The drug "Roxithromycin": instructions for use, description, analogues, reviews

In what dose do patients get Roxithromycin? Instructions for the use of tablets will be described later. Also from the article you will learn about the cost of this drug, whether it has analogs, what are the side reactions and contraindications.

Composition, description, form of the medicinal product

The tablets "Roxithromycin" are covered with a film coating, they have white color, and also a round and biconvex form with an engraving "164".

The active substance of this medicine is roksitromitsin. In addition, the preparation also includes such auxiliary components as giprolose, povidone K30, poloxamer, magnesium stearate, colloidal silicon dioxide, corn starch and talc.

As for the film shell, it contains hypromellose, dextrose, titanium dioxide and propylene glycol.

The drug is sold in blisters and cardboard packs, respectively.

Pharmacological characteristics of antibiotic tablets

How does the drug "Roxithromycin" affect the body? The instruction for use says that it is a semi-synthetic antibiotic belonging to a group of macrolides that has a broad spectrum of antibiotic activity.

The drug has a bacteriostatic effect. It binds to the 50S subunit of the ribosomes, slows the synthesis of the protein by ribosomes, suppresses the reactions of transpeptidation and translocation, as well as the formation of bonds between the peptide chain and amino acids. Such an effect promotes inhibition of growth and reproduction of bacteria.

The antibiotic "Roxithromycin" penetrates into the cells well and quickly, which ensures its high effectiveness against intracellular pathogens.

Pharmacokinetics of the drug

Where is the absorption of the drug "Roxithromycin"? Experts say that after oral intake of the drug is absorbed from the digestive tract.

Tablets are stable in the acidic environment of the stomach. Food consumed in ¼ hours after the drug has no effect on its absorption.

After taking the drug, its maximum concentration is reached after a lapse of a half to two hours.

Use of the medication with an interval of 13 hours ensures the preservation of the necessary concentrations of the drug in the blood throughout the day.

The connection with plasma proteins is 95.5%. In this case, the drug penetrates into the lungs, the prostate gland and palatine tonsils. It is also found in cells (macrophages) and in various body fluids.

"Roxithromycin", the price of which is indicated below, practically does not penetrate the blood-brain barrier and is released together with mother's milk only in small amounts. Despite this, it is prohibited to take this medication at such periods.

The drug is partially metabolized in the liver. Its largest part (about 50%) is excreted unchanged in the intestine, as well as by the kidneys (about 12%) and light (about 15%).

The half-life of the active substance after a single dose is approximately 13 hours.

With poor liver function, the maximum concentration and half-life of the drug increases.

Indications for antibiotic use

What is the purpose of the pill "Roxithromycin"? The instruction for use states that this agent effectively treats infections that have been caused by pathogens that are sensitive to the active agent.

For adults, the medication is prescribed for:

• Tonsillitis, pharyngitis, acute sinusitis;
• Infections of soft tissues and skin;
• Pneumonia, bronchitis;
• Infections of the urinary tract;
• Infections in odontology (teeth and oral cavity).

"Roxithromycin" for children is prescribed for:

• Pharyngitis, tonsillitis, acute sinusitis;
• Pneumonia, bronchitis;
• Infections of soft tissues and skin.

Contraindications to the use of an antibiotic

In what cases is the patient not prescribed the drug "Roxithromycin"? Instruction for use informs about the following prohibitions:

• Increased sensitivity of the patient to roxithromycin or macrolides in general, as well as other substances of the drug;
• Porphyria;
• Period of pregnancy;
• Simultaneous reception with "Cisapride", "Terfenadine", "Pimozide" and "Astemizol";
• Body weight less than 40 kg;
• The period of breastfeeding;
• Complex use of vasoconstrictor ergot alkaloids (dihydroergotamine and ergotamine);
• Age up to 12 years.

Cautionary appointment of tablets

The drug "Roxithromycin", analogues of which will be indicated below, with caution appoint to people with hepatic and renal insufficiency, elderly patients, as well as patients with conditions that contribute to the occurrence of violations of the heart rhythm, and with an innate lengthening of the QT period.

Dosage of the drug to adults and children

Tablets are administered orally before meals. For adults and children over 12 years of age, the standard dosage is 150 mg twice daily with an interval of 13 hours or 300 mg once (for adults).

In elderly people, the daily and single dose of the medication does not change. Patients with renal insufficiency drug prescribed in a dose of 150 mg twice a day.

In patients with hepatic insufficiency, the dosage is halved (up to 150 mg once a day).

Duration of treatment for adults and children

How long does the drug "Roxithromycin" take? The duration of treatment depends on the indications, as well as the microorganism that caused the infection, and the severity of the disease.

In adults, the standard course can take about 5-10 days. In infections that were caused by beta-hemolytic streptococcus, therapy should last at least 10 days.

As for children, the duration of the course is also 5-10 days.

Overdose of a medicinal product

When taking higher doses of medication, the patient may have increased dose-related side effects. As a treatment for such conditions, symptomatic therapy and gastric lavage are used.

Side effects

On the background of taking the drug in question, the patient may experience the following side effects:

• Nausea, abdominal pain, vomiting, diarrhea, pseudomembranous colitis, pancreatitis;
• Increased liver transaminase activity, acute hepatocellular or cholestatic hepatitis;
• Paresthesia, dizziness, changes in taste, headaches, odor disorders, temporary hearing loss, hallucinations, vertigo, hypoacusia;
• Redness, rash, purpura;
• Angioedema, bronchospasm, urticaria, eosinophilia;
• Shock anaphylactic, exudative erythema multiforme ;
• Superinfection, candidiasis.

Special Recommendations

People with liver failure should be treated with extreme caution.

With the development of allergic reactions and superinfection, the drug should be discontinued and the patient should be given appropriate therapy.

When taking the medication, and also two to three weeks after the treatment, the patient may develop diarrhea caused by pseudomembranous colitis.

The drug "Roxithromycin" and alcohol should not be combined.

Drug Interactions

The medication in question is not prescribed with drugs that contain dihydroergotamine or ergotamine, as this can cause arterial spasm.

It is not recommended to take "Roxithromycin" with "Terfenadine" because of the increased risk of complications from the cardiovascular system.

With the simultaneous reception of this drug with digoxin, its absorption can increase, which will lead to the development of glycosidic intoxication.

The combination of "Cyclosporine" or "Theophylline" with "Roxithromycin" can cause an increase in the plasma concentration of the latter.

Drug analogues

The most popular analogue of "Roxithromycin" is "Erythromycin". The instruction says that this preparation is also an antibiotic.

So which of these funds is better? In comparison with "Erythromycin", "Roxithromycin" has more improved pharmacokinetic properties. After oral administration, it is quickly absorbed from the digestive tract.

Having more advanced bioavailability, which is weakly dependent on eating, this medication is found in the blood after ¼ hours.

Also it should be said that the drug "Roxithromycin" forms more tangible and reliable concentrations not only in human fluids and tissues, but also in blood serum.

Thus, it can be safely noted that the first drug is slightly worse than the second one. "Erythromycin", the instruction of which is also embedded in a cardboard pack, is an obsolete antibiotic.

In addition to the aforementioned drug, the drug "Roxithromycin" can be replaced with drugs such as Brilid, Esparoxy, Vero-Roxithromycin, Elroks, Xitrocin, Rusbrikar, Remora, Rulitsin, Rokseptin, Rulid, Roksigeks, Romik, Roksid, Roksolit, Roksilor, Roksitromitsin DS, and Roksimizan.

Medication price

How much is the antibiotic "Roxithromycin"? The price of this medication is quite high. You can buy it in pharmacies for 550-600 rubles.

Patients' comments about the medicine

The antibiotic "Roxithromycin" is a rather popular drug among patients. Therefore, there is a fairly large amount of feedback on this tool. Most people report that this medication manifests itself as a very effective antibiotic drug. In combination with other drugs, it fights various infections of the lower and upper respiratory tract (tonsillitis, pharyngitis, acute sinusitis), as well as the genito-urinary tract, soft tissues and skin.

Along with positive reviews, this remedy has negative ones. Most often, the latter are associated with side effects, which manifest themselves against the background of taking the medication in question. Some patients complain of a feeling of nausea, severe diarrhea, headaches, vomiting, exacerbation of pancreatitis and a rash.

If such symptoms appear, doctors recommend that you stop taking the pills and consult a doctor who is supposed to advise a safer medication.

It should also be noted that there are many reviews that this drug has an overestimate value. Patients argue that the analogs of this drug are much cheaper and at the same time are not inferior to it in effectiveness.