"Sumatriptan": instruction manual, reviews. Analogs of the drug "Sumatriptan"

Why is the drug Sumatriptan intended? Instructions on the use of this drug, its pharmacological action, composition and form of release will be presented below. Also in this article we will tell you about what contraindications, indications and side effects this medication has, what are its methods of application and dosage, whether it has analogues and so on.

Composition of the medicinal preparation and its form of release

Currently, the pharmacy can only find tablets and nasal spray "Sumatriptan". Instructions for use of this product provides complete information about the composition of this drug. You can learn it right now.

Tablets in a film shell contain an active substance such as sumatriptan succinate. As for the auxiliary elements, they include the following: calcium hydrophosphate dihydrate, microcrystalline cellulose, giprolose (or hydroxypropyl cellulose Klucel LF), magnesium stearate, mannitol (or mannitol), croscarmellose sodium (or impellosis).

Sumatriptan also acts as active substance of the nasal spray Sumatriptan. As for the auxiliary components, they can be changed in accordance with the form of release of the drug. It should be specially noted that the spray is used for treatment much less often than tablets. However, they also have their own consumers. Typically, these are those patients who are uncomfortable taking the drug orally.

Pharmacological characteristics of the drug

What features are the "Sumatriptan" tablets, which we will consider further?

The said preparation is an antimigraine agent. It is a selective and specific agonist of 5-HT1-serotonin receptors that are localized in the blood vessels of the brain. It should be noted that the drug does not affect other subtypes of 5-HT-serotonin receptors in any way.

After taking the drug, it causes narrowing of the vessels belonging to the carotid arterial bed. Thus, the drug "Sumatriptan" (tablets) supplies blood intracranial and extracranial tissues. It should be noted that it is the expansion of the vessels of the meninges, as well as their edema, that are the causes of the development of migraine in man.

One can not help saying that after taking this drug does not have a significant effect (negative) on the cerebral blood flow. Tablets only suppress the activity of the receptors of the afferent fibers (their endings) of the trigeminal nerve, which is located in the dura mater. This is due to a decrease in the isolation of sensory neuropeptides.

It should also be said that the drugs "Sumatriptan" and "Sumatriptan Teva" completely eliminate photophobia and nausea, which are directly related to migraine attacks.

Effectiveness of the drug

How quickly the positive effect after taking the drug "Sumatriptan"? The patient's comments about this medication contain information that the drug begins to act only after 30 minutes. In this case, the patient must take a dose equal to 100 mg. By the way, it is in 50-70% of cases that migraines are quickly eliminated in patients after using 25-100 mg of the drug. Within a day, a third of patients develop a relapse that requires repeated use of the drug.

Pharmacokinetics

How long does the drug Sumatriptan take? The answer to this question is also contained in the instructions for using the tool. After taking the medicine inside, it is almost immediately absorbed in the digestive tract. After about 45 minutes, the concentration of the drug substance in the blood serum reaches about 70%.

Due to incomplete absorption and presystemic metabolism, the absolute bioavailability of the drug when ingested on average is 14%. As for binding to blood plasma proteins, it is very low (about 15-21%). The half-life is about 2 hours. The drug is excreted mainly through the kidneys.

Absorption of the drug in special clinical cases

According to specialists, migraine attacks do not have a significant effect on the absorption of active substance sumatriptan (when ingested or intranasally administered).

If the patient has impaired liver function, then after using the drug, he may have an elevated level of the active component in the plasma. This occurs as a result of lowering the pre-system clearance.

Indications for use of the medicine

In what cases is the medicinal product Sumatriptan administered? The instruction on the use of this drug says that it must be taken only in cases of migraine attacks (without an aura or with it).

Contraindications to use

In the presence of any deviations, it is strictly forbidden to take "Sumatriptan" medication, analogues of this drug? I would like to especially note that the instruction contains a lot of information on this matter. That's why before taking the drug with it should be familiarized.

So what contraindications does the drug have? Let's consider the list right now:

• Increased sensitivity of the patient to the elements of the drug;
• Elderly patient (over 65 years old);
• Basilar, ophthalmoplegic or hemiplegic form of migraine;
• Simultaneous administration of the drug with medications that contain ergotamine, its various derivatives, as well as MAO inhibitors (it is forbidden to take the drug for up to 14 days after the withdrawal of the drugs);
• Ischemic heart disease, as well as suspected of it;
• Adolescence and children's age (up to 18 years);
• Angina pectoris, including angina of Prinzmetal ;
• Pregnancy and breastfeeding;
• Myocardial infarction, including those that occur in the anamnesis;
• Arterial hypertension (uncontrolled type);
• Arterial hypertension (controlled type);
• Occlusal diseases of peripheral arteries;
• Epilepsy, including any pathological conditions associated with a reduced epileptic threshold;
• Renal or hepatic impairment;
• Stroke, or a transient condition of cerebral circulation, including those taking place in the anamnesis.

As mentioned above, the drug "Sumatriptan" during pregnancy is prohibited. But if the risk to the fetus is less than the benefit to the mother, it is still prescribed to women in the position and nursing mothers. However, only an experienced specialist should do this (the drug is taken strictly under his supervision). By the way, it is extremely not recommended to breastfeed during the day after taking these pills.

Medicinal remedy "Sumatriptan": instructions for use

This drug is taken orally, regardless of food intake. Dosage in this case should be equal to 50 mg (if necessary - 100 mg).

If you decide to apply the nasal medication Sumatriptan (spray), then its dose is 20 mg in each nasal passage. Repeated administration of the drug is allowed no earlier than 2 hours later.

The maximum daily dosage for oral administration is 300 mg. With intranasal use of the drug, it is equal to two doses of 20 mg.

Features of the drug

Now you know how to defeat a migraine. "Sumatriptan" (tablets and spray) copes well with the task. However, it should be noted that this medication is not intended to prevent this deviation.

Use of the drug is possible only if the diagnosis is not in doubt. Before the appointment of "Sumatriptan" to patients with atypical and previously not diagnosed migraine, the doctor must necessarily exclude other dangerous neurological conditions. It should also be taken into account that in patients with the above diagnosis after the taking of tablets, the development of a cerebrovascular disorder is possible.

The presence of abnormalities in the circulatory system (in men over 40 years and in women in the postmenopausal period) requires a preliminary examination in order to exclude pathology from the heart and blood vessels.

Currently, there are reports of the appearance of coordination disorders, weakness and hyperreflexia after taking the drug "Sumatriptan" and other drugs from the group of selective inhibitors.

Before and during treatment, the drug presented requires a constant intake of food, as well as compliance with a strict diet. Thus, the patient is recommended to exclude from his diet products that contain the substance tyramine (chocolate, citrus, cocoa, celery, nuts, cheeses, beans and tomatoes). In addition, it is necessary to refuse the use of alcoholic beverages, including red, sparkling and dry wines, champagne, beer.

Playing sports and leading a healthy lifestyle in general (walking, swimming, skiing), as well as the presence of a hobby, contribute to the emergence of positive emotions, which prevents the development of migraine attacks in a sick person.

Instructions for use of nasal spray

The trade name of the spray with active substance sumatriptan sounds like "Imigran". This medicine has the following parts:

• A finger clip;
• tip;
• Blue button.

It should be specially noted that the blue button works very quickly and only once. In this regard, it is not recommended to press it until the tip is inserted into the nasal passage. Otherwise, the entire dose will be wasted.

To use the nasal spray, the patient needs to take a comfortable lying position, standing or sitting. By the way, it is recommended to clean the nasal cavity of the patient with cotton buds.

After removing the blister pack and taking out the medication for nasal use, the drug is required to be inserted into one nostril. As for the other nasal passage, it should be pressed with a finger to the nasal septum. In this case, the patient should breathe freely through the mouth.

Insert the tip of the nasal drug into the nostril should be 1 centimeter. The head of the patient should be kept straight, and not tipped back. After this, the patient should close his mouth and, by making a calm and slow breath through his nose, with a simultaneous effort to press the blue button with his thumb. In this case, a person may think that the button is very tight. But this is not so. During the injection of the drug in the nasal cavity, the patient should hear a faint click. This means that the button has worked successfully.

After the described actions the patient needs to open his mouth and breathe through it slowly. The head should still be kept straight. Then the patient should take a quiet breath through the nasal cavity, and then exhale through the mouth (for 10-20 seconds). It is not recommended to breathe too deeply.

After the procedure for injecting the drug is completed, a person can sense the presence of moisture in the nose, as well as a slight taste. These sensations are not dangerous to health and very quickly pass spontaneously. After a single use, the dispenser can be discarded.

Special instructions when using

Sumatriptan Teva, whose reviews are more positive, should be taken with special care by drivers of vehicles, as well as those who engage in hazardous activities, which require an increased speed of reactions and special attention.

Adverse events

Can the drug Sumatriptan cause side effects? Drugs of this type can contribute to the development of a rather large number of negative phenomena. Let's consider them in more detail:

• Human blood circulation system. On the part of this system, the patient may have decreased blood pressure, myocardial infarction, temporarily high blood pressure (usually soon after taking), heart palpitations, bradycardia, tachycardia, and in some cases, arrhythmia, coronary artery spasms, transient ECG changes, Raynaud's syndrome.
• Nervous system and sense organs. After taking the drug, a person may experience fatigue, dizziness, weakness and drowsiness. In some cases, the drug causes diplopia, convulsive attacks, the appearance of flies flies before the eyes, nystagmus, reduced visual acuity, cattle and partially transient loss of vision.
• The digestive tract. On the part of digestion, the patient often experiences vomiting, dysphagia, nausea, as well as an increase in (negligible) activity of liver enzymes, abdominal discomfort and ischemic colitis.
• Allergy. After taking the medication, some patients note the occurrence of itching, rash, hives and erythema. Anaphylaxis, a feeling of heat, tingling and pain in the head, heaviness, pressure, flushing of the face and myalgia are also observed. With intranasal administration of the drug, local reactions can occur in the form of a light transient feeling of irritation or burning in the pharynx and nasal cavity, as well as epistaxis.

Interaction with other medicinal products

How do other medicines affect the effectiveness and effect of Sumatriptan? Instruction, expert feedback on this account contain the following information. With simultaneous use of the drug with "Ergotamine" medication, as well as ergotamine-containing drugs, the patient can have a long vasospasm. In this regard, the interval between doses of these drugs should be at least 24 hours.

According to studies, there is an interaction between the drug "Sumatriptan" and MAO inhibitors. At the same time, the intensity of metabolism of the former decreases, and its concentration increases.

With the simultaneous use of this remedy against migraine attacks and drugs belonging to selective serotonin reuptake inhibitors, the patient may develop weakness, hyperreflexia, and impaired coordination of movements.

Drug overdose (symptoms, treatment)

What happens if you do not follow the dosage recommended by your doctor? With excessive use of the drug "Sumatriptan" in patients, it is possible to increase the above-mentioned adverse reactions. In this regard, their condition requires special supervision for 10 hours.

If necessary, an overdose of the patient is assisted in the form of symptomatic treatment.

Sumatriptan: analogues and the price of a medicinal product

You can purchase this tool in any pharmacy. It should be noted that the price of the drug "Sumatriptan", compared with others, is relatively low. So, for 50 tablets in a film shell you will have to give only 170-200 Russian rubles. As for the nasal drug, its price is about the same.

Are there any analogues for Sumatriptan? "Amigrenin" is a drug that is most often purchased for the removal of migraine attacks, if there was no aforementioned remedy in the pharmacy. In addition to this, Sumatriptan medicines with the active substance are analogues of the following medicines: Sumarin, Imigran, Sumitran, Migrapam, Sumatriptan-Teva, Sumatriptan succinate, Sumatriptan Pfizer, Sumatriptan Adifarm "," Sumygren "," Trimigrene "and so on.

Also, as a similar nasal agent, some experts recommend using the spray "Imigran".

Storage conditions and shelf life

The presented preparation should be stored exclusively in a dry place and protected from sunlight. In this case, the temperature in the room should not be more than 25 degrees. Shelf life of the medicine is 3 years. After this period, the drug should not be used.