"Калчек": the instruction on application, analogues, responses

What do you need to know before using such a drug as "Calchek"? Instructions for the use of this medicine is mandatory for reading. In it you will find indications and contraindications to the use of this medication, and also find out if it has analogs and side effects.

Form of preparation, composition and packaging

Do you know in what form it is possible to purchase the medicinal product "Kalchek"? Instruction for use informs us that this preparation is available only in the form of tablets. The composition of the drug includes an active ingredient, such as amlodipine besylate (5, 2.5 and 10 mg). As for additional substances, they include dibasic calcium phosphate, corn starch, sodium starch glycolate, purified talc, colloidal silicon dioxide and magnesium stearate.

Tablets are in blisters (10 pcs.), Which are placed in boxes of cardboard.

Pharmacological properties of a medical device

How does the medical preparation "Kalchek" work? Instruction for use states that this medication is a selective blocker of calcium channels of the 2nd class. It has antianginal, antihypertensive, vasodilating and spasmolytic effects. The medicinal elements that make up this remedy are able to block the flow of calcium ions into the cells of smooth muscle vessels.

The antihypertensive properties of the drug are due to its direct relaxing effect on the smooth muscles of the vessels. As for the antianginal effect, the drug in question is capable of expanding the arterioles (peripheral). Subsequently, this leads to a decrease in OPSS, which, in turn, leads to a decrease in myocardial needs in O ₂ (oxygen).

However, it should be noted that sometimes, under the influence of this agent, oxygen intake, on the contrary, increases. This is due to the expansion of the coronary arteries (for example, with angiospastic angina).

It should be specially noted that the Calchek tablets do not have a negative effect on the lipid composition of the blood. They have antithrombotic and antiatherosclerotic activity, increase the filtration rate (glomerular), and also have a weakly expressed natriuretic effect.

With diabetic nephropathy, the drug is not able to increase the severity of microalbuminuria.

Pharmacokinetic properties of the preparation

Where is the absorption of the drug "Calchek"? Experts say that the absorption of this drug comes from the digestive tract (approximately 90%). Its highest concentration in the blood is observed after a lapse of 7-12 hours. The bioavailability of the drug is approximately 63-65%.

The active substance of the drug penetrates through the BBB, and also excreted together with the mother's milk. Amlodipine is biotransformed in the liver (inactive metabolites are formed).

In an unchanged form, less than 10% of the drug is excreted. As for inactive metabolites, they are excreted in an amount of 60% together with urine and about 20-25% by intestine and together with bile.

Indications for use

At what diseases the patient can be prescribed Kalchek tablets? Instructions for use (analogues of this tool are presented below) informs about the following indications:

• Stenocardia is stable;
• Unstable angina;
• Hypertension arterial (used as monotherapy or in complex therapy with ACE inhibitors, thiazide diuretics, beta and alpha-blockers);
• Angina angiospastic angina (or the so-called stenocardia of Prinzmetal).

Contraindications for use

If there are any conditions, the patient can not be prescribed Calchek tablets? The instructions for use contain the following contraindications:

• Hypotension arterial;
• Increased sensitivity to the main active ingredient of the drug.

It should also be noted that the drug can not be used in patients who have hypersensitivity to dihydropyridine derivatives.

"Kalchek" medicinal product: instructions for use

Tablets "Calchek" with stenocardia and hypertension are prescribed at a dosage of 5 mg per day. If necessary, an increase of up to 10 mg is possible.

Patients with a diagnosis such as dilated cardiomyopathy start treatment with a dosage of 2.5 mg per day. If the drug is transferred relatively well, then a gradual increase in the dose (not more than 10 mg per day) is possible.

When using tablets in combination therapy with beta-blockers, thiazide diuretics or ACE inhibitors, dosage regimen adjustment is not required.

Signs of an overdose and treatment process

What signs of an overdose occur when the medication "Calchek" is incorrectly taken? Analogues and the drug itself can cause severe arterial hypotension. As a treatment, the patient should be given a horizontal position, and slightly raise his legs. In addition, support of vascular and heart function, monitoring of pulmonary function indicators, control of diuresis and BCC is required.

To restore the vascular tone, the patient is given vasoconstrictive medications. To eliminate the effects of calcium channel blockade, the patient is given (intravenously) calcium gluconate.

Drug Interactions

Simultaneous reception of "Kalchek" tablets and "Warfarin" does not cause a significant change in the prothrombin period in healthy men.

With the simultaneous use of the medication in question and the "Digoxin" medication, there are no changes in the concentration of the drug in the blood, as well as its renal clearance.

Simultaneous administration of "Calchek" and "Cimetidine" drugs does not have any effect on the pharmacokinetic properties of amlodipine.

Lactation and pregnancy

Is it possible to take Kalchek tablets during lactation and gestation? Instructions for use, reviews of doctors inform that the effectiveness and safety of this drug during pregnancy and breastfeeding of the baby are not established.

Side effects of the drug

What side effects can cause tablets "Calchek"? Instructions for use of this tool confirms the fact that its reception can cause unwanted reactions in the body. Among them, the following are especially common:

• Vessels and heart: shortness of breath, palpitations and hot flashes.
• Nervous system (peripheral and central): mood changes, dizziness, muscle cramps, headache, visual impairment, drowsiness, asthenia, fatigue, paresthesia and myalgia.
• The digestive tract: abdominal pain, indigestion, cholestatic jaundice, nausea, increased activity of transaminases (hepatic).
• Skin covers: erythema multiforme, itching, skin rash.
• Others: gingival hyperplasia, gynecomastia, frequent urination, impotence and swelling.

Special instructions for taking medication

What nuances of the drug should be known before taking the Kalchek tablets? Experts say that this medication should be used with extreme caution in people with impaired liver function, as well as heart failure (chronic) and stenosis of the aortic estuary.

Simultaneous reception of the drug "Kalchek" with non-steroidal agents, nitrates, antibiotics and hypoglycemic drugs (oral) is possible.

The experience of clinical use of the drug in young children is absent.

The Calchek tablets do not have any effect on the patient's ability to drive.

Terms and conditions for storage of the preparation

The preparation "Kalchek" (5, 10 and 2.5 mg) should be stored in a cool, dry and protected from light place, inaccessible to small children. Shelf life of the tablets is 2 years.

Reviews about the drug, its analogs and cost

How can you replace such a tool as "Kalchek"? Analogs of this drug are available in almost all pharmacies. Among the most common remedies are the following medicines: Agen, Tenox, Adipin, Stamlo, Acridipine, Omelar Cardio, Amlo, Normodipin, Amlodipine, Norvasc, Amlovas, Amrolus, Norvadin, Amlodigamma, Cordy Cor, Amlodil, Corvadil, Amlodifarm, Karmagip, Amlocard-Sanovel, Cardilopin, Amlong , "Vero-Amlodipin", "Amlotop", "Amlonorm".

What is the cost of the funds in question? The average price of this drug is 175-190 Russian rubles (5 mg, 30 tablets).

As for the patients' opinions, in their majority they are positive. According to those who have ever used this medication, it effectively fights with angina and hypertension. It should also be noted that a large number of patients are pleased with the fact that this drug is relatively well tolerated by them. Although in some cases, the Calchek tablets still cause such side effects as headaches, abdominal pain, dizziness, nausea and allergic reactions to the skin.