"Keyver" preparation: instructions for use (injections)

If the pain can not be removed by oral ingestion of the drug, then a solution for injection "Keyver" is used. Instructions for the use of shots advise to do with pain syndrome of medium and high severity. This may be the patient's postoperative state, renal colic or lumbar pain.

Composition and form of the preparation

In 1 ml of the solution for injection is 25 mg of the active substance - dexketoprofen. To the auxiliary ingredients of the substance are ethanol in the amount of 96%, sodium chloride, sodium hydroxide and water for injection.

The preparation is a clear, colorless liquid. Packed in glass ampoules, which are enclosed in a cardboard box of 5-10 pieces. Each ampoule contains 2 ml of the drug "Keiver".

Instruction for the application of the injection refers to non-steroidal anti-inflammatory and antirheumatic drugs, which are derivatives of propionic acid.

Pharmacological properties

Dexketoprofen trometamol (the active substance of this drug) is a salt of propionic acid. It is characterized by analgesic, antipyretic and anti-inflammatory properties. Refers to a class of non-steroidal anti-inflammatory drugs, or NSAIDs.

The mechanism of work is aimed at reducing the synthesis of prostaglandins as a result of inhibition of cyclooxygenase. That is, the conversion of arachidonic acid to PGG2 and PGH2 endopeoxides is of a cyclic nature. Of these, in turn, prostaglandins PGEi, PGE2, PGF2a, PGD2 are formed, including such a substance as prostacyclin PGI2, as well as thromboxanes TxAg and TxBg. Suppression of the synthesis of prostaglandins affects the impulses of the inflammatory process, for example, on kinins that affect the basic functions of the drug. The suppressive effect of dexketoprofen on the activity of cyclooxygenase-1, cyclooxygenase-2 was revealed.

Clinical trials have established the analgesic effect of the drug at different degrees of pain syndrome. His analgesic properties were found by injecting the solution inside. An analysis was made of the intensive impact on pain during postoperative intervention. These are orthopedic and gynecological surgical manipulations, as well as abdominal surgery. Use with a different degree of pain in the spine drug "Keiver". Instructions for the use of the injections recommends doing and with renal colic.

Studies have shown that a medical device acts instantaneously, and its maximum effectiveness is manifested for forty-five minutes. The analgesic effect on the body lasts about eight hours, but only if at least 50 mg of "Keyver" (injections) have been injected. Description, indications for the drug - all this is very important to study before using it.

With intramuscular administration of dexketoprofen trometamol, the highest concentration is observed in about twenty minutes. Has a high degree of connection of plasma proteins - 99%. The spread of dexketoprofen varies in the region of 0.25 l / kg. Half-distribution period is 0.35 hours. Displays after 1-2.7 hours.

Indications for use of the drug

It should be injected intramuscularly or intravenously with acute pain syndrome of medium and high degree of intensity of the drug "Keiver". Instructions for the use of shots advise to do only in the event that oral therapy does not help. It is advisable to use them after surgical intervention, with the appearance of renal colic and severe pain in the lumbar region.

Contraindications for use

Has a medicinal "Keyver" (nyxes) indications and contraindications. The second include:

• Hypersensitivity to the active substance dexketoprofen and to additional components of the solution;
• Asthma attacks and bronchial spasms;
• Acute rhinitis, nasal polyps, hives, angioedema;
• Ulcer and bleeding;
• Gastrointestinal bleeding ;
• Crohn's disease or ulcerative colitis;
• Bronchial asthma in the anamnesis;
• Heart failure;
• Kidney diseases of moderate and severe severity;
• Bleeding disorders;
• Severe liver disease;
• Use for neuraxial (intrathecal or epidural) administration;
• Pregnancy, especially III trimester;
• Lactation period.

Do not discount any of these factors in the appointment of the drug "Keiver" (injections). Instructions for use describe all the features of the correct use of this drug.

The drug is not prescribed to small patients due to the lack of knowledge of its effect on the child's body. With caution should take it to the elderly.

The drug "Keiver" (nyxes): instructions for use

For adults, the recommended dose of administration is 50 mg. The interval between injections should be at least 8-12 hours. If necessary, a second injection is carried out after six hours. The daily dose is 150 mg. The drug is used for one-time relief of acute pain. It is not used for more than two days in a row. After the initial pain relief, if the situation allows, the patient is transferred to oral painkillers.

Side effects on the body are reduced by introducing the minimum acceptable dose. After the operation, with painful sensations of strong and moderate severity, the drug is used strictly according to indications. Possible compatibility of the drug with opioid analgesics.

For older people, the dose is not adjusted. But since the metabolic processes in the kidneys in the elderly are slowing down, it is still recommended to reduce the dosage. The maximum permitted dose with a minor disruption of the kidneys is 50 mg.

Patients with ailments of the liver (5-9 points on the Child-Pugh scale) daily dose reduced to 50 mg. After the introduction of the drug into the body, the work of this organ is carefully monitored. At a more severe stage of liver disease, the drug is not prescribed (10-15 points on the Child-Pugh scale).

With a mild kidney disease (creatinine clearance - 50-80 ml / min.), The daily norm should not exceed 50 mg. With an average or severe degree of renal dysfunction, in which the creatinine clearance is <50 ml / min, the drug is strictly prohibited.

The solution for injection is administered intramuscularly and intravenously. When intramuscular manipulation is introduced slowly and deeply enough, "Keiver" (injections).

How to build a drug for intravenous infusion

The liquid in the ampoule of 2 ml for the introduction into the vein should be diluted. To the contents of the ampoule, add 30-100 ml of 0.9% sodium chloride, glucose or lactated Ringer's solution. The liquid for intravenous injection is prepared under sterile conditions. The prepared substance must be absolutely transparent and not have any impurities. Infusion is carried out for ten to thirty minutes. Do not allow daylight sunlight to enter the solution both during its preparation and during the period of drug administration.

"Keiver" (injections in ampoules) instruction recommends for combining with narcotic drugs to breed. To do this, add 100 ml of 0.9% sodium chloride to the ampoule of 2 ml. If necessary, the drug can be diluted with glucose in the same ratio.

It is forbidden to combine "Prometazine" and "Pentazocine" with the "Keyver" medication (injections) in a solution for injections.

How to use the medicine with bolus injection? To this end, a 2 ml solution is not diluted for infusion. Pour in quickly, for fifteen seconds. This time of administration should not be reduced. In small doses, a combination of "Keiver" with such injectable liquids as "Heparin", "Lidocaine", "Morphine" and "Theophylline" is allowed.

Do not mix the injection liquid with small doses of "Dopamine", "Promethazine", "Pentazocine", "Petidin" and "Hydrocortisone." This is recommended because of the risk of a white precipitate, which is highly undesirable during the procedure.

The drug is not subject to even a second storage and should be administered immediately after sampling from a glass ampoule. The solution should also be used immediately after mixing all the necessary medicines. The responsibility for the correctness of the procedure is completely borne by the health worker.

Injection solution after cooking keeps all properties unchanged throughout the day. This condition is feasible if the prepared preparation is completely protected from daylight, and the temperature regime does not exceed 25 ° C.

Ampoule "Keiver" is designed for a single injection. Remains of the solution are immediately disposed of. Immediately before infusion, make sure that the solution is clear and has no color. In the presence of any solid particles, the drug can not be used.

Side effects of the drug

There can be a number of side effects after the administration of the drug "Keiver" (injections). The instruction includes information that quite often there are such phenomena as nausea and vomiting. There is pain in the injection site, bleeding, inflammation and hematoma. Sometimes there is anemia and insomnia, dizziness, drowsiness and headache. Rarely recorded fever and increased fatigue, visual impairment, chills. There were pain in the abdomen, dyspepsia. After a nyxis, diarrhea or constipation sometimes occurs, vomiting with an admixture of blood. Excessive dryness of the oral cavity was noticed. Some patients were disturbed by dermatitis, itching, rashes and excessive sweating.

In rare cases, there are hyperglycemia, hypertriglyceridemia and anorexia. There was paresthesia and unconsciousness. Distressed patients ringing in the ears, extrasystole and tachycardia. In rare cases, symptoms of hypertension, thrombophlebitis, and bradypnoe were recorded. There was an ulcer, jaundice, urticaria, disturbed acne, rigidity of muscles, stiffness of joints. The appearance of muscle cramps and pain in the back area. Partly observed increased urination, renal colic, acetonuria. There were malfunctions of a menstrual cycle and functioning of a prostate. Muscle tremors, peripheral edema were observed.

In exceptional cases, neutropenia was noted in patients, as well as thrombocytopenia. Single examples indicate anaphylactic reactions, for example, anaphylactic shock. Very rare are bronchospasm, dyspnea. Disturbances sometimes pancreatitis and Stevens-Johnson syndrome, epidermal necrolysis. Patients suffer after injection of injections from angioedema, edema of the face, photosensitization. One in ten thousand cases of nephritis and nephrotic syndrome was recorded .

Officially established facts of an overdose have not been identified. At exceeding the recommended doses, the drug adversely affects the digestive tract, causing vomiting, abdominal pain and anorexia. There may be drowsiness and disorientation in space, dizziness, headaches. When revealing the fact of an overdose, one should immediately take certain measures and withdraw the drug from the body with the help of dialysis.

Medication analogues

The drug "Keyver" (injections) is distinguished by a high price. Analogs of this drug can be found in any pharmacy. The ATC code and the active ingredient are the same for the following medicines:

• "Alfort of Dex."
• "Decafene".
• "Delsangin."
• «Delsangin Inject»
• "Depiophene".
• "Rastel".
• "Sertofen".

These drugs can, if necessary, completely replace "Keiver" (injections). Analogues and substitutes for this drug act in a similar manner and have exactly the same active substance, but they should not be selected independently. Before replacing one medication with another, you should consult a doctor who will help you choose the most appropriate option.

Medication cost

The preparation "Keiver" (injections) is produced in Ukraine. The instruction recommends using it not regularly, but only on a case-by-case basis and not more than two days. In Russia, this medicine is not widely used and is not sold in pharmacies, so you can only call an approximate price. It was formed in translation from the hryvnia to the Russian ruble, taking into account the official rate, in which currently 1 UAH. Is equal to 3.21 rubles. In Ukraine, this drug can be bought for 200 hryvnia. In recalculation, the cost will be 640 Russian rubles.

Method of storage and shelf life

Do not store the medical preparation "Keiver" (injections) more than two years from the time of manufacture, indicated on the package. Description of the drug notes that after the expiry date of the drug is unsuitable for use. Store the product in the original box in a temperature mode not exceeding + 25 ° C. The drug should be kept in a cool place inaccessible to children and be protected from direct sunlight.

It is released in pharmacies strictly according to the prescription. The manufacturer is the Ukrainian company PJSC Farmak.

"Keiver" - a reliable and highly effective drug for the purchase of acute pain. Designed for short use. Appeared on the market relatively recently and has not yet managed to win the favor of consumers. It can be purchased both through online pharmacies, and through large pharmacies of large cities of Ukraine.