Glycosylated hemoglobin and its physiological significance

The main criterion for the treatment of diabetes is to achieve a stable physiological concentration of sugar (glucose) in the blood. Control of blood sugar can be done at home using portable glucometers, as well as in a laboratory. On single results of the study of the concentration of glucose in the blood it is impossible to judge the state of carbohydrate metabolism in the body. Today, a method has been developed for determining the amount of glycosylated hemoglobin, with the help of which it is possible to assess the state of carbohydrate metabolism. Numerous studies conducted by the DCCT (Diabetes Control Committee and its clinical complications) found that the glucose level positively correlates with the patient's glycemia. Glycosylated hemoglobin is a qualitative indicator of the effectiveness of therapeutic treatment for diabetes mellitus.

Glycosylated hemoglobin is synthesized during the addition of hexose to the nitrogen end sections of beta-chains of globin hemoglobin class A1 (HbA1c). Synthesized HbA1c is deposited in red blood cells (erythrocytes) and stored there for one hundred and ten to thirty days (the life span of this cell). According to this indicator, you can determine the level of glycemia in the patient 2-3 months before the start of the study.

Glycosylated hemoglobin and its concentration is directly proportional to the amount of glucose in the blood. How can you determine its level in the blood? To determine this indicator, it is best to use special test-systems. Other instrumental diagnostic methods can also be used: gas-liquid and affinity chromatography, electrophoresis, immunoelectrophoresis, etc. Glycosylated hemoglobin is normal for healthy people from 4 to 6%. In patients with diabetes mellitus with hyperglycemia, glycosylated hemoglobin increases two to three times.

Hemoglobin in children is of particular importance, because in the growing body metabolism is significantly higher compared with adults. Therefore, parents should know and control the level of hemoglobin in the blood of their baby. This is necessary to prevent iron deficiency anemia. At the heart of the development of this disease is a deficiency of a ferum in the body, which takes an active part in the synthesis of hemoglobin. Oxygen starvation adversely affects the development of nervous, immune and cardiovascular systems. The most susceptible to iron deficiency anemia are children aged 9 months to 5 years.

Today, diabetes control is performed using the Accu-Chek 360 ° form. Due to this form, the attending physician records the glucose level in the blood of the patient on an empty stomach and after eating. The most effective way to reduce the concentration of sugar in the blood is the use of insulin prolonged action. The use of Accu-Chek 360 ° promotes the proper selection of the insulin regimen. Thus, we reduce the level of sugar in the blood to the physiological norm. Many experts say that using this form of diabetes control can effectively reduce the level of glycosylated hemoglobin to five to six units (physiological norm) in a few months.

Therefore, if you are diagnosed with diabetes mellitus, do not despair, drop your hands and focus on the thought that life is already over. You need to fight for your health. People with diabetes need to constantly monitor the concentration of glucose in the blood. It is much more convenient to conduct these studies at home than to stand idle in the lines of a polyclinic. Using the modern form of Accu-Chek 360 ° and glucomere, you can easily control your blood sugar.