Every year an increasing number of patients come to doctors complaining of high blood pressure. The reasons for the development of hypertension are many, so treatment should be selected individually for each person. The pharmacy can offer a huge number of medicines that help keep blood pressure values within normal limits. But the choice should be made only after consulting a specialist. In our article we will get acquainted with one of these medicines, we will consider what the drug "Kordaflex" is. Instructions for use, analogs, reviews are presented to your attention in the article.
Pharmacological action of "Kordaflex"
This drug is well known to patients suffering from hypertension. It is included in the group of antihypertensive drugs. The main active substance is nifedipine, it is capable of blocking calcium channels. After its administration, the transmembrane intake of calcium normalizes, which is disturbed by hypertension.
The drug has the following effect:
- Expands coronary vessels.
- Reduces the tone of blood vessels.
- Reduces the need for cardiac muscle in oxygen.
- Provides good nutrition to the ischemic areas of the heart.
- Reduces overall resistance.
After entering the body, the drug is well absorbed into the bloodstream, bioavailability is about 70%. The drug "Cordaflex" has a prolonged action, the maximum concentration is reached after 50-60 minutes and is maintained for 6 hours.
The active substance of the drug is able to penetrate in a small amount through the blood-brain barrier, the placenta and enter the breast milk.
To whom is shown the reception of "Cordaflex"
Any analogue of "Cordaflex", like the drug itself, is usually assigned under the following conditions:
- Increased blood pressure, which is observed for a long time.
- Hypertensive crisis.
- Cardiac ischemia.
- Angina pectoris.
As can be seen from the list of diseases, "Cordaflex" indications for use are limited and assigned for conditions associated with a risk of increased blood pressure. Do not self-prescribe this drug, because it has its own contraindications. This should be handled only by a competent specialist.
It is not always possible to take " Cordaflex" under high pressure. Its use is prohibited in the following states:
- Myocardial infarction.
- Cardiogenic shock.
- Low blood pressure.
- Aortic or mitral stenosis.
- Heart failure in the severe stage.
- The first trimester of pregnancy.
- Age to 18 years.
- High susceptibility to the components of the drug.
Choosing the drug "Cordaflex", the indications for use should be studied, but also on contraindications should also pay attention.
Undesirable manifestations during Kordaflex therapy
When taking any medicines there is a risk of side effects. "Cordaflex" is not an exception in this respect, although they are very rare. But it must be borne in mind that the following side effects are possible:
- From the cardiovascular system, it is possible to have severe arterial hypotension, an increase in heart rate, there may be swelling, an increase in angina attacks, syncope, and an increase in heart failure.
- The nervous system can react with sleep disorders, headache and dizziness, mood swings.
- Some patients may experience vomiting and nausea, dry mouth, bloating.
- A blood test can show leukopenia, anemia, or thrombocytopenia.
- Urination becomes more frequent, kidney function decreases, which is especially undesirable for those patients who suffer from kidney diseases.
- Some have allergic reactions in the form of skin itching, urticaria.
- Raise body temperature.
- Fluctuations in body weight, a person can either gain weight, or lose weight.
- Pain in the muscles and joints.
- General weakness.
With pronounced side effects, which do not go away after a few days of therapy, you should definitely consult a doctor. He will pick up an analog of the "Cordaflex", which will be better tolerated. This should not be done on your own.
Scheme of drug therapy
It is important to remember that only a doctor can prescribe this medication. "Cordaflex" indications for use is limited, but the therapy scheme will not be the same in all patients. Dosage is always prescribed individually, it will depend on the severity of the disease, the general condition of the body.
The drug is taken orally, the tablets should be consumed before meals and washed down with water.
The initial phase of therapy usually begins with taking 1 tablet three times a day. The daily maximum dosage should not exceed 40 mg. The drug "Kordaflex" is also available in the form of long-acting tablets, which must be taken 2 times a day, the interval between doses should be 12 hours.
The duration of therapy is determined by the doctor, but it should be borne in mind that the withdrawal of the medicine should occur gradually. If the side effects of " Cordaflex" are, the analogs of the drug can replace it, but the dosage and treatment regimen is determined by the doctor.
Symptoms of overdose
If you do not follow the doctor's recommendations for taking the drug and in the hope of a speedy recovery, take the medicine at a higher dosage, that is, the risk of the following consequences:
- A sharp drop in blood pressure.
- Pain similar to manifestation of angina pectoris.
- Loss of consciousness.
- In severe situations, metabolic alkalosis, cardiogenic shock with pulmonary edema.
- Impaired consciousness, risk of coma.
Any analogue of "Kordaflex" can also give such manifestations, if you take it at a higher dosage than prescribed by a doctor.
Interaction with other drugs
If the patient takes alcohol-containing medications, then it is not recommended to appoint "Cordaflex" at the same time. If you administer the medication together with Methyldopa, Clonidine, Prazozin, then orthostatic hypotension may develop .
Simultaneous therapy with cimetidine, ranitidine and tricyclic antidepressants will enhance the antihypertensive effect of Kordaflex.
If "Cordaflex" is combined with "Theophylline" and "Digoxin", then it is necessary to control the content of the latter in blood plasma.
Calcium, Rifampicin and Phenitonin reduce the effectiveness of Kordaflex, so it is better not to take them together. "Cordaflex" reduces the rate of excretion of "Vincristine", which can cause an increase in the manifestation of side effects, so you need to adjust the dosage.
Simultaneous reception of "Erythromycin", grapefruit juice and azole antimicrobial agents slows the metabolism of nifedipine, which must also be taken into account.
If "Cordaflex" is prescribed, the indications are important, but the doctor must be informed what medicines are being taken at the time. Then you can choose the appropriate dosage or replace the drug.
Use of the drug during pregnancy
It has already been noted that taking "Kordafleks" in the first three months of pregnancy is strongly discouraged. This is based on the fact that the active substance of the drug is able to penetrate the placental barrier. Special studies on the influence of nifedipine on the developing fetus were not conducted, so it is better not to risk the health of the baby's future.
At later dates, the use of the drug is indicated only when other drugs can not normalize blood pressure.
Given that nifedipine can penetrate into breast milk, therapy during breastfeeding is also not recommended. If treatment can not be postponed, the child is transferred to artificial feeding.
Special instructions for the use of the drug "Kordaflex"
The ability to reduce blood pressure in this drug is enhanced by the presence of hypovolemia. Reducing the pressure in the pulmonary artery can enhance the therapeutic effect of the drug, so you need to slightly reduce the dosage.
In some cases, at the initial stage of therapy "Cordaflex" or with an increase in dosage may appear chest pain. If the connection between taking the drug and angina is proven, then therapy with this drug will have to stop or adjust the dosage.
It is necessary to abolish the drug gradually, since a sudden discontinuation of the medication can cause hypertensive crisis or myocardial ischemia.
It is necessary to inform about the admission of "Cordaflex" if surgical intervention is supposed.
To observe special care during treatment should be elderly patients, since there is a risk of reducing cerebral blood flow. During the course of treatment, taking alcoholic beverages is not recommended, since blood pressure may sharply decrease.
Any drug has (and is not an exception of "Cordaflex") analogs, synonyms. They differ in such a pharmacological effect on the body and have in their composition the same active substance the following medicines:
- "Kalzigard Retard."
- "Cordaflex Retard."
- "Cordipin HL".
- "Fenigidine" (this, by the way, is the cheapest analogue of "Kordaflex").
- "Corinfar of UNO".
- "Sponify 10".
It should be borne in mind that analogs can not always give the same effect as the original drug. The replacement should always be discussed with the attending physician.
Analogues are produced both by Russian and foreign manufacturers. It should be noted that the latter are sometimes much more expensive than domestic drugs, but nevertheless this does not improve their effectiveness in any way. After all, more expensive does not mean better.
If we talk about "Kordaflex", the Russian analogs are the already mentioned "Nifedipine" and "Fenigidin". These drugs are low in cost, and their effectiveness is quite high.
The cheapest analogue of "Kordaflex"
This is a preparation of Russian production "Fenigidin" (also it is produced in Ukraine). This analogue of Kordaflex is produced not only in tablet form, but also in the form of a solution for intravenous or intracoronary administration.
The active ingredient is the same as in the original drug, nifedipine. Its content in one tablet is 10 milligrams, as in "Cordaflex".
If "Cordaflex" should be taken before meals, then "Fenigidin" can be used during a meal or after eating. The initial dosage should be one tablet twice a day. Usually the duration of therapy is about 1-2 months, but all this individually and is set by the doctor taking into account the severity of the patient's condition.
The peculiarity of the "Fenigidine" tablets is that they can be taken not only inwards, but also sublingually, while the drug is kept in the mouth until it is completely dissolved after chewing. After this, it is advisable for the patient to lie down for about an hour. This method provides a rapid arrest of an attack. In the future, you can take the reception inside.
Doctors believe that the drug has good efficacy, it provides significant help with high blood pressure, angina attacks, but some patients noted a headache during admission.
There is also evidence that during therapy there may be dizziness, muscle pain. But doctors are sure that the appearance of undesirable consequences is most often associated with improper use of the drug.
That is why taking the drug is recommended only under the supervision of specialists. This is especially true when the patient has an acute myocardial infarction, there are disorders of cerebral circulation, diabetes mellitus, and also problems in the functioning of the liver and kidneys. Malignant arterial hypertension also requires careful administration of "Fenigidine".
How not to make a mistake with the choice of medicine
Quite often, the high cost of original drugs becomes an excuse for finding analogues. It has already been noted that the medicines of Russian manufacturers are several times cheaper, and in terms of quality, they are not inferior to foreign medicines.
Before you prefer the original to its analog, you need to discuss this issue with your doctor. Quite often it happens that by purchasing a generic, you can not wait for the effect that is required. And besides, giving preference to analogs, you can easily run into a fake. To avoid this, it is necessary to pay attention to the following points when buying the drug:
- The presence of spelling errors in the instructions to the drug should make you doubt the authenticity of the drug.
- Different font on the package.
- The box or bottle is ajar.
- Engraving on tablets does not have a clear pattern.
- The barcode does not match the country of manufacture.
- There is no information about the manufacturer of the medicine.
- There is no registration number.
- Shelf life is also absent.
If such discrepancies are found, then, most likely, before you is not a real drug, but a fake, and, perhaps, dangerous for your health. At best, such unscrupulous manufacturers made the medicine from the ordinary chalk, well, and at worst it's terrible to imagine what the consequences after the treatment might be.
If during examination of the package with the drug there is any doubt about its authenticity, then the pharmacist can ask for a certificate of quality, he must be on all medications.
Reviews about "Cordaflex" and its substitutes
Any drug can not be equally suitable for all patients, so Kordaflex itself, the analogues, reviews are both positive and negative.
For example, doctors note that the medication has a short-term effect, so the reception is necessary at least 2 times a day. But the great advantage of this drug is the lack of addiction, so at any time it can be replaced by another without consequences for the body.
Patients note that the drug quickly enough normalizes blood pressure. If you take it according to the scheme prescribed by the doctor, and observe the dosage, the indicators always remain within the norm. Well, according to the patients, the medicine is also helpful in case of angina pectoris. With regular admission, repeated attacks almost cease.
There are negative opinions about the drug. Some patients blush after the medication and swelling. Many people notice a severe headache during treatment with this remedy, the appearance of dryness in the oral cavity, may be nausea and vomiting.
Some patients, taking a long time medication, note that cough appears as a side effect.
To reduce the likelihood of adverse events, "Cordaflex" is recommended only after consultation with your doctor. Be sure to follow the dosage and therapy scheme, and if there are existing contraindications, do not rely on what will carry and everything will be fine. It is better to choose another drug than then suffer from side effects.
Any drug before the appointment requires a thorough examination, an accurate diagnosis, so that you can choose the most effective dosage and prescribe the duration of therapy. Do not risk your health, do not self-medicate, this does not lead to good, but only exacerbates the situation. Only a competent specialist can recommend an effective drug and choose a therapy regimen.