"Fliksotid": instructions for use, testimonials. Drug analogues

Do you know what the "Fliksotid" preparation is for? Instructions for the use of this medication, its indications, composition, side effects and form of release will be described in detail below. In addition, we will tell you whether this medication is contraindicated, what will happen in case of an overdose, what pharmacological properties it has, and so on.

Composition and form of the drug

In what form is it possible to purchase the preparation "Fliksotid", the instruction on which application is necessarily attached to the product? Currently, this medication is sold only in the form of inhalation aerosol. The main active substance is fluticasone propionate microionized. The preparation also includes an additional component, such as tetrafluoroethane.

A medicament is produced in a metal inhaler that has a concave bottom and a dispensing device equipped with a sprayer. Inside the container there is a suspension of white or almost white color. When buying this product, you should always pay attention to the surface of the inhaler. Its valve should not have visible defects.

Types of aerosol medicinal product

Depending on the extent to which the active ingredient is present in the suspension, three types of medication are distinguished. Their names are as follows: "Fliksotid Diskus", "Fliksotid Nebula" and "Fliksotid Evohaler".

Pharmacological characteristics of the drug

What is the preparation "Fliksotid"? The instruction for use states that its active element belongs to the group of local effects. With inhalation administration, the active substance produces pronounced anti-allergic and anti-inflammatory effects. As a result, the severity of symptoms is markedly reduced, as is the frequency of exacerbations of pathologies that are accompanied by airway obstruction (eg, chronic bronchitis, bronchial asthma and emphysema).

Principle of action of a medicament (aerosol)

How does the preparation "Fliksotid Nebula" and other types of this drug work? The basic substance inhibits the proliferation of mast cells, macrophages, eosinophils, neutrophils and lymphocytes, and also reduces production and releases inflammatory mediators and other biologically active substances (such as histamine, prostaglandin, leukotriene, cytokine).

In chronic obstructive pulmonary disease, there is a high effectiveness of this drug on the respiratory system, so that the symptoms become less pronounced, the frequency and severity of exacerbations decrease, and the need for additional GCS tablets is lost. As a result, the patient's quality of life improves.

The systemic effect of this drug is minimal. In this regard, in therapeutic doses, it has virtually no effect on the hypothalamic-pituitary-adrenal system.

The "Fliksotid" medication, analogues of which will be named below, quickly restores the patient's response to bronchodilators, reducing the frequency of their use.

The therapeutic effect after the application of an aerosol inhaler starts within 24 hours and reaches a maximum for two weeks or more. The result is stored for several days after the drug is withdrawn.

Pharmacokinetics of aerosol

After the aerosol "Fliksotid" was used for its intended purpose, the absolute bioavailability of its active substance is 8-11%.

Systemic absorption of the drug occurs predominantly in the lungs. By the way, initially absorption is carried out quickly, and then slows down. During the procedure, a portion of the inhaled suspension may be swallowed by the patient. However, its systemic effect is minimized due to the poor solubility of the drug in the water, as well as intensive metabolism when passing through the liver.

The binding with plasma proteins in this drug is moderately high and is about 91%. The active element of the drug is metabolized in the liver with the participation of CYP3A4. As a result, inactive metabolites are formed.

The drug "Fliksotid", reviews about which are mostly positive, has a fairly high plasma clearance. The half-life period is approximately 8 hours. It is excreted in the form of metabolites along with urine.

Indications for the use of an aerosol

In what cases do you use the drug "Fliksotid"? Instruction for use informs that the medicine is prescribed for the treatment of patients who suffer from bronchial asthma, taking place in severe or moderate form. Also, the medication is used to prevent seizures when taking systemic glucocorticosteroids.

In addition, the medication is indicated for patients with chronic lung diseases. Use it to reduce bronchial obstruction, as well as improve the ventilation work of respiratory organs.

Contraindications to the use of aerosol

At what conditions in any case it is impossible to use the inhaler "Fliksotid"? Contraindications are the following:

• Hypersensitivity of the patient to any component of the drug;
• Acute bronchospasm;
• The status is asthmatic (as a first remedy);
• Age up to 1 year.

It should also be noted that this medication is undesirable to use for relief of attacks of bronchial asthma.

Careful use of the drug

In what situations is extremely carefully prescribed the preparation "Fliksotid"? The doctors say that this remedy should be used strictly under the supervision of specialists in glaucoma, liver cirrhosis, pulmonary tuberculosis, hypothyroidism, pregnancy, systemic infections (bacterial, fungal, parasitic or viral), and during lactation and osteoporosis.

The preparation "Fliksotid" for inhalations: the instruction

Depending on the type of preparation, its methods of use and dosage can vary significantly. For example, to achieve the desired effect, the aerosol "Flixotide Diskus" should be used regularly, even during remission.

The duration of therapy and the optimal dose of medication should be determined only by the doctor, taking into account the patient's condition and the overall clinical picture. For adults, the dosage is 100-1000 μg 2 times a day. The use of medication begins with minimal volumes that produce a therapeutic effect. If necessary, the amount of medication used can be increased. The maximum dose of the drug should not exceed 2000 mcg.

The "Fliksotid" medication for children from 4 years old who suffer from bronchial asthma is prescribed in the amount of 50-100 μg twice a day. If necessary, this dosage is gradually increased to 400 μg per day. As for adults with chronic lung diseases, they are usually given 500 μg of drug twice a day.

How to use the drug "Fliksotid Evohaler"?

This tool should be used regularly. Before use, the medication should be sprayed several times to obtain a uniform dose. Also the vial of the suspension must be shaken vigorously. When spraying the aerosol, the patient needs to take a slow breath. The mouthpiece should be cleaned at least once a week.

How to use the recommended "Fliksotid" medication? Doses of this drug are calculated as follows: a single volume of the drug corresponds to two sprays.

With bronchial asthma, adults are prescribed 100-1000 μg of active substance twice a day. Use of the drug should start with small effective doses, after, if necessary, they can be increased. The maximum volume of the drug should be 2000 μg.

How to treat babies using the aerosol "Fliksotid"? Inhalations for children over the age of four with a disease such as bronchial asthma are prescribed in an amount of 50-100 μg twice a day. If necessary, the dosage can be gradually increased. The maximum amount of the drug consumed for children over the age of four is 400 micrograms.

For adults with chronic obstructive pulmonary disease, the medication is prescribed 500 μg twice a day. If no improvement is observed after 3-6 months after the start of therapy, the treatment regimen should be changed.

If a child aged 1 to 4 years is diagnosed with bronchial asthma, he is prescribed 100 μg of the drug twice a day. In this case, inhalation is recommended to be carried out with the help of a pediatric spicer with an interesting name "Bebihaler".

Aerosol Fliksotid Nebula: instructions for use

This medication can be used for oral (with the use of a mouthpiece) or nasal (with a face mask) inhalations. Also, the drug is often prescribed as an aerosol for an inkjet nebulizer. It is extremely undesirable to use ultrasound devices.

If prolonged administration of the agent or administration of small doses is necessary, then prior to inhalation procedures, the drug is recommended to dilute in a solution of sodium chloride.

Adults and adolescents over 16 years of age are prescribed 0.5-2 mg twice daily. The maximum dosage should be adhered to within a week after the attack of bronchial asthma, and then it is gradually reduced.

If the effect is positive and the condition improves, we can switch from the drug "Fliksotid Nebula", the instruction of which always goes in the kit, to other types of this drug.

To a child from 4 to 16 years of age, the drug is prescribed in an amount of 1 mg twice daily.

Cases of overdose

In case of an overdose, the patient may experience a temporary depression of the hypothalamic-pituitary-adrenal system, a significant suppression of the adrenal cortex, an acute adrenal crisis in children who received a dose of 1000 mcg per day or more.

Among other things, patients are depressed, convulsions and hypoglycemia occur. It should also be noted that the acute adrenal crisis usually develops against the background of such conditions as severe injuries, surgery, the presence of infection and a sharp decrease in the dosage of the drug.

Adverse events

Can the reception of the preparation "Fliksotid" negatively affect the patient's health? Side effects are available in almost all medical devices. And the presented inhaled medicine is no exception.

• Immune system: skin reactions due to hypersensitivity, angioedema (oropharynx and face), irregularities in the respiratory system (bronchospasm or dyspnea), anaphylactic shock.
• Parasitic and infectious diseases: Candidiasis of the pharynx and mouth, and candidal stomatitis. With such deviations, it is recommended to rinse the throat and mouth with ordinary water. Antifungal agents of local action may also be used. Very frequent side effect after the use of aerosol is pneumonia, but only in patients with COPD.
• Metabolism: hyperglycemia.
• Endocrine system: Cushing's syndrome, oppression of the adrenal cortex, lowering of bone mineralization, growth retardation, cataract, glaucoma.
• Nervous system: anxiety, behavior and sleep disorders, irritability and hyperactivity (especially in children).
• Subcutaneous fat: the bruising.
• Respiratory system: hoarseness of the voice (it is recommended to rinse the throat and mouth with water immediately after the procedures), paradoxical bronchospasm.

Special instructions when using a medicament

Drug abolition is highly discouraged.

Special care should be taken when treating inhaled GCS patients with an inactive or active form of pulmonary tuberculosis.

After prescribing the medicine, the doctor must check whether the patient can use the inhaler. During the procedure, he needs to make sure that bringing the drug into action passes synchronously with the inhalation. Only in this way will the patient be able to provide optimal delivery of the active element to the lungs.

It is recommended to constantly monitor the growth dynamics of young children who receive inhaled GCS for a long time.

When transferring a patient from taking systemic GCS to an inhalation treatment, allergic diseases (for example, eczema or allergic rhinitis), which were previously suppressed by systemic medicines, can become aggravated. In such cases it is recommended to carry out symptomatic therapy with antihistamines or topical preparations.

As with most inhalation medicines in aerosol packs, the therapeutic effect may decrease with the cooling of the can.

To date, there are rare reports that the patient using the drug we are considering increases blood glucose levels. This should be remembered by doctors when prescribing the drug to patients with diabetes mellitus.

The influence of the active substance on a person's ability to control the machine and work with mechanisms that require increased concentration of attention is unlikely.

Drug analogues

What medicament to buy if the patient could not buy the preparation "Fliksotid"? Analogs of this tool have almost the same properties. But before using them, it is recommended that you read the enclosed instructions and consult with a specialist.

At present, there are the following analogs of the presented medication: preparations "Kutiveyt", "Nazarel", "Fliksonase", "Fluticasone" and "Fluticasone propionate". It should be noted that the price of these medicines may differ, in comparison with the original. By the way, you can buy "Fliksotid" aerosol for 570 (50 mg, 120 doses), 840 (125 mkg, 60 doses) or 140 (250 mg, 60 doses) of Russian rubles.

Reviews about the inhalation preparation

What do doctors and patients say about the preparation "Fliksotid"? Reviews about this tool are mostly positive. This is due primarily to the fact that aerosol medication has a fairly high efficiency. It significantly reduces the incidence of attacks in patients with asthma, and also improves bronchial patency in those who suffer from chronic lung diseases.

As for negative reviews, they usually come from patients who used the medicine incorrectly or not for the doctor's prescription. Therefore, to achieve the most positive result before using the drug, as well as its analogs, it is recommended to study in detail the attached instructions for use. Moreover, it is necessary to visit a doctor who, in fact, should recommend this remedy, based on the results of a medical examination.

How to store an aerosol product?

Inhalation aerosol is recommended to be placed in a dark place, where the air temperature does not exceed 25 degrees. Shelf life of the drug is exactly two years. After this period, it is prohibited to use it.