Instructions for use "Ursocho". Analogs of the drug and reviews about it

This article will provide detailed instructions for the application of Ursohol. We will tell you about what this drug is prescribed for, what side effects and contraindications it has. In addition, from this article you will learn about the cost of the medicine in question, its analogs and pharmacological properties.

Composition of the medicine, form of manufacture and packaging

Instructions for the use of "Ursohola" says that this drug goes on sale only in the form of capsules. Ursodeoxycholic acid acts as an active element of this agent . As for the additional components, the following substances are used as pharmacists: potato starch, magnesium stearate, methylcellulose and anhydrous silicon colloidal dioxide.

In the pharmacy, the drug "Ursohol" can be purchased in contour squares, placed in a cardboard box (10, 50 or 100 pieces each).

Pharmacological properties of the drug

Instructions for the use of "Ursohola" contains information that this drug has hepatoprotective, membrane-stabilizing, immunomodulating, cholelithic and choleretic action.

The active element is easily integrated into the hepatocyte membrane, stabilizing its structure and protecting liver cells from damaging factors.

The drug inhibits the absorption of bile lipophilic acids in the intestine, increasing their "fractional" turnover during enterohepatic circulation. In this case, it induces the formation of bile, rich in bicarbonates. As a result, it increases its passage, and stimulates the withdrawal of bile toxic acids through the intestine.

By replacing the bile non-polar acids, the drug "Ursohol" is able to form mixed non-toxic micelles. Also, this drug reduces the synthesis of cholesterol in an organ such as the liver.

The active substance is capable of forming crystals (liquid) with cholesterol molecules , as well as preventing its absorption in the intestine, reducing the lithogenicity of bile, lowering the cholatecholesterol index, dissolving cholesterol stones and preventing their appearance.

With cholestasis, the drug activates calcium-dependent proteinase, lowers the concentration of bile acids (lithocholic, cholic, deoxycholic, etc.) and stimulates exocytosis.

Immunological activity of the drug is due to a decrease in the "attack" of immunocompetent immunoglobulins.

Pharmacokinetics of the drug

What does the instruction about the pharmacokinetics of the drug say? "Ursohol" is a medicine that is quickly absorbed into the small and ileum after ingestion. Good absorption in the intestines is due to passive diffusion and active transport, respectively.

The maximum concentration of the drug in the plasma is observed in 30-60 minutes after administration.

With constant use, the active substance becomes the main bile acid in the blood. At the same time, it is about 97-99% of the total content.

The drug penetrates well through the placental barrier. Approximately 50-75% of the dose of the drug is excreted together with bile, as well as with feces (partially).

Indications for use of the medicinal product

In what cases do doctors prescribe medication "Ursohol" to patients? The instruction, the responses of specialists say that this remedy shows itself perfectly with respect to such deviations as:

  • Toxic (including alcoholic and medicamentous) liver damage;
  • Acute hepatitis, active chronic hepatitis with cholestatic syndrome;
  • Biliary cirrhosis of the liver (primary), atresia of the intrahepatic biliary tract, sclerosing cholangitis (primary), cholestasis with parenteral nutrition;
  • biliary dyskinesia;
  • Cystic fibrosis of the liver (cystic fibrosis);
  • Reflux-gastritis (biliary) and reflux-esophagitis;
  • Presence of gallstones (cholesterol) in the gallbladder (if there is no possibility of their removal by endoscopic or surgical way).

Among other things, the drug we are considering is used to prevent liver damage during the use of hormonal cytotoxic drugs and contraceptives.

Contraindications to the use of the medicinal product

In what cases is it not recommended to use the medication we are considering? Feedback on the application "Ursohola" says that this drug has a fairly large number of contraindications. Let's consider their list right now:

  • Cirrhosis of the liver, especially in the stage of decompensation;
  • Increased sensitivity of the patient to drug substances;
  • Acute diseases of the gallbladder, intestines and bile ducts, which are inflammatory;
  • Ulcerative colitis nonspecific;
  • The presence of calcified gallstones, violation of the contractile work of the gallbladder, complete obstruction of the biliary tract, colic hepatic;
  • Severe impairment of the pancreas or kidney;
  • Crohn's disease;
  • pregnancy.

Is it possible to take "Ursohol" while breastfeeding? The doctors say that if it is necessary to prescribe a medication during lactation, it is necessary to resolve the issue of stopping breastfeeding. Otherwise, the health of a newborn baby can significantly deteriorate.

Drug "Ursohol": instructions for use

Comments on this drug, we will submit a little further. Now I want to tell you about how this drug should be properly taken.

Use the medicine we are considering should only be taken orally. In this case, capsules should never be chewed. They need only to drink a sufficient amount of clean water.

The daily dosage of this drug is taken at a time. Do this preferably immediately before bed.

For the treatment of chronic and acute liver diseases, as well as for the dissolution of gallstones, the medication is prescribed at a dosage of 10 mg / kg once daily. Treatment with the drug is carried out continuously for a long time.

If there is a throw of bile in the esophagus or stomach, the patient is prescribed 1 capsule per day. The duration of therapy is from six months to a year.

For the prevention of cholelithiasis (repeated) doctors recommend taking the medicine for several months after all the stones have dissolved.

When treating chronic liver diseases, the duration of treatment can range from a couple months to two years.

With reflux esophagitis (biliary) and reflux gastritis, medication should be taken 250 mg once a day just before bedtime. The course of such therapy is usually 10-14 days.

With biliary cirrhosis (primary), the drug is prescribed in a volume of 10 mg / kg.

The medicine we are considering can be prescribed even for young children. But you should always take into account the weight of the child.

Children with a body weight of 25-50 kg are given 1 capsule per day. As for a child weighing more than 50 kg, he is prescribed 2 capsules.

An overdose of a drug

The instruction for the use of Ursohol does not contain any information about an overdose of this drug. However, this fact does not mean that it can be taken without control and without the appointment of a doctor.

In some cases, after a misuse of the drug in question, patients may experience signs of an overdose such as diarrhea. To get rid of this symptom, you must stop taking the medication. As a symptomatic treatment, doctors recommend maintaining the balance of electrolytes and fluid in the body.

Side effects

Can the drug "Ursohol" affect the human body in a negative way? The use of this drug in a number of cases does cause some side effects. Let's consider their list right now:

  • diarrhea;
  • Allergic reactions;
  • Increase in the volume of transaminases in the blood;
  • nausea;
  • Itching;
  • Pain in the epigastric region.

Interaction with other medical devices

Can I simultaneously take the medicine we are considering with other medications? What does the attached instruction say about this? "Ursohol" is not recommended at the same time with cholestyramine, colestipol and antacids, which contain aluminum hydroxide. This is due to the fact that these medications significantly reduce the absorption process and the effect of the drug. Therefore, their simultaneous reception is inexpedient.

One can not help saying that the effectiveness of the drug under consideration is also reduced by such means as "Bezafibrate", "Clofibrate", "Probuson". This fact is due to the fact that during the reception significantly increases the secretion of cholesterol.

Among other things, the drug "Ursohol" increases the effectiveness of antidiabetic drugs taken inside.

Features of the use of the medicinal product

What do you need to know before you start taking Ursohol medication? Reviews of this drug say that it should be used only to dissolve bile cholesterol stones (i.e., x-ray negative), the size of which does not exceed 15-20 millimeters. Moreover, to carry out therapy with this medicine is allowed only with a working gallbladder, and also with the preserved patency of the common bile and cystic duct.

To monitor the effectiveness of treatment, experts recommend that every six months to conduct X-ray and ultrasound examination of bile ducts. In the event that after a lapse of six months (after the start of taking the drug), the decrease in gallstones did not occur, then there is no point in continuing the therapy.

Representatives of the weaker sex of childbearing age during treatment with this drug should use only non-hormonal contraceptives or hormonal oral contraceptives that have a reduced content of estrogen.

With long-term medication (longer than one month), you should periodically (at least once a month) take a biochemical blood test. This is necessary in order to determine the activity of hepatic transaminases (in the first 3 months of treatment).

In the event that a patient has abnormalities in the biochemical picture of the blood, doctors are required to reduce the dosage of the drug. If the parameters are not normalized within one month, the medication should be stopped.

The cost of the drug and its analogs

The price of the drug "Ursohol" varies between 180-250 Russian rubles (for 10 capsules). In view of the fact that this medication should be taken for a long time, therapy can cost the patient very dearly.

What drug should I use if you could not find the drug Ursohol? Analogues of this medicine can be found in any pharmacy. These include the following drugs: Ursofalk, Ursosan, Cheludexan, Livedoksa, Ukrliv, Urdoksa, Ursodex and Ursolizin.

Reviews about the drug

According to the patients' reviews, the drug "Ursohol" effectively dissolves cholesterol stones in the gallbladder, and also prevents their repeated formation. In addition, this drug treats various liver diseases, including its toxic lesions, acute and chronic hepatitis, cirrhosis and so on.

As for negative reviews, most often they are associated with side effects, as well as the high cost of the drug. Although experts argue that the price of this medication is fully consistent with its quality and effectiveness.

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