What is hypertension? Many people know the answer to this question, especially the elderly. As you know, this is a persistent increase in blood pressure, which indicates such indicators as 150/90 mm Hg. Art. and higher.
It is generally believed that hypertension is the most common disease of the cardiovascular system. A persistent increase in blood pressure is observed in 25-30% of the adult population. By the way, with age, this disease is noted in 55-65% of people.
Why arterial hypertension? This phenomenon can develop due to a variety of reasons. Most often in elderly people the pressure rises due to psycho-emotional overstrain. Therefore, people prone to hypertension should be as calm as possible.
One can not but say that such a disease often arises from sedentary lifestyles, age, sex (more often in the representatives of the weaker half of humanity), excessive consumption of table salt, hypocalcemia diet, alcohol abuse, heredity, obesity, smoking, diabetes and Etc.
Is it necessary to treat arterial hypertension? Doctors say that if you feel unwell, the patient should definitely take drugs that lower blood pressure. To one of them carry such a medicine as "Amlodipine". Side effects of this tool, its features, cost and analogues are indicated below.
Description of the medicinal product, its composition and packaging
In what form are the medicines "Amlodipine" manufactured, the price of which is presented below? The drug in question is produced in the form of white tablets and a flat-cylindrical form. Its active ingredient is amlodipine.
This drug is sold in contour cells (10 tablets), which are packaged in cardboard packages.
The mechanism of action of a drug
What is good about Amlodipine? According to the instruction, this drug shows pronounced antihypertensive and antianginal properties. In addition, it does not allow calcium ions to penetrate membranes into vascular cells and myocardial cells.
What is the drug "Amlodipine"? What helps this medicine? It well reduces high blood pressure. This is due to the ability of the drug to dilate the blood vessels.
It should also be noted that the drug in question has an antianginal effect. This property of the drug is provided by its active element. Doctors report that amlodipine not only dilates the arterioles (peripheral), but also reduces the OPSS. In this case, the said ingredient does not cause tachycardia (reflex).
What is the result of using the drug "Amlodipine"? What helps this tool? Thanks to such a preparation, the human heart begins to consume much less energy and the need for myocardium in oxygen significantly decreases.
Kinetic features of the drug
The drug "Amlodipine" from the pressure (increased) is absorbed from the intestine very slowly, but in full. The peak concentration of its active component in the blood is reached after 8.5 hours. The binding of the drug to plasma proteins is approximately 98%.
The drug "Amlodipine", whose action is aimed at lowering the pressure, undergoes minimal metabolism. In this case, derivatives are formed that have little pharmacological activity. The drug is metabolized when passing through the liver.
The average half-life of amlodipine and its derivatives is 36 hours. With very high blood pressure, this time can be increased to two days, in elderly people - up to 66 hours, and with liver dysfunction - up to 58 hours.
A drug is produced in the form of metabolites through the intestine and kidneys.
The drug "Amlodipine": what helps?
In what cases can the medication be prescribed to the patient? Indications for taking this remedy are the following conditions:
- Stenocardia is stable;
- Vasoconstriction or vasospasm;
- Angina pectoris;
- Hypertension arterial (as a monotherapy and in combination with other medicines);
- Cardiomyopathy dilated non-ischemic.
In what other cases can the drug "Amlodipine" be recommended? What helps this medicine? It is often prescribed together with antianginal medications, including patients who are immune to treatment with beta-blockers or nitrates.
Prohibitions to take the drug
Now you know the purpose for which patients are prescribed "Amlodipine" tablets. The indications of this medication are listed above.
As for contraindications, the use of this medication is prohibited with arterial hypotension. In addition, it is not recommended to use at a minor age, as well as in the presence of hypersensitivity to its ingredients.
How should I take Amlodipine?
Analogues, the price of this medication is indicated below.
The agent is intended for oral administration. The dosage of this drug is calculated by the doctor, depending on the condition of the patient.
For patients with hypertension (arterial) and angina pectoris, the minimum dose of this medication per day is 5 mg. If required, then in the future this amount can be increased exactly twice, that is, to bring up to 10 mg per day.
In the therapy of dilated cardiomyopathy, this medication is recommended to take in a dose of 2.5 mg. If the drug is well tolerated, its quantity can be increased fourfold.
According to experts, exceeding recommended dosages of the drug (more than 10 mg per day) is highly discouraged, as this can lead to the development of undesirable effects.
Reception of "Amlodipine" together with beta-blockers, diuretics (thiazide) and ACE inhibitors does not require dosage adjustment.
How is the drug "Amlodipine" carried by patients? Side effects of this drug are practically absent. However, in some cases (for example, in case of non-compliance with dosages), it can still cause:
- Tachycardia, gingival hyperplasia, hyperemia, drowsiness;
- Arrhythmia, nausea, palpitation, headache, dyspnea;
- Abdominal pain, peripheral edema, fatigue;
- Arterial hypotension, rash, paresthesia, itching, dizziness.
It should also be noted that with prolonged use of the tablets in question, the patient may experience pain in the limbs.
Cases of drug overdose
Information on cases of overdose with this medication is not available today. Although doctors suggest that when taking a large amount of the drug in patients can manifest severe side effects.
Is it permitted to take Amlodipine medication together with other drugs? Instruction, reviews of experts argue that the hypotensive effect of this drug is enhanced if it is combined with calcium channel blockers. A similar result is expected when using funds intended for inhalation anesthesia and orlistat. By the way, such combinations can provoke even a hypertensive crisis.
Reduction of antihypertensive effect and sodium retention in the human body are observed with the use of tablets "Amlodimin" with estrogens and sympathomimetics.
The development of such symptoms of neurotoxicity as tinnitus, nausea, ataxia, vomiting and diarrhea is caused by the simultaneous administration of amlodipine and lithium carbonate.
The concurrent use of the drug in question and indomethacin, as well as other NSAIDs, leads to a reduction in the antihypertensive effect of the former.
Breastfeeding and pregnancy
The safety of the drug "Amlodipine" during pregnancy has not been studied. The same applies to the lactation period. In this regard, the drug in such provisions should be used only if the risk to the child is much less useful for the health of the mother.
General recommendations for taking the drug
The instruction, attached to the tablets, states that they should be taken with extreme caution in case of impaired liver and kidney function, as well as stenosis of the aortic aorta.
Adjustment of the dose of the drug, which was mentioned above, is not required for older persons.
Medication "Amlodipine" can be used to treat patients with a diagnosis such as dilated cardiomyopathy (non-ischemic), which is accompanied by heart failure (chronic).
Clinical studies on the use of the drug in question in pediatric practice have not been conducted.
Terms of sale and storage, the period of implementation
Keep this medication in a dark and dry place, where the air temperature does not exceed 25 degrees, and where little children can not access.
This remedy is released without a medical prescription. According to the instructions, the expiration date is 24 months. After this period, take the medicine is prohibited.
The cost of medicines in pharmacies and similar facilities
How much are the tablets "Amlodipine"? The price of this drug may be different, but in any case it is not very high. The drug in a dosage of 10 mg costs about 55 rubles, and in a dose of 5 mg - about 35 rubles.
As mentioned above, arterial hypertension is a fairly common disease. Therefore, every year, pharmaceutical companies produce more and more drugs designed to lower high blood pressure. By the way, there are many analogs to the means under consideration. Doctors say that antihypertensive properties are characteristic for the following medicines: Agen, Tenox, Akridipin, Stamlo M, Adipin, Stamlo, Amlo, Normodipin, Amlodipine Sandoz, Omelar Cardio, Vero Amlodipine, Norvasc, Amlodipine Teva, Cordy Cor, Amlodak, Norvadin, Amlovas, Corvadil, Amlodigamma, Cardilopin, Amlodipine Alkaloid, Karmagip, Amlodil, Calchek, Amlodipine Zentiva, Amlonorm, Amlodipine-Agio, Amlotop, Amlodipine Cardio, Amlosus, Amlodipharm, Amlodipine Bezilat, Amlong, Am Lockard-Sanovel ", and so on.
Reports of patients and doctors
With age, an increasing number of people are exposed to a disease such as hypertension. As is known, the following symptoms are typical for such a phenomenon: dizziness, excessive fatigue, headaches, weakness, darkening in the eyes, drowsiness and so on. According to experts, all these signs disappear within a few hours after using the tablet "Amlodipine" in a dosage of 5 or 10 mg.
Doctors report that the drug in question is one of the fastest and most effective means. In a short period of time, it stabilizes the patient's blood pressure, and also significantly improves his general condition.
As for consumers, among the merits of this tool, they note its convenient way of application and form. To reduce the increased pressure, the patient is required to take only one tablet. In this case, doctors warn that an overdose of this medicine can contribute to the emergence or increase of adverse reactions. In this regard, they do not recommend eating more than 10 mg of the drug per day.
It should also be noted that a large number of consumers are pleased with the low price of the said product, as well as its availability in all pharmacies and the ability to replace them with analogs.