Ladisan: instructions for use, feedback

What do patients say about the Ladisan product? Instructions for use, reviews will be discussed further. Also, we will tell you about what this remedy is for, whether it has contraindications and side reactions.

Form, composition

In what form are the medicines "Ladisan" made? Instructions for use inform you that this product can be purchased in the following dosage forms:

• Round tablets coated with a coating and containing 50 or 25 mg of active ingredient - maprotiline hydrochloride.

Also the preparation in question includes such additional substances as lactose, corn starch, talcum, calcium phosphate, dyes, gelatin, colloidal silica , polysorbate-80 and hypromellose. On sale this medicine comes in blisters, which are packed in cardboard boxes.

• Solution for infusions "Ladisan". The instruction says that it has full transparency, and also has no color and is intended for intravenous infusions.

1 ml of the drug solution contains maprotiline methanesulfonate in an amount of 5 mg. Also in the composition of the medicament are auxiliary components in the form of water for injection, mannitol and methanesulfonic acid. The drug goes on sale in ampoules of 5 ml, made of colorless glass.

Pharmacology of a medical device

What is the medicine Ladisan? The instruction, the reviews indicate that this is a drug that belongs to the group of norepinephrine and serotonin reuptake inhibitors. In other words, this medication is an antidepressant of the tetracyclic structure.

The pharmacological action of the active component of this agent consists in the suspension of the reuptake (neuronal) norepinephrine and neurotransmitter serotonin by the presynoptic membranes of neurons of the brain.

The drug in question is distinguished by the correct combination of all the basic properties of drugs from depression. The use of this medicine raises the mood to the patient, removes the habitual feelings of fear, helps to eliminate the excited state, and also removes various somatic disorders and psychomotor retardation, which are typical for disguised depression.

How quickly does the medicine "Ladisan" come on? Instructions for use say that this drug manifests its properties fairly quickly. The therapeutic effect after the use of the agent can be observed after a few days.

It should also be noted that this antidepressant is well tolerated by the human body. That is why he received the widest distribution in outpatient care.

Indications for use of medicament

In what cases can a patient be prescribed a drug such as Ladisan? The opinions of doctors say that it is expedient to use this remedy for various types and manifestations of depression:

• Endogenous (cyclic, involutionary and periodic);
• Somatogenic (organic and symptomatic);
• Psychogenic (depression depletion, reactive and neurotic);
• Disguised forms of depression;
• Depression of the climacteric period.

It should also be noted that this medicine can be used in other disorders, which are accompanied by the following symptoms:

• Apathy;
• Irritability or dysphoria;
• A feeling of fear.

According to the patients' reviews, this medication has a beneficial effect on psychosomatic and somatic disorders that have arisen against a background of anguish or a sense of fear.

Contraindications

This medication can not be used in the following cases:

• The first trimester of pregnancy;
• convulsions;
• Hypersensitivity to the main component;
• Acute myocardial infarction;
• Heart arythmy.

Special Recommendations

When should you not prescribe the antidepressant "Ladisan"? Instruction for use informs that with special care this medicine is recommended for patients with impaired renal or hepatic function, as well as with increased pressure (intraocular) and disorders of urination (including prostate gland diseases).

If this medication is used for a long time, then patients should regularly undergo an ECG and monitor the heart. This is especially true for those who suffer from cardiovascular diseases, including those of advanced age.

Patients who are prone to orthostatic hypotension should regularly check their blood pressure at the time of taking the medication.

It should be borne in mind that, like other psychotropic drugs, this antidepressant significantly reduces a person's tolerance to alcohol.

What else do you need to know before using the medicine "Ladisan"? The patients' reviews say that the drug in tablet form negatively affects their psychophysical reactions, especially if it was taken concomitantly with ethanol or medications that have a depressive effect on the central nervous system.

It should also be noted that when using the "Ladisan" infusion solution, attention and reactions are often disturbed in patients. Therefore, during the period of therapy with this drug, patients are forbidden to drive vehicles and manage dangerous mechanisms.

Antidepressant "Ladisan": instruction for use

The dosage of the drug in question is selected individually for each patient. As a rule, it depends on the severity of the disease.

Experts argue that a decrease or increase in the evening dosage of this remedy is allowed only if the daily dose is increased or decreased. Also, the daily amount of the drug can be taken at a time, preferably in the evening.

After achieving a positive effect, doctors recommend lowering the dose of the medication. However, with the manifestation of repeated symptoms of depression, you must immediately return to the previous treatment regimen.

So how should I use Ladisan tablets? Instruction for use informs that this form of the drug is intended for oral administration.

Typically, with ambulatory therapy of depression, the drug in question is prescribed in an amount of 25 mg three times a day or 50-75 mg once, in the evening.

In the event that the depression is very difficult, then its treatment should be carried out in a hospital. With this diagnosis, the daily dosage of the drug can be increased to 150 mg.

As for the infusion solution, it is usually recommended to inject it with freshly depressed severe depression or if treatment with the oral form of the medication does not bring the desired effect.

The daily dose of the drug for intravenous drip infusion is about 25-100 mg. To prepare the drug solution, the contents of the two ampoules should be dissolved in 250 ml of a solution of sodium chloride or glucose. Further the ready preparation is required to enter slowly into the vein (for 2 hours).

If a patient needs a high dose of medication, then the time of his infusion is increased to 3 hours.

Usually, after the first 2 weeks of treatment with an antidepressant, the patient is transferred to an oral treatment with an infusion solution.

Side reactions

According to the reviews of most consumers, in the early days of using the Ladisan drug, it can cause fatigue, as well as anticholinergic effects such as dry mouth, constipation, disruption of accommodation and dizziness.

In very rare cases, against the background of using the drug in question, the patient has a decrease in blood pressure and tachycardia. Also, skin reactions are possible, which are associated with hypersensitivity of the patient to maprotilene. In this case, you must stop taking the medication.

Cases of overdose

According to the instructions, if used improperly, the Ladisan antidepressant can cause symptoms of an overdose. As a rule, they develop 4 hours after taking the drug and reach their maximum after a day.

Experts attribute the following symptoms to overdosage symptoms:

• Oppression or CNS excitement (including convulsions, restlessness, muscle rigidity, drowsiness, stupor and coma);
• Disorders of the blood vessels and heart (tachycardia, arrhythmia, arterial hypotension and heart failure).

Sometimes, an overdose of the drug in question may provoke vomiting, fever, cyanosis, mydriasis, anuria, increased sweating and oliguria. In this case, symptomatic treatment should be immediately performed.

The drug "Ladisan": reviews of patients

There are not a lot of comments about the antidepressant "Ladisan". In those that are available, patients claim that this drug is quite effective and effective. With proper use, the drug helps to eliminate depressive disorders, as well as apathy, feelings of fear and irritability. However, it should be noted that this agent can cause adverse reactions, so it should only be prescribed by an experienced specialist.