As the pathological processes in human kidneys progress , irreversible changes in this organ appear, its functions either decrease or disappear altogether, which leads to the death of renal tissue and deformation of the kidneys. In this case, the composition of all liquids in the human body is violated, as well as the regulation of blood pressure. Thus, chronic renal failure (CRF) can lead to disruption of the internal organs and cause the onset of death.
This disease develops slowly, the number of people suffering from such a disease is constantly growing.
Doctors diagnose CRF in the case when during three months the kidneys do not function fully. At the end of time, renal tissue atrophies and its regeneration becomes impossible. Kidney cells are gradually dying, and those that have remained are subjected to a double load, so they eventually die, in the human body, about two hundred substances accumulate, so urea and creatinine have high rates and determine the stage of development of kidney failure.
Thus, chronic renal failure has several stages of development:
- Latent period. At this stage, the person begins to feel a slight fatigue and dry mouth, his urine contains protein.
- Compensation stage. Symptoms are the same as in the initial stage, but they increase, the blood and urine composition changes somewhat.
- Intermittent period. Functions of the kidneys weaken, the level of creatinine in urine increases. A person at this stage experiences dry mouth, constant thirst, nausea, there is a rapid fatigue, there are some changes in the skin, weakening of muscle mass, decreases immunity.
- The terminal or terminal stage of chronic renal failure. At the last stage of the development of this disease, changes in human behavior are observed, its reactions are somewhat inhibited due to sleep disturbances, dystrophy is often observed. The skin of a person becomes yellow, his face and abdomen are swollen, and stomatitis appears. In addition, vomiting and diarrhea occur. In this period, the kidneys lose the function of filtration, there is uremia, that is, the presence of urine in the blood. All this leads to the fact that other internal organs are also affected. The most dangerous thing is that this process is irreversible. Often, all this leads to the fact that a person dies, or he needs a kidney transplant.
In the early stages of chronic renal failure, renal function is impaired, leading to the formation of polyuria, edema, hypokalemia, dyspnea and convulsions, as well as dehydration of the whole organism. Over time, ammonia, acetone, various amino acids, uric acid and many other substances accumulate in the urine, which lead to intoxication of the whole organism.
By medicine it is established that the number of people who have chronic renal insufficiency of the first stage is much more than those who are at the last stage of the development of this disease.
Treatment for chronic renal failure should be carried out at early stages of development, otherwise a donor organ will be needed. At these stages, therapy is dispensed with without surgery and is aimed at regulating homeostasis. In addition, a diet with chronic renal failure is necessary, which must be strictly observed, otherwise the kidneys may become worse. Moreover, it is recommended to minimize any physical exertion, eliminate the appearance of stress, take a large amount of fluid. Also in therapy, treatment is used to create the correct metabolism of phosphorus and calcium, as when the metabolism of these substances is disturbed, bone changes are observed. With a severe degree of development of such a disease as chronic renal failure, patients are prescribed replacement therapy with kidney transplantation.