"Remeron": instruction manual, doctor's comments. Drug analogues

In our difficult times, the number of individuals suffering from depressive disorders increases every year. With this state of affairs, modern antidepressant drugs take on special urgency. One of the best similar remedies is "Remeron", the instruction on application to which is given in this article. Readers interested in this topic will be interested to know about the composition of the drug, its properties, the method of application and, of course, about how doctors respond about this medication.

Composition of the preparation and form of release

The drug is issued in tablets of a reddish-brown color, biconvex form, each of which contains 15, 30 or 45 grams of active substance-mirtazapine. On one side of the tablets there is the marking Organon - this is the name of the Netherlands manufacturer of this drug, on the other side you can see the code TZ / 5. All of the above applies only to the antidepressant, manufactured under the trademark "Remeron". Analogues of the medicine, the list of which can be read in our article, may have a composition almost identical to "Remeron", but their name and appearance will be different.

New generation antidepressant

Why do psychiatrists today, if patients address them about depression, panic attacks, etc., often appoint them exactly "Remeron"? The instructions for use describe in some detail the mechanism of its action, but unfortunately, it does not indicate that it is an antidepressant of a new generation, in the development of which many factors were taken into account that made it possible to make the drug as efficient as possible while also reducing side effects.

In a scientific article devoted to mirtazapine, the main active ingredient in Remeron, the psychotherapist, a member of the Institute of Gerontology of Kyiv, Burchinsky SG writes that this tool is characterized by the following important characteristics:

• The clinical effect after the beginning of taking the medicine comes very quickly (almost in the first week of use);
• Pronounced anxiolytic and thymoanaleptic effect;
• Sedative effect and normalization of sleep.

Effect of the drug on the structure of sleep

"Remeron" is able to effectively affect depressive symptoms that are difficult to correct by other antidepressants (cyclothymic disorders, psychomotor retardation, anhedonia). Doctors say that mirtazapine is extremely effective both in the treatment of acute depressive episodes, and in supportive therapy. His influence on the normalization of sleep is especially emphasized.

It is known that with depressive disorders sleep disturbance is one of the typical symptoms of this pathology and is observed in almost 90% of patients. These disorders consist of disorders during sleep and awakening, as well as disorganization of the overall structure of sleep. Solving this problem is a very important component in helping those suffering from depression. The majority of such people who have turned to a medical institution, there is a distinct relationship between the severity of insomnia and the severity of affective symptoms.

In this case, sleep disorders can seriously complicate the course of the pathological process, and also precede the disease and accompany it. Subsequently, they can increase the risk of relapse. Proceeding from the above, it can be concluded that therapeutic measures taken to normalize sleep in patients with depression should be not so much symptomatic as pathogenetic. "Remeron," based on mirtazapine, is one of the rare antidepressants that can successfully correct insomnia in patients with depression.

Application in geriatric practice

According to the doctors' observations, "Remeron" is very well tolerated by people of elderly and senile age, while it is very effective and beneficial for this category of patients. This is an undoubted plus of the drug, since many of the symptoms accompanying depression (anhedonia, anxiety, sleep disorders, etc.), especially often persecute people in old age. Given the fact that in this age group, the use of TAD (tricyclic antidepressants) is not recommended, in gerontopsychiatry, "Remeron" is used in the treatment of virtually all forms of depressive pathologies.

Correction of sexual disorders

With such sexual disorders as anorgasmia, accelerated ejaculation, decreased libido , etc., which often accompany the clinical manifestations of depression on the one hand, and on the other - often arise as complications in the treatment of SSRIs (selective serotonin reuptake inhibitors), " Remeron "and its analogues serve doctors a great help. Preparations based on mirtazapine perfectly correct a wide variety of sexual dysfunctions in patients with depression. At the same time, they not only increase the effectiveness of treatment, but also act as preventive agents against the development of sexual disorders.

"Remeron": instructions for use

The insert, attached to the drug, says that you should take the medicine once a day just before bedtime. The daily standard dose may vary between 15-45 mg, with no special adjustment of the amount of the drug for the elderly. It is very important not to allow an overdose of the medicine "Remeron". The patient's feedback is confirmed in the instructions: overdose causes not an improvement in the condition, but a retardation and drowsiness. During treatment it is important to refrain from drinking alcohol-containing beverages.

An increase in sedation can be triggered by the simultaneous administration of the drug with benzodiazepines. It is not recommended to drink tablets "Remeron" - 30, 15 and 45 grams with MAO inhibitors, and after the abolition of the last for fourteen days. Therapeutic therapy with the help of "Remeron" instruction recommends to continue and after the disappearance of painful symptoms; Do this for six months. The drug should be withdrawn gradually. Important: this drug is sold at pharmacy points only on the prescription of a doctor!

Indications for use

When do doctors recommend taking "Remeron"? Instruction for use calls as indications the following disease states caused by depression:

• Psychomotor retardation;
• Anhedonia;
• Loss of interest in life;
• insomnia;
• Suicidal thoughts;
• anxiety;
• Pain syndromes;
• Mood lability;
• Early awakening;
• Weight loss, etc.

Contraindications

"Remeron" is a drug that can not be used by people who are highly sensitive to its main active ingredient, the substance mirtazapine, as well as to any of the auxiliary components of the drug. The following contraindications are the period of pregnancy, lactation, renal or hepatic insufficiency. There are also relative contraindications:

• Hypertrophy of the prostate;
• diabetes;
• Angle-closure glaucoma;
• Atrial tachyarrhythmia;
• Arterial hypotension ;
• Angina pectoris;
• Organic brain damage (headache);
• The tendency to abuse of psychoactive drugs.

Drug analogues

If for some reason it is impossible to buy "Remeron" in the pharmacy, the analogs can replace it. Here are their names:

• "Mirzaten Ku-tab".
• "Kaliksta".
• "Mirtalan".
• "Mirtazonal".
• "Esprital".
• "Noxibel."
• Mirtazapine Hexal.

"Remeron": reviews of doctors

Specialists highly appreciate the pronounced therapeutic properties of this antidepressant of the new generation. Before the medicine became part of everyday medical practice, the effects of mirtazapine were studied very carefully. So, there is an article by Maria Morozova, an employee of the Moscow Scientific Center for Mental Health of the RAMS, where she tells about the results of such studies.

In the trials, 63 patients with moderate and severe depression participated, with various variants of affective disorders identified ; 12 psychiatric hospitals of different cities of Russia were involved. As part of the experiment, doctors were instructed to use only mirtazapine for the treatment of all patients hospitalized with depression. The total duration of drug therapy for each patient was 42 days. During this time the drug showed itself very well.

Also, there are results of studies of complex treatment of patients with alcohol dependence, in which "Remeron" was used. The doctors' comments on the effect of the drug were also positive. Patients with abstinence syndrome managed to quickly stop panic attacks, irritability, insomnia, normalize the pulse and blood pressure. Later in the remission period, the drug contributed to a decrease in craving for alcohol and stabilization of the mental state of patients.

Side effects

As you can see from the previous chapter, doctors highly value the antidepressant "Remeron". Their patients' responses are far from such unanimity. In some people, taking the drug can cause unwanted side effects. Here is a list of possible side effects listed in the instructions.

1. The digestive system:

• nausea;
• thirst;
• Constipation;
• Increased energy of hepatic transaminases;
• Increased appetite;
• Accumulation of body weight;
• Vomiting;
• Pain in the abdomen, dryness in the oral cavity.

2. From the side of the nervous system:

• Hypokinesia;
• drowsiness;
• tremor;
• Retardation;
• Convulsions;
• Change in mentality and mood;
• Hyperkinesis;
• Myoclonus;
• agitation;
• anxiety;
• Depersonalization;
• apathy;
• mania;
• Hallucinations;
• dizziness;
• Emotional instability;
• Vertigo;
• hostility;
• Epileptic seizures;
• Hyperesthesia.

3. Cardiovascular system:

• Hypotension orthostatic;
• Lowering blood pressure.

4. Genitourinary system:

• Dysmenorrhea;
• Lowering the potency.

5. The system of hematopoiesis:

• Agranulocytosis;
• Aplastic anemia;
• Granulocytopenia;
• Thrombocytopenia;
• Neutropenia;
• Eosinophilia.

6. Allergic reactions: urticaria.

7. Other side effects:

• Edematous syndrome;
• Influenza-like syndrome;
• myalgia;
• suffocation;
• Dysuria;
• backache;
• Withdrawal syndrome.

Despite all the above, among doctors "Remeron is considered one of the safest drugs in the category of drugs for the treatment of depression.For example, unlike tricyclic antidepressants, it does not cause a " serotonin syndrome, "is virtually devoid of cardiotoxicity and has little anticholinergic properties such as indigestion And dry mouth.Some side effects (drowsiness, dizziness, increased sedation, increased appetite, etc.) are noted only at the very beginning of therapy, and subsequently pass without a food.

Overdose of the drug "Remeron"

The instruction indicates that the following symptoms can occur when an overdose occurs:

• Retardation;
• disorientation;
• drowsiness;
• tachycardia.

In such cases, treatment is carried out with activated charcoal, gastric lavage, oxygenation and ventilation, as well as the use of symptomatic therapy.

special instructions

Antidepressant "Remeron" can cause in patients with schizophrenia increased psychotic symptoms. During treatment of the depressive phase of affective bipolar psychosis, an affect inversion with the appearance of mania is possible. However, if there are suicidal tendencies, it is recommended that the patient be given a limited amount of medication. If the patient is a woman of reproductive age, the appointment of tablets is carried out only under the conditions of using her reliable contraceptives.

Abrupt withdrawal of the drug, following a prolonged use, can trigger the appearance of nausea, headaches, general deterioration of well-being. Reception "Remeron" should be discontinued if there are any symptoms of any infectious diseases, jaundice or changes in blood. For the period of taking the drug, patients are required to be more cautious when driving a car, as well as when engaging in other potentially risky activities and activities that require the speed of psychomotor reactions and increased attention fixing.

Conclusion

From all that has been said in the article, we can conclude that "Remeron" is a pill that can help even with severe depressive mental disorders. At the same time, they are far from harmless, and they must be used only on the instructions of the doctor, and also under his close supervision. Many people for years suffer from depression, are treated independently by various medications and do not get the desired result. Meanwhile, it is enough to visit an experienced specialist to get a prescription for the purchase of a really effective drug, for example, such as the medicine "Remeron". Do not delay visit to the doctor. Be healthy and happy!