The drug "Molsidomin": instructions for use, price, analogues

Angina is called a disease characterized by a feeling of discomfort and unpleasant sensations arising behind the sternum. Experts say that such pain occurs unexpectedly under stress, after a meal or under physical stress. Usually it gives to the lower jaw, neck area, subscapular region, left shoulder and lasts for an hour. This condition disappears immediately after the termination of the load or taking special medications.

Very often with stenocardia patients take the medication "Molsidomin." Its analogues, instructions, indications and properties are described below.

Form, packaging, composition

The drug "Molsidomin LF" goes on sale in the form of orange or pink tablets of flat and round shape with bevelled edges. They contain 2 or 4 mg of molsidomine. In addition, the composition of the drug includes auxiliary components (povidone K-25, potato starch, sucrose, food color, lactose, magnesium stearate).

This drug is sold in blisters, which are placed in cardboard packages.

Features of the medicine

This drug is referred to vasodilators, that is, drugs that dilate the vessels. After its administration, the venous inflow to the heart muscle decreases, as well as the venous tone. This helps reduce the pressure in the pulmonary artery and myocardial tension.

Operating principle

How do Molsidomine tablets work? Instruction for use says that the effect of this medication is due to the action of the metabolite of its active substance - lansidomine. This element affects the smooth muscles of the vessels, reducing their tone. In addition, it exhibits antiaggregant properties.

As soon as the tonus of smooth muscles decreases, the volume of the vascular bed increases and the pressure in the cardiac ventricles decreases. As a result of this effect, the load on the heart and its need for oxygen decreases.

One can not help saying that under the influence of molsidomine, spasms of the coronary arteries decrease and their branches expand. Thus, the blood supply to the heart is greatly improved.

Kinetics of the preparation

Medication "Molsidomin", the price of which is indicated below, is absorbed in the digestive tract by 90%. Its bioavailability is 65%, and only 11% bind to plasma proteins.

The effect of the drug begins to manifest after 20 minutes and lasts about 6 hours. After another 30-50 minutes, the concentration of the drug in the blood reaches its maximum.

Molsidomin tablets, the instructions for use of which are listed below, are transformed in the liver. There is an enzymatic way. The main substance of the drug is converted to sidnonimine 1, which later turns into lansidomine. It is this metabolite that ensures the action of the drug.

The medicine in question is excreted from the body together with the urine for one and a half to two hours.

Indications

Molsidomine tablets are indicated for administration in the following cases:

• Prevention of angina attacks;
• Therapy of pulmonary heart failure;
• Elimination of already developed attacks of angina pectoris.

Prohibitions for admission

The medicine in question can not be taken with the following pathologies and conditions:

• Severe hypotension;
• Lactation period;
• glaucoma;
• pregnancy;
• Myocardial infarction (in acute phase), especially with lowered arterial pressure;
• Cardiogenic shock;
• Violation of carbohydrate metabolism.

Use of medicament for acute myocardial infarction is permissible only with regular monitoring by the doctor.

Molsidomin tablets: instructions for use

The dosage and use of this drug depends on the available indications.

For the prevention of angina attacks, the drug is prescribed for 4-12 mg per day. It is taken orally after a meal.

When using medicament for medicinal purposes, it is prescribed for 1-2 mg daily in 4-6 receptions. If required, the dosage is increased to 2-4 mg. At the same time, the number of receptions is reduced to 2-3 times a day.

To eliminate the already developed attack of angina pectoris should be placed under the tongue.

Adverse events

Precautions for taking the drug in question should be observed by all patients. This is due to the fact that during treatment, the following undesirable effects may appear in a person:

• nausea;
• Lowering blood pressure, especially with a sharp rise;
• Headaches that develop at the very beginning of treatment;
• Redness of facial skin;
• Rash (appears very rarely).

Precautionary measures

In the usual situation, the hypotensive effect of this drug is poorly expressed. However, when combined with other vasodilators or during therapy of people with a reduced volume of circulating blood or arterial hypotension, special care should be taken.

Elderly persons with impaired liver or kidney function are required to prescribe reduced doses of the drug.

Cost and substitutes

Now you know how to use Molsidomin tablets. Instructions for use of the drug were presented above.

The cost of this medicine is 90-100 rubles for one package. If required, it can be replaced with drugs such as Dilasidum or Sidnofarm.

Consumer Reviews

There are many reviews of the tablets "Molsidomin." In most of them, consumers claim that this drug in a short time helps to eliminate the severity of clinical manifestations of angina and heart failure. Also, many patients are pleased with the low cost of this drug and its availability in all pharmacies. To the disadvantages carry only negative reactions, but the same can be said about the majority of medications.