Instructions for use "Tiapridal." Analogues and reviews

"Tiapridal" is an antipsychotic drug made on the basis of tiaprid. The medication is used as a sedative, analgesic and hypnotic. The basis of antipsychotic action is the blocking of dopamine receptors, which significantly affect the functioning of the central nervous system. In this article we will describe in detail about the preparation.

Form release, components of the drug

The drug is available in two forms, you can buy tablets and solution:

• One tablet, like one ampoule, includes 100 milligrams of the main component and excipients. As auxiliary ingredients in the composition used are povidone, magnesium stearate, mannitol. The composition is also supplemented with microcrystalline dioxide of aqueous colloidal, silicon and cellulose.
• In addition to the main component, the solution contains sodium chloride and water for injection.

In one box contains 20 tablets (2 blisters for 10 tablets) or 12 ampoules (2 blisters for 6 ampoules). Instructions for the use of "Tiapridal" in the form of a solution for injection can be administered intravenously and intramuscularly. This form of the drug is suitable only for the treatment of adult patients.

Pharmacodynamics of Tiapridal

The drug has neuroleptic, analgesic and anxiolytic effects. As the instructions for use show, Tiapridal selectively blocks the functioning of the D ₂ receptors of central dopamine. At the same time, there is no effect on D ₁ -receptors. The drug allows you to get rid of dyskinesia, when used in the elderly improves your thinking.

Pharmacokinetics of Tiapridal

When intramuscular injection of the drug (200 mg), its maximum level in the body is detected after 30 minutes, when using tablets at the same dose - after 60 minutes. Bioavailability at use of a preparation at once before reception of nutrition from 75% increases up to 95%. As a result of this use of the drug, its maximum level in the body also increases (by 40%).

Absorption in the body of elderly patients is slower. "Tiapridal" instructions for use refer to drugs that penetrate the placental and blood-brain barrier. It is known that during the therapy the drug is present in the composition of breast milk. In women, partial excretion of the drug occurs faster than in men (2.9 hours), the difference is 0.7 hours. Metabolism is characterized as moderate. The bulk of the drug (70%) is removed from the body by the kidneys in an unchanged form.

Indications for the use of the drug "Tiapridal"

To implement therapy with the use of the drug "Tiapridal" the readings look like this:

• Dyskinesia (late, spontaneous);
• Gilles de la Tourette's syndrome;
• chorea;
• Behavioral disorders (aggressive states, excitation, etc.), which arise mainly in alcoholism of chronic course and in elderly patients;
• Negative behavioral manifestations, such as aggression and agitation;
• Painful sensations of an intense nature (chronic forms).

Contra-indications, restrictions to reception of a preparation "Tiapridal"

Prohibits the appointment of "Tiapridal" instruction for children aged less than six years. In pediatrics, therapy is done only with pills. The drug can not be treated pregnant women and patients who are breastfeeding. The drug is not used for hypersensitivity to its components and other similar remedies. Contraindications include such conditions:

• Hepatic and renal failure, which is significant;
• Diagnosis of prolactin-dependent neoplasm, suspected of its presence;
• Hypertensive crisis;
• Diagnosis of pheochromocytoma, suspicion of its presence.

Tablets and solution are not used together with "Sultopride" and dopamine receptor agonists (the exception is treatment of patients with Parkinson's disease), do not combine with some types of neuroleptics, antiarrhythmics belonging to classes III and I A.

Treatment with TiAdridal medication does not allow the instruction to be performed simultaneously with the use of Moxifloxacin, Sparfloxacin, Difemannila, Erythromycin, Bepridil, Mizolastina, Levadopa, Cisapride and intravenous administration of Vinkamina .

If the patient (especially the elderly) is treated with drugs that can lead to hypokalemia, worsening of cardiac conduction, prolongation of the QT interval, the emergence of a bradycardia of a pronounced character, use "Tiapridal" with caution. Caution is also required in such cases:

• Parkinson's disease;
• Prolongation of QT interval of congenital character;
• Hypokalemia;
• Chronic course of renal failure;
• Bradycardia;
• Diseases in which the work of the cardiovascular system is disrupted (decompensation stage);
• epilepsy.

Treatment with TiAdpril

Instructions for use "Tiapridal" first recommends the use in small doses, gradually increasing them, in order to obtain maximum effect.

Behavioral disorders

For their relief, 200 mg of the drug (up to 300) must be applied daily. The positive effect is achieved in an average of one and a half month. Elderly patients are prescribed a smaller dose of the drug - 50 mg. A single dose should be consumed twice a day, while its increase is allowed with a certain interval, this action is performed gradually, taking into account the recommendations of a specialist. The daily dose can not exceed 300 mg.

Chronic Intensive Pain

The daily dose of the drug for treating such conditions is from 200 mg to 400.

Chorea, Gilles de la Tourette's syndrome

When the child is treated, the daily dose of the drug is selected taking into account the body weight and is 3-6 mg / kg. If treatment is required for an adult, first 25 mg of medication per day is used, later (after a gradual increase in the dose), 300-800 mg.

Agitation, aggression

The recommended daily dose of the drug is from 100 mg to 150.

Behavioral disorders

The recommended dose for daily use (from 200 to 300 mg) in the case of development of delirious or pre-dilerious state increases to 400-1200 mg. The maximum possible dose, which can not be exceeded, is 1800 mg. The preparation is administered on average with an interval of five hours. If treatment is necessary for an elderly person, 2-3 injections are done every day, between which an interval of 6 hours is observed. For the treatment of such patients, the daily intake of 200 mg of the drug is recommended to 300. At a time, not more than 100 mg of Tiapridal is allowed to be administered.

Intensively pronounced chronic pain

Therapy is based on the administration of a daily dose corresponding to 200-400 mg of the drug.

Side effects when taking the drug "Tiapridal"

When treatment with the drug "Tiapridal" instructions for use, reviews confirm the likelihood of some adverse reactions. There may be irregularities in the work of the genitourinary, nervous, endocrine and cardiovascular systems. In addition, there is a risk of problems with the senses. Other adverse events include allergies, accompanied by skin manifestations, weight gain, orthostatic hypotension.

Overdose of Tiapridal

When using an overestimated dose of the drug, an overdose is possible, its symptoms are disorders of consciousness, the most serious of which is coma, neuroleptic syndrome (malignant, acute forms). With the aim of eliminating this state of the body, treatment based on cholinolytic agents is carried out. After the withdrawal of the drug, symptomatic treatment and plasmapheresis is necessary.

special instructions

Before using the drug "Tiapridal", the instructions for use recommend correcting hypokalemia. During therapy it is important to constantly monitor the electrolyte balance, conduct an electrocardiogram, monitor changes in the clinical picture.

If, as a result of taking neuroleptics, an extrapyramidal syndrome develops, anticholinergic drugs should be used instead of the dopamine receptor agonist.

For the duration of treatment, it is worth noting activities that present a potential danger, it is not recommended to perform works that require special care and quick response.

Interaction with other substances

The combination of some drugs with taking the medicine "Tiapridal" instruction, reviews are associated with the likelihood of unwanted reactions of the body. It is not recommended to apply Clonidine, antihistamines, anxiolytics, barbiturates and opioid analgesics during the period of therapy, since the action of Tiapridal will be more pronounced. Because of incompatibility, do not take "Levodopa" and alcohol. The medication can be combined with the use of neurotropic drugs, analgesics, antidepressants, neuroleptics. A high risk of orthostatic hypotension exists with simultaneous use of antihypertensive drugs with "Tiapridal".

The cost of the medicinal product, analogues, reviews about the drug "Tiapridal"

If necessary, treat the "Tiapridal" with the instruction, the description allow you to find out what the drug is. The price of the medicine is of no small importance when choosing a medicament for therapy. A solution in ampoules can be bought for about 995 rubles, and tablets - for 1400 rubles.

Among the analogues of the medication are "Eglonil", "Betamax". From substitutes can be chosen "Sulpirid" or "Prosulpin". There is another analogue of the drug - Tiaprid, it is considered the most affordable, it is quite a popular option, a domestic medicinal product, the production of which is handled by the company "Organica". In the composition of Tiaprid, the same active substance is present, which is a part of the drug TiAdpril. Instructions for use of analogs advise to choose when the original can not be used simultaneously with certain drugs, causes side effects or does not provide the desired effect. To make the drug the most effective, many choices are taken into account when choosing it.

During the treatment period it is important to follow all the doctor's advice and recommendations, which contains instructions for use. "Tiapridal", as the reviews show, in most cases used to remove conditions accompanied by nervous excitement and aggressive behavior, alcoholic psychosis. Usually patients and doctors are satisfied with the result of therapy. Basically, a second course is not required because the desired effect develops after the implementation of the first course. The reviews show that for patients the medicine "Tiapridal" is convenient to use.