The drug "Nitrosorbide" - a fairly common tool. A drug is prescribed for cardiac diseases. The active substance is isosorbide dinitrate.
Medication "Nitrosorbide" instructions for use describes as a peripheral vasodilator from the group of organic nitrates, oral antianginal. The mechanism of action is based on the release of nitric oxide in the smooth muscles of the vessels, a decrease in the activity of protein kinase and other factors contributing to relaxation in smooth muscle vessels (veins, mainly). This, in turn, leads to a short-term decrease in blood pressure, facilitating pre- and post-loading on the myocardium, reducing the need for myocardium in oxygen. Due to the dilatation (expansion) of the capillaries, the oxygen supply and blood supply to the myocardium is improved, it is also possible to reflex acceleration of the heart rhythm.
The drug "Nitrosorbide" (the instruction about it testifies) unlike the preparation "Nitroglycyrinum" is absorbed slowly. With oral intake, the onset of action is observed after thirty to fifty minutes.
Means "Nitrosorbide". Application. Dosage
As an antianginal drug is indicated for the prevention and elimination of angina attacks, in restorative treatment with relapsed myocardial infarction. The medicine is prescribed for heart failure in severe course (as a peripheral vasodilator). In some cases, the drug "Nitrosorbide" instruction for use allows for the appointment of endarteritis and other diseases complicated by angiospasm.
The drug is prescribed to adults. Means "Nitrosorbide" instruction for use recommends taking half an hour before meals three to four times a day for five to ten milligrams. In some cases, single doses increase to 20-30 mg.
In case of cardiac failure in the severe phase, the drug "Nitrosorbide" instructions for use recommends taking 20 ml (two tablets) every four or five hours. In the case of the use of conventional (for oral administration) tablets sublingually (similar to the drug "Nitroglycerin"), probably the arrest of an attack of angina pectoris.
The drug can provoke a number of side effects. These include reflex tachycardia, orthostatic hypotension, skin flushing, drowsiness, nausea, dizziness. In rare cases, it is possible to strengthen angina pectoris, collapse, bradycardia. As practice shows, these reactions are eliminated independently after lowering the dosage.
With continued use of the drug, it is likely that tolerance will develop. In order to prevent this condition, it is recommended to take breaks for 3-5 days after every three to six weeks. During this period, the drug "Nitrosorbide" can be replaced by another antianginal agent.
The drug "Nitrosorbid" is not prescribed for stroke (including hemorrhagic), collapse, shock, TBT. Contraindicated medication with hypersensitivity to nitrates, high intracranial pressure, acute infarction, angle-closure glaucoma with high intraocular pressure, with severe hypotension.
The expediency of taking Nittrosorbide during pregnancy and lactation is determined by the doctor.
The drug is not prescribed simultaneously with sildenafil (a medicine "Viagra").
Overdosage with the drug "Nitrosorbide" manifests itself in the form of dizziness, diarrhea, vomiting, drowsiness, tachycardia, hypotension (pronounced).
To facilitate the condition, the stomach is washed, the patient is transferred to a horizontal position. Symptomatic therapy is indicated.
Before using Nitrosorbide, carefully read the instructions.