"Zaldiar": instructions for use. Reviews, price, description of the preparation

Pain is considered one of the most unpleasant phenomena in a person's life. Most of the existing drugs are able to remove weak or moderate intensity pain. Opioid analgesics, which include the "Zaldiar" remedy, described in this article, helps to get rid of even severe pain caused by severe diseases.

Despite the fact that the drug is not narcotic, its leave in pharmacies is carried out only on prescription (Form 148). This is due to the fact that certain components included in its composition are experts in strong substances. The prices of this group of medicines can not be called affordable for a large number of consumers, which is also a definite obstacle to the wide distribution of the drug. But we will talk about this a little later, but first we will understand in the composition of tablets, the main properties of its active substances and much more.

Composition of tablets "Zaldiar"

What is special about Zaldiar? The composition is what plays the leading role in the effectiveness of any drug. In addition to the known and widely used paracetamol, which is present in 325 mg tablets, Zaldiar contains a substance known as tramadol hydrochloride (37.5 mg). If with paracetamol consumers are familiar almost from childhood, then tramadol is less well known in wide circles. In addition, sometimes it is considered a drug, although in fact it is not. Like all opioid analgesics of synthetic origin, tramadol has the ability to act in two ways, which allows it to be used to eliminate high and medium intensity pain. More about this will be told in the section on pharmacological properties.

In addition to the active ingredients, the preparation Zaldiar contains a set of auxiliary components: cellulose, starches, magnesium stearate, dyes and much more.

Description of the preparation, form of release

The drug is produced in the form of tablets coated with a film intestine-soluble coating. The form of the tablets is oblong, rounded, biconvex, on one side there is an inscription "т5", and on the other - the logo of the manufacturer "Grünental". The color of the shell is light yellow. At the break of the tablet, two layers are clearly visible: the outer yellow and the inner one are white or almost white in color.

Tablets "Zaldiar" are packed in blisters of 10 pieces, which are placed in cardboard boxes for 1, 2, 3 or 5 pieces together with instructions for use.

Pharmacokinetics and pharmacodynamics of the drug Zaldiar

The composition of the drug is immediately two active substances with analgesic effect. That is why the tablets "Zaldiar" instructions for use refer to combined drugs. The effect of eliminating the pain in this case spreads in several directions at once. That allows you to eliminate even severe pain.

Pharmacodynamics of paracetamol is to deactivate cyclooxygenase in the pain and temperature centers of the brain. In this case, this substance does not affect the peripheral tissues, namely their prostaglandinsynthetic functions. In addition, paracetamol does not affect the water-electrolyte balance of the body.

Tramadol acts on the pain centers somewhat differently: the substance and its metabolites have the ability to activate the so-called m-opiate receptors. It also activates non-opioid receptors through membrane hyperpolarization in spinal cord synapses and spinal neurons. Despite the similarity of the action of tramadol with narcotic substances, its effect is 6000 times weaker, for example, morphine.

Absorption of paracetamol and tramadol in the digestive tract occurs quickly enough. At the same time, complete absorption of paracetamol is much faster than tramadol. The cleavage of these active substances occurs mainly in the liver. They are excreted mainly through the urinary system (30% unchanged, at least 60% as metabolites).

Indications for use

The drug "Zaldiar" is recommended for use in cases of severe and moderate pain of various origins (vascular diseases, trauma, inflammation, etc.). In addition, it is advisable to use this drug before carrying out medical procedures (diagnostic and therapeutic) that can cause pain. To buy the drug "Zaldiar" without a doctor's prescription, as mentioned above, is not possible. That is why its use is only available when it is really needed.

Contraindications

Concerning the use of "Zaldiar" tablets, the instructions for use mention contraindications, which imply the impossibility of taking this medication, as well as its analogs for active substances. The first and most important contraindication is the individual intolerance of its constituent components, including excipients. The second contraindication is the age of the patient to 14 years. In addition, there is a fairly extensive list of diseases and conditions in which taking the drug is not possible in connection with the risk of developing a variety of complications.

So, we will consider, in what cases are contraindicated tablets "Zaldiar" (analogues for active substances should also not be used in the cases listed below):

• Epileptic seizures, not controlled by the intake of special drugs;
• Severe diseases of the kidneys and liver, in particular liver and kidney failure;
• State after the abolition of narcotic substances, or so-called withdrawal syndrome;
• Alcohol or drug intoxication (including drugs that depress the central nervous system, hypnotics, analgesics and other medications).

The above states are mandatory. Next, we list the situations in which the use of Zaldiar requires caution and constant monitoring of the patient's condition:

• A shock condition caused by trauma or in other cases;
• Craniocerebral trauma of varying severity;
• Increased intracranial pressure (hypertension);
• Epilepsy, controlled by the intake of medications;
• Disturbances of respiratory function;
• Confusion or confusion of consciousness of different origins;
• Viral diseases of the liver (hepatitis);
• Bile duct disease;
• Alcoholism with or without liver damage;
• Dependence on narcotic drugs;
• Hyperbilirubinemia (benign);
• Pain in the epigastric region of unknown origin.

In addition, Zaldiar recommends using the instruction for use with caution to persons over 75 years of age, and also to those who, in addition to this drug, are prescribed psychotropic and other pain killers with so-called central action (including local anesthesia ).

In order to avoid an unjustified risk to the health of the patient, the physician must conduct all necessary studies before the prescription of the drug, with the help of which it is possible to identify the above-mentioned diseases.

How to take Zal'diar: instructions

The drug "Zaldiar" is taken exclusively under the supervision of a doctor. The dosage and the regimen are determined by the specialist, based on the patient's condition, the degree of pain. According to the recommendations of doctors, you need to take the pills whole, not crushing and not chewing. The amount of water that the medication is consumed must be sufficient to allow it to enter the stomach unhindered.

The initial dose for adult patients (over 14 years) is 1-2 tablets, depending on the recommendations of a specialist. In a day is not recommended to use more than 8 tablets "Zaldiara". Between the techniques you need to observe the time interval of 6 hours. If the next appointment was missed for some reason, there is no need to use the present and previous doses of the drug.

For elderly patients (over 75 years of age), the usual doses of the drug can be used, but the fact that the removal of the components of the drug and metabolites in such people is slower than in other age groups. In this regard, it is recommended to increase the interval between tablets up to 10-12 hours.

Renal and hepatic insufficiency also requires correction of the regimen of taking and dosing the drug Zaldiar. It should be noted that during the hemodialysis, the active substance of the tramadol tablets is practically not removed from the body. Therefore, patients with impaired renal function should not take a second dose of the medication after this procedure, as this can lead to an overdose. The same recommendations can be addressed to patients with severe impairment of liver function. In this case, the danger of complications does not come from tramadol, but from paracetamol. The risk of complications is significantly increased in individuals whose liver has undergone changes due to alcohol exposure.

Interaction of the drug with other drugs

The drug "Zaldiar", which will be described further on, is able to interact with many medications. Not always this combination has a positive effect on the patient's body. That's why experts recommend that those who take these pills report on the drug when they prescribe other drugs.

It is important to remember that the joint taking of Zal'diar medication, the price of which will be announced below, with other opioid preparations, entails the risk of withdrawal syndrome due to competition of active substances with respect to pain receptors. If you need to take this drug, other drugs with similar properties should be discarded.

Medications that depress the central nervous system, which include tranquilizers and hypnotic drugs, increase the side effects characteristic of Zaldiar tablets. The same applies to alcohol-containing products.

A number of drugs, the main property of which is the induction of microsomal oxidation, as well as tricyclic antidepressants, barbiturates and ethanol, reduce the effect of active components of Zaldiere tablets on painful centers, as a result of which their analgesic effect decreases. The duration of action of the drug also decreases.

Joint use of barbiturates with the drug reduces the effectiveness of paracetamol, and alcohol together with it can cause the development of pancreatitis in acute form. Nonsteroidal anti-inflammatory drugs are also not recommended for taking with Zaldiar tablets because of their specific interaction with paracetamol. The fact is that at the same time, the risk of developing renal failure and necrosis of the papillary kidney structures is significantly increased. In particularly severe cases, the patient can develop kidney or bladder cancer.

With prolonged use of the drug Zaldiar, even small anti-coagulant anti-coagulant effects on the body increase, which increases the risk of bleeding.

Adverse Reactions

The tablets "Zaldiar" have many side effects that affect almost all organs and systems. Often patients from the first day of taking the medication begin to worry about dizziness, partial loss of memory, cramps or tremor. Also among the undesirable reactions of the body to taking the drug are such phenomena as drowsiness or insomnia, nausea, increased gas formation, digestive disorders and heart rhythm. In addition to the above, patients may experience irregular menstrual cycles, delay or lack of urination, dyspnoea, aplastic anemia.

With prolonged treatment with Zaldiar, drug dependence or withdrawal can develop after a sharp refusal to take tablets. To avoid this, do not take this medication for longer than recommended by the instructions for use, and the drug should be withdrawn by a gradual dose reduction.

special instructions

Prolonged uncontrolled intake of drugs containing tramadol can lead to drug dependence, expressed in nervousness, psychomotor activity and phobias. In connection with this, during the period of treatment with Zal'diar, the price of which is high enough, it is necessary to strictly follow the recommended duration of its reception. Patients who previously had this dependence should take the medicine under the supervision of a doctor.

Driving vehicles and managing complex mechanisms during drug treatment is best to cease.

Analogues of the preparation "Zaldiar": prices and reviews

So, proceeding from the aforesaid, it is possible to draw a conclusion, that the main thing, than it is necessary to be guided at reception of a preparation "Zaldiar" - the instruction. The price of tablets in comparison with other potent drugs does not seem very high and is about 800 rubles per package. There are few analogues of the drug: the content of the two active components can be distinguished except that tablets "Forsodol", the cost of which is much higher. Undoubtedly, the prices for medicines from the group of opioid analgesics can not be low, and the "Zaldiar" remedy is the most affordable among such drugs.

According to experts, this medication helps to cope with the pain syndrome even in very difficult cases. However, they indicate that prolonged or uncontrolled treatment with the drug can lead to unexpected and extremely negative results. Patients who used this medication also remained satisfied with its effectiveness. But at the same time they noted that his cancellation should be gradual. Since in more than 70% of cases they had symptoms of a so-called withdrawal syndrome.