"Tinidazole": from what heals, instruction, contraindications

What is a drug "Tinidazole"? What does this medicine treat? You can find answers to these questions in this article. Also, it will provide information on whether there are analogues for the drug in question, what reviews about it leave patients and how much it costs in pharmacy chains.

Form of preparation, its packaging, composition

What form is inherent in the drug "Tinidazole"? Reviews say that this drug is produced in the form of tablets, which are covered with a special coating.

The main ingredient of this medication is tinidazole. It also contains additional elements that are presented in the form of alginic acid, microcrystalline cellulose, magnesium stearate, sodium lauryl sulfate and starch.

With regard to the coating of tablets, it consists of titanium dioxide, propylene glycol and hydroxypropylmethylcellulose.

The drug "Tinidazole", the instruction of which is contained in a cardboard box, is packaged in blisters of 4 tablets.

Basic properties

What is Tinidazole? What does this remedy for? According to the instructions, this drug belongs to antiprotozoal medicines, which show pronounced antibacterial properties.

The principle of action of this drug is based on DNA damage and inhibition of the process of propagation of pathogens. It is particularly effective against such organisms as Entamoeba histolytica, Lamblia intestinalis and Trichomonas vaginalis.

It should also be noted that the agent in question has a bactericidal action against anaerobic bacteria.

Kinetic parameters

The drug "Tinidazole", the price of which is presented at the end of the article, has a high degree of absorption. Its bioavailability is 100%.

The association of the drug with plasma proteins reaches 12%. The peak concentration of tinidazole in the blood after ingestion is noted after two hours and is approximately 40-51 μg / ml. After another day it is about 11-19 μg / ml, and after 72 hours - 1 μg / ml.

This means penetrates the barrier of the placental and GEB. It is also excreted with the mother's milk within 72 hours after ingestion.

Metabolism of the drug occurs in the liver. In this case, pharmacologically active hydroxylated derivatives are formed, which suppress the growth of anaerobic bacteria and enhance the action of tinidazole.

The half-life of the drug in question is 12-14 hours. Approximately 50% of the drug is excreted together with bile. Through the kidneys this remedy is displayed in an amount of 12% (in the form of derivatives) and 25% (unchanged).

Medication "Tinidazole": from what heals?

Indications for this drug are the following:

• Trichomoniasis;
• Prevention of anaerobic infections (postoperative);
• Giardiasis;
• Eradication Helicobacter pylori (in combination with antibiotics or bismuth preparations) ;
• Amebiasis (including hepatic form);
• Aerobic-anaerobic infections mixed (in combination with antibiotic agents);
• Infections that are caused by anaerobic bacteria.

Prohibitions to receive funds

Now you know what the medicine "Tinidazole" is. From what this medicine treats, we also told above.

According to the instruction, the medication in question also has contraindications. These include the following states:

• Violations in the process of hematopoiesis;
• Organic diseases of the central nervous system;
• The first trimester of pregnancy;
• breast-feeding;
• Hypersensitivity to tinidazole and other derivatives of 5-nitroimidazole.

The drug "Tinidazole": instructions for use

The tablets considered are intended only for oral administration. Usually their dosage is calculated on an individual basis, depending on the nature of the disease and the patient's tolerance of the drug.

For adults this medication is prescribed in a dose of 1.5-2 g once a day. As for toddlers (only not for the prevention of anaerobic postoperative infections), they are recommended to use 50-75 mg / kg once a day.

The duration of treatment with this remedy is determined by the doctor and can be about 2-10 days.

Side effects

The drug "Tinidazol" from fungus and other infections can cause the following negative effects:

• CNS and PNS: dizziness, dysarthria, headaches, excessive fatigue, convulsions, impaired coordination of movements, peripheral neuropathy, weakness.
• The digestive tract: diarrhea, anorexia, dryness of the oral mucosa, nausea, metallic taste in the mouth, vomiting.
• Allergies: urticaria, skin rash, itching, angioedema edema.
• Others: transient leukopenia.

Drug Interactions

Can I take Tinidazole with other medications? The reviews state that when a given drug and ethanol are taken together, a disulfiram-like effect may develop.

Breastfeeding and pregnancy

The drug "Tinidazole" is contraindicated for admission in the first trimester of pregnancy. The use of medication in the second and third trimesters is possible only if the prospective benefit for the future parturient exceeds the risk for the baby.

If this drug should be taken during breastfeeding, then it is necessary to resolve the issue of cessation of lactation. As is known, tinidazole is determined in the mother's milk within 72 hours after its administration.

Special Recommendations

When treating a disease such as trichomoniasis, it is necessary to conduct simultaneous treatment of both partners.

In the process of taking the drug should refrain from drinking alcoholic beverages.

If there are side effects from the central nervous system, the medication is canceled.

When you take tinidazole, urine can turn a dark color.

If the patient's treatment lasts more than 6 days, then it is necessary to carry out constant monitoring of the blood picture.

For the prevention of anaerobic infections (postoperative), dosage for children under 12 years is not established.

During treatment, the drug should be avoided from hazardous activities.

Price, analogues, consumer reviews

How much are tablets "Tinidazole"? The price of this medicine is about 30 rubles. For modern consumers, this cost is quite acceptable.

What can replace the drug "Tinidazole"? Analogs of this tool will be listed right now: Tiniba, Fazizhin, Vero-Tinidazol and Tinidazol-Akri.

Reviews about this medicine are mostly positive. Patients claim that this drug fights well against giardiasis and trichomoniasis. However, some consumers report that "Tinidazole" very often causes nausea, vomiting and dizziness.