"Dorsopt" (eye drops): instructions, reviews, analogues

Glaucoma is a fairly large group of eye diseases characterized by a periodic or constant increase in intraocular pressure, followed by the development of defects, optic atrophy and reduced visual acuity.

To treat such diseases use different drugs. The most common medication is Dorzopt (eye drops). The consumer's feedback, instructions for using this medication will be discussed below.

Packaging and Composition

What substances contain the drug "Dorzopt" (eye drops)? The active component of this drug is dorzolamide (in the form of hydrochloride). Also in the composition of the medicament are the following auxiliary compounds: benzalkonium chloride, hyetellose, mannitol, sodium hydroxide, citric acid monohydrate, distilled water.

The given preparation is issued in polyethylene flasks with a volume of 5 ml with a nozzle-dropper.

Pharmacodynamics

What are Eye Drops of Dorzopt? The instruction says that this agent is a local inhibitor of carbonic anhydrase. It has a depressing effect on the secretion of the intraocular fluid and slows the formation of bicarbonate, and also weakens the transfer of water and sodium.

This medication does not cause miosis or hemostalopia, as well as spasm of accommodation.

Pharmacokinetics

Is the drug "Dorzopt" (eye drops) absorbed? Absorption of this medication occurs through the cornea, as well as through the limbus and sclera. The indicators of systemic absorption of the drug are very low.

Getting into the bloodstream, the active substance of the drug quickly penetrates into the red blood cells with a high content of carbonic anhydrase 2.

The connection with plasma proteins occurs by 33%. The drug is converted to the N-desethylated metabolite, which is not very active against carbonic anhydrase 2, but is capable of blocking carbonic anhydrase 1.

Long-term use of the drug leads to its accumulation in erythrocytes.

The medicine is withdrawn by means of the kidneys. Its cancellation has 2 phases of elimination: fast and slow. The latter is due to the gradual release of the active component from the erythrocytes.

The half-life of the drug is about 4 months.

Indications

When do they prescribe Dorzopt? Eye drops are very effective in the treatment of increased intraocular pressure in people with ocular hypertension, open-angle or pseudoexfoliation glaucoma (including secondary).

Contraindications

When can I not use Dorsopt? Eye drops are not prescribed for:

• Hyperchloremic acidosis;
• Hypersensitivity to constituent elements;
• Severe violations of kidney function;
• At a minor age;
• In the lactation period.

With extreme caution this tool should be used:

• With diabetes mellitus;
• Patients with hepatic insufficiency;
• People with a small density of endothelial cells in the cornea of the eye (due to the high likelihood of corneal edema).

Mode of application

Appoint the treatment in question for the treatment of eye diseases should only a narrow specialist after a thorough examination of the patient. Bury the drug preferably one drop in the conjunctival sac three times a day.

When the drug is combined with local beta-blockers, the drug should be used one drop twice a day.

If the therapy of eye diseases includes several ophthalmic means, then the interval between their instillation should be at least ten minutes.

Adverse events

When using eye drops "Dorzopt" in patients the following local reactions may develop:

• Itching and burning in the eye area, conjunctivitis, paresthesia, eyelid edema, lacrimation, blepharitis, impaired vision, photophobia and superficial punctate keratitis.
• Very rarely, against the background of this drug, there are: iridocyclitis, increased corneal thickness, allergies, eye hypotension, and retinal detachment after antiglaucomatous operations.

Systemic side effects:

• Feeling of nausea, bitterness in the mouth, development of nephrourolythiasis, asthenia, migraine, malignant exudative erythema, toxic epidermal necrolysis, aplastic anemia, skin rashes and agranulocytosis.

Cases of overdose

What are the symptoms when using increased doses of Dorzopt? Eye drops, analogues of which are presented below, can contribute to:

• Development of acidosis;
• Violation of water and electrolyte balance;
• Violations of the central nervous system.

To treat such conditions, symptomatic therapy is used, accompanied by control of the electrolyte level and blood pH.

Drug Interactions

• When the drug is combined with antiglaucoma drugs (beta-blockers, "Dipyvefrin", "Pilocarpine", "Carbachol"), its effect is enhanced.
• With "Acetazolamide", the risk of systemic side effects increases.
• With greater dosages of acetylsalicylic acid, the toxicity of the drug increases.

Special Recommendations

The use of multi-dose vials can provoke the development of bacterial keratitis. This is due to the unintentional contamination of their contents.

In the process of treatment Doorsopt should not use lenses, since benzalkonium chloride can be toxic and cause eye irritation.

Analogues and price of medicine

To replace the considered preparation for eyes it is possible by such means, as "Trusopt" and "Floksal". The price of this medication is about 350 rubles.

Customer Reviews

Unfortunately, consumer feedback about the drug "Dorzopt" is rare. Among the main advantages of this medicine are noted such as accessibility and effectiveness. However, some consumers are concerned about local and systemic adverse reactions that occur when droplets are applied. In this regard, specialists can recommend the use of a drug called Dorzopt Plus.

The eye drops mentioned above include an additional substance, such as timolol. It promotes the outflow of intraocular fluid.