But-shpa - instructions for use.

Dosage form

The drug can be produced in two forms - tablets and solution for injections.

Biconvex, round tablets, with orange or greenish tint of color. On each side of the tablet is labeled "spa".

Composition:

Substance:

• Drotaverina hydrochloride - 40 mg (in 1 table).

Excipients:

• corn starch;
• Magnesium stearate;
• Lactose monohydrate;
• Polyvidon.

But-shpa in ampoules. The instruction says that the drug solution can be designed for both intramuscular and intravenous infusions. The solution is greenish-yellow, transparent.

Composition:

Substance:

• Drotaverina hydrochloride - 20/40 mg (in 1 ml or in 1 ampoule, respectively).

Excipients:

• Ethanol 96%;
• Sodium metabisulfite;
• water for injections.

Pharmacological action of the drug "No-shpa"

The instruction says that no-spa is a myotropic antispasmodic. The main active ingredient drotaverin is a derivative of isoquinolone and shows a smooth muscle spasmolytic effect, which is carried out by inhibiting phosphodiesterase 4. Inhibition of this enzyme can lead to an increase in the content of cAMP in the blood, which can inactivate the chain of myosin kinase. It is the latter that leads to smooth muscle relaxation.

The enzyme that hydrolyses cAMP in smooth muscle cells of the myocardium and blood vessels is an isoenzyme of phosphodiesterase 3 - this shows a rather high efficacy of the drug as antispasmodic because it does not have a pronounced effect on CCC, as well as undesirable cardiovascular effects.

But-shpa is effective for smooth muscle spasms of both muscular and neural etiology. In addition, regardless of the type of vegetative innervation, the drug can act on the smooth muscle structure of the biliary tract, gastrointestinal tract, vascular and genitourinary systems. But-shpa can also improve the blood supply of tissues, thanks to its vasodilating effect.

But-shpa - the testimony

It is used as a primary remedy for the following diseases:

• cholecystitis;
• cholelithiasis;
• Pericholecystitis;
• Cholangitis;
• Papillitis;
• cystitis;
• pyelitis;
• Tenesmus of the bladder;
• And to increase the rate of cervical dilatation.

It is used as an auxiliary for the following diseases:

• gastritis;
• Spasms of the cardia;
• Spasms of the pylorus;
• colitis;
• Enterocolitis;
• Stomach ulcers;
• Ulcers of the duodenum;
• Dysmenorrhea;
• headache;
• Strong labor pains.

Side effects of the drug no-shpa

The instruction describes all possible side effects in relation to various systems and organs.

Possible side effects of the drug from the gastrointestinal tract:

• constipation;
• nausea.

Possible side effects of the drug from the side of the central nervous system:

• insomnia;
• Dizziness;
• headache.

Possible side effects of the drug on the part of the CCC:

• arterial hypertension;
• tachycardia.

Other side effects:

• Allergic reactions to components are possible.

Contraindications to the drug but the spine

The instruction describes the following types of contraindications:

• Hepatic or renal insufficiency;
• heart failure;
• Age up to 1 year;
• Sensitivity to drotaverine or other substances in the drug;
• With arterial hypotension the drug should be used with caution.

Enter the drug is necessary for the patient only in a supine position, because in this case there is a risk of collapse.

Overdose with no-shpa preparation

The instruction does not have information about cases of overdose with this medication.

Drug interaction with other drugs

When used simultaneously with levodopa, no-shpa reduces its antiparkinsonian effect.