding breastfeeding woman temporarily suspended.

The pharmacokinetic indices of the interaction of the active ingredient (cetirizine) with pseudoephedrine, cimetidine, erythromycin, azithromycin, ketoconazole have not been studied.

In disorders of renal function of moderate or severe degree when using Zodak (droplets), the instruction indicates the need to establish individual intervals. It depends on the severity of the condition. Thus, with minor changes in the interval and dosage adjustment is not required.

In disorders of renal function of mild degree (30-49 ml / min creatinine clearance), the reception of a zodiac in the usual regime of 5 mg per day is recommended, with a severe degree (creatinine clearance ≥ 30 ml / min) should be taken 10 mg once a day, Every two days. If there are contraindications to hemodialysis in the terminal stage (creatinine clearance ≥ 10 ml / min), the medication is contraindicated. Dosage for children with renal function deficiency should be calculated individually, taking into account the body weight and the creatinine clearance rate.

The use of the drug for the treatment of patients with disorders of the hepatic function of correcting (decreasing) the amount of medication taken does not require.