"Meloksikam-Prana": instructions for use, feedback

In this article we will talk about the drug "Meloksikam-Prana". Instructions for use, reviews and recommendations of medical professionals - something that will interest us in the first place. In addition, we will detail the indications, contraindications, side effects of the drug. And also consider the composition and pharmacological properties.

General information

Refers to a large group of anti-inflammatory non-steroidal medicines preparation "Meloksikam-Prana". Instructions for use (tablets) contains recommendations for proper storage of the product. So, the drug should be kept in a dry, dark place, the temperature limits of which are in the range from 0 to 25 ° C. Under such conditions, the drug will be suitable for use for 3 years.

Tablets of the drug are available in 7.5 or 15 mg. They can be packed in blisters of 10 tablets or in a polymer jar (from 50 to 100 pieces). Blisters or jars are packed in cardboard boxes along with instructions.

"Meloksikam-Prana" is released in pharmacies without a prescription.

Composition

"Meloksikam-Prana" (instruction for use confirms this) has in its composition an active substance called meloxicam. Depending on the form of release, its amount in the tablet can be as much as 15 mg and 7.5 mg.

In addition, the preparation contains the following auxiliary ingredients:

• Microcrystalline cellulose;
• Colloidal silicon dioxide ;
• Magnesium stearate;
• corn starch;
• Lactose monohydrate;
• Sodium croscarmellose.

Pharmacology

"Meloksikam-Prana (the instruction contains this information) has analgesic, antipyretic and anti-inflammatory effects. The effectiveness of the drug is provided by inhibiting the activity of COX-2 (cyclooxygenase), which is involved in the biosynthesis of prostaglandins in the place where inflammation began. Much less drug affects COX-1, which is involved in the synthesis of prostaglandins, protecting the mucosa of the gastrointestinal tract and involved in the regulation of blood supply to the kidneys.

"Meloksikam-Prana" is perfectly absorbed by the digestive tract. In addition, eating does not in the least affect this process.

The drug is sufficiently accumulated in the body and begins to act actively during a 3-5-day period. The level of meloxicam in plasma does not change even after taking the drug for more than 1 year.

The drug is completely metabolized by the liver, resulting in the formation of four pharmacologically inactive metabolites. The main one is carboxymelloxicam (60%). "Meloksikam-Prana" is excreted from the body with urine and feces. In elderly patients, the time taken to withdraw the drug is increased.

Indications

In what cases can doctors appoint Meloksikam-Prana? Indications for use, compiled by the manufacturer, are the following diseases:

• Arthritis rheumatoid;
• Bechterew's disease (ankylosing spondylitis);
• Osteoarthritis.

However, the drug is prescribed only for symptomatic therapy, since it reduces pain and inflammation, but does not eliminate the causes of the disease and does not prevent their progression.

"Meloksikam-Prana": instructions for use

Tablets of the drug are available in two dosages - 15 mg of active substance and 7.5 mg, so the doctor, prescribing the prescription, will be guided by the form of release.

Patients suffering from rheumatoid arthritis are recommended to take 15 mg tablets. If the drug has a high therapeutic effect, then the dosage is usually recommended to be reduced to 7.5 mg.

People with a diagnosis of osteoarthritis are given a tablet with 7.5 mg of active substance. And only in the absence of the necessary effect, the dosage is increased to 15 mg.

Those who are sick with ankylosing spondylitis, prescribed 15 mg per day.

In all the above situations, "Meloksikam-Prana" is taken 1 tablet a day with food. Increase dosage without consultation is strictly prohibited.

For patients who are diagnosed with impaired renal function and side effects may occur, the daily dose of the drug should not exceed 7.5 mg.

Application Features

It is necessary to observe precautions when prescribing and using the drug "Meloksikam-Prana". Instructions for use highlight patients who have been diagnosed with duodenal ulcers or stomach ulcers and who underwent anticoagulant therapy. This is due to the fact that in such patients the risk of developing ulcerative-erosive lesions of the gastrointestinal tract increases, therefore, Meloksikam-Prana should be taken with caution.

Also, the drug is prescribed with caution to elderly patients, patients with chronic heart failure, liver cirrhosis, hypovolemia.

It is not recommended for people taking a medicine to engage in work related to a variety of hazards and requiring increased attention, as the drug may cause dizziness, headaches and drowsiness.

Side effects

Has "Meloksikam-Prana" side effects.

In relation to the gastrointestinal tract, often (1% of cases) there are:

• dyspepsia;
• Vomiting;
• nausea;
• Constipation;
• Abdominal pain ;
• diarrhea;
• flatulence.

Rarely (from 0.01 to 0.1% of cases):

• Eructation;
• Hyperbilirubinemia;
• Esophagitis;
• Bleeding GIT;
• Gastroduodenal ulcer;
• stomatitis.

Very rarely (in 0.01% of cases):

• colitis;
• gastritis;
• Perforation of the gastrointestinal tract;
• hepatitis.

In the work of the cardiovascular system, the following changes can occur:

• Peripheral edema (often);
• Tachycardia (rarely);
• Sensation of "tides" (rarely);
• High blood pressure.

On the part of the respiratory tract in rare cases, bronchial asthma can be observed.

Side effects associated with the central nervous system:

• Dizziness (often);
• Headaches (often);
• Tinnitus (rarely);
• Drowsiness (rarely);
• Vertego (rarely);
• Confusion (very rarely);
• Disorientation (very rarely);
• Emotional lability (very rarely).

The following changes may occur in the urinary system:

• Elevated serum urea concentration and hypercreatininaemia (rarely);
• Kidney failure (very rare);

Dermatological side effects:

• skin rash;
• Itching;
• Urticaria (rarely);
• Bullous eruptions (very rarely);
• Increased photosensitivity (very rarely);
• Epidermal necrolysis (very rarely).

Reactions from the hematopoietic system can be as follows:

• Anemia (often);
• Thrombocytopenia (rarely);
• Leukopenia (rarely).

The drug may cause allergic reactions. If the first signs occur, it is necessary to take an antihistamine drug, stop taking the medication and consult a doctor.

Contraindications

The preparation "Meloksikam-Prana" (instructions for use contains clear instructions on this matter) is not assigned in the following cases:

• Hypersensitivity;
• Complete or partial combination of recurrent nasal polyposis, bronchial asthma, intolerance to acetylsalicylic acid;
• Peptic ulcer disease of the duodenum and stomach (exacerbation phase);
• Severe renal failure;
• Various bleeding;
• Inflammatory bowel disease;
• Various kidney and liver diseases (progressing);
• Severe heart failure;
• Lactose intolerance or deficiency;
• bronchial asthma.

Also, the drug is prohibited from prescribing to children up to 12 children, pregnant and lactating women.

Interaction with other drugs

It is possible to note the following features when interacting with other medications of the drug "Meloxicam-Prana" (the instruction for use draws special attention to this):

• Application together with other NSAIDs may increase the risk of opening gastrointestinal bleeding and the appearance of erosive-ulcerative abnormalities;
• The use of a drug with antihypertensive drugs may cause a decrease in the effectiveness of the latter;
• While concomitant administration with lithium-containing drugs may increase the toxic effect of the metal and the development of lithium cumulation (it is usually recommended to monitor the concentration of lithium in the blood throughout the therapy);
• Prescribing simultaneously with methotrexate may lead to an increased risk of leukopenia and anemia, therefore it is recommended that a general blood test be performed periodically;
• Simultaneous application with cyclosporine and diuretics leads to the possibility of the occurrence of renal failure;
• With the simultaneous reception of "Meloxicam-Prana" with intrauterine contraceptive drugs, the effectiveness of the latter decreases;
• Simultaneous use with thrombolytic drugs and anticoagulants (warfarin, heparin) significantly increases the risk of various bleeding, so it is necessary during the therapy to monitor the blood clotting level in the patient;
• When used simultaneously with colestyramine, the amount of meloxicam produced through the gastrointestinal tract is increased.

Overdose

We examined in detail the instructions for the use of the drug "Meloksikam-Prana", from which it helps, we found out when it should not be taken-they were also indicated. Now let's list the symptoms of an overdose:

• nausea;
• Impaired consciousness;
• Bleeding GIT;
• Pain in epigastrium;
• Acute renal or hepatic insufficiency;
• Asystole;
• Respiratory arrest.

If any of the above symptoms occur, it is necessary to immediately rinse the stomach and take activated charcoal. If necessary, symptomatic treatment is performed. There is no specially developed antidote.

«Meloksikam-Prana: Feedbacks

Tablets have a lot of positive feedback from patients. So, high efficiency of the drug is noted and pleasantly pleases the speed of action. Important is the availability of the drug in pharmacy chains. Despite the abundance and variety of side effects, they are rare.

However, there are a number of negative reviews about the drug. Basically, they are associated with disruption of work and exacerbation of various ailments of the gastrointestinal tract. But there are similar problems for the most part in patients even before taking the remedy.

Thus, "Meloksikam-Prana", reviews of which mostly only laudatory, proved to be a reliable and effective drug, which, however, is not recommended for people with various gastrointestinal diseases, especially acute ones.

It is necessary to pay attention to the fact that the drug is dispensed without a prescription, but this does not mean that you do not need to seek medical advice before using it. Also, it is not worthwhile replacing the prescribed drug with Meloxicam, which can be its cheaper analogue. Be healthy!