Sodium oxybutyrate (gamma-hydroxybutyric acid GOMK) is a hypnotic of metabolic action. This drug was used in anesthesiology. According to A. Labory (a French surgeon), sodium oxybutyrate allowed to achieve a new surgical anesthesia. The mechanism of action of the drug was based on the direction of cellular metabolism, and not on its destruction.
Sodium oxybutyrate has a low intrinsic analgesic activity, but it can enhance the effect of neuroleptics, analgesics and other means for anesthesia.
GHB has extremely low toxicity. This circumstance concerns the conditions of the intensive care chambers operating and operating rooms, where the problems of suppression of the center of respiration and central muscle relaxation at excessively high doses are solved by professional equipment to ensure ventilation and patency of the respiratory tract. Out-of-hospital admission GOMKa is characterized by more stringent criteria of toxicity.
Sodium oxybutyrate is quite effective both in intravenous and rectal, oral and intramuscular administration. Rapid injection into the vein can be accompanied by twitching of the convulsive muscles.
After entering the body, GHB is included in the metabolism completely. As a result, the drug decomposes to carbon dioxide and water. A small amount of GHB is excreted in the urine.
The use of sodium oxybutyrate does not cause addiction and addiction, there is no hangover syndrome. With the introduction of the drug, the patient falls asleep pleasantly and easily, the dream is considered refreshing, full.
The medication is characterized by a pronounced "dose-effect" curvature (doubling the dosage leads to an intensification of the effect fourfold). In therapeutic volumes, it practically has no inhibitory effect on the respiratory center.
GHB is considered the most potent stimulant of the pituitary gland of all known. Admission (single) is accompanied by a short (up to several hours) increase in the concentration of growth hormone ten to fifteen times.
The use of sodium oskibutyrate contributes to an increase in the threshold of cardiac fibrillation.
GHB refers to anabolic direct and indirect effects. The drug can be used with parenteral nutrition, as it causes a decrease in protein decay. The necessary dosages for this are considered to be 8-12 grams per day.
GHB has the ability to significantly lower the concentration in the blood of cholesterol. The medication is a powerful antihypoxant (a remedy that increases the resistance of the body to lack of oxygen), a radioprotector. The drug contributes to a significant increase in mesenteric blood flow and the development of hypothermia.
Some of the properties listed above caused the GOMK to be widely used at one time as a biological additive (food). It was in this capacity that the drug could be purchased quite freely without prescriptions in Western European countries and America. However, due to the fact that after a certain time GHB began to be used as a psychotropic drug, it was withdrawn from free sale. Moreover, for non-medical use of the drug sodium oxybutyrate, manufacturing in large quantities, criminal liability is provided.
An overdose of a medicine comes very quickly. For example, an additional one-fourth of a gram instead of euphoria provokes vomiting. The combination of GHB with other psychotropic substances can lead to the most serious consequences.
Sodium hydroxybutyrate. Instructions
For intravenous administration of excitable and strong (physically) patients, the dosage calculation is performed depending on the body weight (70-120 grams per kilogram). The narcotic state comes in four to six minutes after application, after which the anesthesia is deepened with an additional 40 g / kg.