The drug "Atocor": instructions for use, analog and feedback

High levels of cholesterol in the plasma contribute to the development of atherosclerosis and heart disease.

To carry out lipid-lowering treatment, special means are used, one of which is the drug Atokor. The instruction for this medication describes its hypocholesterolemic and hypotriglyceridemic role in reducing the concentration of harmful cholesterol and other fats in the human body.

general characteristics

The drug refers to inhibitors of 3-methylglutaryl-3-hydroxy-coenzyme reductase. It is produced by the Indian company Doctor Reddy's Laboratories.

At the drug "Atokor" dosage can be on 0,020 and 0,010 g.

Form of issue

The preparation is made in tablet form with a film white coating. Tablets are squeezed out in the form of a triangle with biconvex surfaces, one of which is marked with the letter "A", and on the other there is a dose designation "10" or "20".

Composition

The active ingredient of the drug is atorvastatin, which is represented by micronized calcium trihydrate. At the drug "Atokor" dosage and composition of the quantitative active component are slightly different. Each 0.01084 or 0.02168 g of atorvastatin trihydrate calcium is equivalent to 0.01 or 0.02 g of pure atorvastatin.

Sugar of milk, calcium carbonate, croscarmellose sodium, polysorbate 80, hydroxypropyl cellulose, DT lactose, magnesium stearate formed the structure of the tablet.

The film membrane is formed from hypromellose 15 cps, propylene glycol, talc of purified, titanium dioxide.

The composition is identical for both dosages of the "Atokor" preparation, and the instruction is common.

Tablets of 0.01 or 0.02 g are available in 10 pieces in a blister pack packed in a cardboard box.

Mechanism of action

The drug application instruction refers to selective, competitive moderators of 3-methylglutaryl-3-hydroxy-coenzyme A reductase. It is an important enzyme compound for converting 3-hydroxy-3-methylglutarylcoenzyme A into a mevalonic acid, which precedes styrenes and cholesterol.

If patients have hypercholesterolemia for homozygous, heterozygous familial and non-familial types, as well as mixed dyslipidemia, then taking Atocor medication helps to reduce the concentration of total cholesterol, cholesterol particles in low and very low density lipoproteins, triglycerides and apolipoproteins B.

Medication "Atocor" description of the drug indicates the possibility of tablets unstable to increase the level of useful sterol in high-density lipoproteins.

In liver cells, triglyceride and cholesterol molecules become an integral part of lipoprotein substances, which have a very low density. They go to the plasma, which is penetrated into the tissue peripheral. Of these, low-density lipoprotein compounds are formed that can be catalyzed by interaction with high-affinity-type receptor formations. All these substances can enhance the development of atherosclerosis.

The effect of atorvastatin is characterized by a pronounced and persistent increase in the efficacy of LDL-receptor complexes, a decrease in the concentration of cholesterol harmful for high cholesterolemia of a homozygous hereditary species.

Atokor means the instruction indicates its ability to reduce the plasma level of cholesterol and lipoprotein by inhibiting the HMG-CoA reductase enzyme. It slows the formation of cholesterol in the liver cells, increases the number of receptor formations of lipoproteins with low saturation in cell membranes. This increases the uptake and catabolism of cholesterol molecules from low-concentration lipoproteins.

For what use

Medication "Atokor" instruction on the use of the tablet advises to take at primary signs of increased cholesterolemia of the heterozygous type, local and non-local increase in the concentration of cholesterol, mixed heterylipidemia, an increased number of plasma triglyceride molecules.

They are prescribed in combination with dietary prescriptions to lower the high cholesterol level in lipoproteins with low saturation, apolipoproteins B and triglyceride compounds.

Tablets reduce the plasma concentration of cholesterol in LDL with increased cholesterolemia of homozygous family type, when dietary nutrition and other non-pharmacological methods are ineffective.

How to use

Medication "Atokor" instructions for use recommends drinking only after the appointment of a patient with a standard hypocholesterolemic diet, which should be used in the therapy. Dosing is set for each patient separately, which is calculated from the initial level of cholesterol in lipoproteins with low saturation. It is important to consider the purpose, effectiveness of therapy with the drug "Atokor", the testimony.

Typically, the initial dosing is equal to 0.010 g per session per day. The use of tablets does not depend on the time of day and eating.

Dosage daily amount from 0.010 to 0.080 g is selected from the initial indicators of harmful cholesterol, target prerequisites and personal effectiveness. At the initial stage of application and with increasing the concentration of the drug should be in half a month to check the level of plasma fat, and if necessary adjust the dose.

Primary hypercholesterolemia and combined hyperlipidemia are treated with a daily dosage of 0.010 g.

Therapeutic activity comes in 14 days, and the maximum effectiveness is possible after one month. Long-term use allows you to maintain therapeutic effect.

Medications "Atokor" instruction in Russian contains information on the therapy of hypercholesterolemia for a homozygous family type. Usually appoint a daily dosage of 0.080 g. With such an application, the LDL cholesterol is reduced to 40%.

Features of treatment

Atocor tablets instructions for use strongly recommend that before starting to use the drug should find the cause of the secondary increase in the value of cholesterol. Such factors include weak therapy of diabetes mellitus, hypothyroidism, nephrotic process, dysproteinemic changes, obstructive hepatic disease. Here it is possible to carry still treatment by other medical products and alcoholic dependence. Only after getting rid of the above reasons, you can start using the tablets "Atokor".

Even before therapy, lipid balance is determined between total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides.

There is no data on the use of medication in pediatric practice, so these tablets are not prescribed to children.

In the treatment of elderly patients, whose age is more than 60 years, there is an increase in the plasma level of the active component of the drug to 40%.

If there is a violation of renal function, there is no need to adjust the dose, since this condition does not affect the atorvastatin content in the blood stream and the effectiveness of reducing harmful cholesterol.

There is evidence that the use of drugs of this class cause the development of rhabdomyolysis myopathy and insufficient kidney function in acute form. With such diseases, the medicine should be abandoned for a while.

Preparations based on atorvastatin should be taken cautiously by people who abuse alcoholic beverages or have had hepatic diseases in the past.

Under the action of retarders of the HMG-CoA-reductase enzyme, changes in the biochemical performance of the liver are possible. To timely establish such violations, it is necessary to assess the liver activity before treatment, and then re-check 3 months after taking the tablets.

Medication "Atokor" instruction in Russian includes information on a noticeable increase in the plasma value of the active ingredient in patients with hepatic diseases that suffer from alcoholism. Temporary or complete refusal of therapy returns the transaminase activity of the liver to the original framework. Many patients did not abolish the use of the drug in small doses, and there were no undesirable reactions.

During treatment, the head may become dizzy, a drowsy condition may develop, so patients are not allowed to drive transport or other complex devices for the time of tablet use.

Who can not use

On the drug "Atokor" contraindications include increased sensitivity to each ingredient of the medication.

It is not taken in acute liver diseases and with high activation of transaminase serum enzymes, when their activity is 3 times higher than the value of the upper limit of normal indices.

The drug is not prescribed to women in their reproductive age, who do not use adequate contraceptives. Contraindication is the condition of bearing and breastfeeding.

The medicine does not treat children and adolescents until the age of 18.

Due to the presence of sugar dairy in the tablets "Atokor" instructions for use prohibit their use with hereditary intolerance to galactose molecules, with a lack of lactase and malabsorption of galactose-glucose.

Analogues

There is a large number of drugs based on atorvastatin. Hypocholesterolemic role is assigned to the drug "Atokor" instructions for use. Analogs are also able to lower the level of bad cholesterol in a person's blood.

One of such medicines is the Slovenian medicine "Atoris", the manufacturer of which is the joint-stock company "KRKA, Novo mesto". Produced in the form of tablets with an active ingredient content of 0.010 g, 0.020 g, 0.040 g.

The drug is designed to eliminate the hyperlipidemic state, in which it is necessary to reduce the total cholesterol, cholesterol in low-density lipoprotein compounds, the number of apolipoprotein and triglyceride molecules in the bloodstream.

The drug treats people with hypercholesterolemia of polygenic, heterozygous homozygous family type.

Using the drug "Atoris" increases the concentration of cholesterol in lipoproteins with high saturation.

Another Slovene analogue is the drug "Tulip", which is produced by the company "Lek Pharmaceutical Company". There are three dosages of tablets with a film coating: 0.01 g, 0.02 g and 0.04 g.

The drug is prescribed to eliminate the primary form of hypercholesterolemic and combined hyperlipidemic state, for the therapy of increased cholesterol value of heterozygous and homozygous family type.

A similar tool is the Indian medicine Astin, which is manufactured by Micro Labs Limited. Produced in two doses: 0.010 grams and 0.020 grams of atorvastatin.

The drug is prescribed with increased lipid content, when there is no positive effect of dietary nutrition and other activities.

The Indian manufacture is the "Storvas" medication based on the calcium salt of atorvastatin. Produced by the company "Ranbaxy Laboratories Limited" in the form of a tablet with a coating in two doses: 0.010 g and 0.020 g.

The drug "Storvas" reduces the increased content of total cholesterol, cholesterol molecules in LDL, the concentration of apolipoprotein and triglyceride compounds in primary, heterozygous familial and non-family hypercholesterolemic state, as well as in mixed hyperlipidemic disease.

The medication reduces the possibility of the development of myocardial infarction, strokes and changes in the cerebral circulation. Tablets slow the progression of coronary atherosclerosis.

The American analogue is the drug "Lipimar", which is produced by Pfizer. Produced in the form of coated tablets in three dosages: 0.010 g, 0.020 g, 0.040 g. The drug is also used to eliminate hypercholesterolemic status of different types of origin.

Reviews

The drug "Atokor" instructions for use characterize it as a means with high proven effectiveness. Many patients suffering from an increased concentration of plasma harmful cholesterol, after the course of use becomes better. The values of total cholesterol, as well as LDL are reduced to a normal level, at which the probability of development of atherosclerotic and ischemic conditions decreases.

The drug refers to drugs with good tolerability, but in some patients it can cause stool retention, bloating, abdominal pain, nausea, indigestion. There are headaches, sleep is disturbed. A convulsive, asthenic and myalgic condition may develop.

In rare cases, side effects are manifested by myositis, myopathy, paresthesia, peripheral neuropathy, pancreatitis, hepatitis, cholestatic jaundice.

Tablets can cause anorexia, vomiting, hepatotoxic manifestations, alopecia, itching manifestations in the form of rashes, impotence, cataracts, hyper- or hypoglycemia.