"Ibuprom": instructions for use, feedback

Nonsteroidal anti-inflammatory drugs occupy a strong leading position in the pharmaceutical markets around the world. These means of complex action have antipyretic, anti-inflammatory and analgesic effects on the human body. One of these medicines is Ibuprom. The instruction regulates it as a very effective remedy for a variety of diseases.

Pharmacodynamics of the preparation

Ibuprom is a phenylpropionic acid derivative. The mechanism of influence is based on the suppression of the activity of COX (an enzyme, a precursor of prostaglandins, which in turn predominate in the processes of pathogenesis, the development of painful and feverish sensations). Moreover, the drug is characterized by nonselective inhibition of cyclooxygenase, i.e. Ibuprom equally suppresses the activity of both isoforms of this enzyme-COX-1 and COX-2.

The analgesic effect of the drug "Ibuprom" instructions for use causes two mechanisms - peripheral and central. The first is manifested indirectly through the inhibition of the production of prostaglandins. The effect of the second mechanism (central) is to suppress the production of the same prostaglandins in the central and peripheral regions of the NS. Due to the decrease in the lipid active substances present in the inflammatory focus, the sensitivity of receptors for chemical stimuli is reduced. In the hypothalamus in the center of thermoregulation, suppression of the synthesis of prostaglandins leads to a decrease in body temperature in febrile states.

In addition, tablets "Ibuprom" (the instruction to the preparation contains such information) to some extent suppress the aggregation (gluing) of platelets.

Composition and form of the drug

Ibuprofen is the main active ingredient of Ibuprom. As auxiliary components, crospovidone, silicon dioxide, polyethylene glycol and a number of other substances (gelatin, starch, vegetable oil, sucrose, etc.) can be mentioned.

The forms in which the medication is offered to consumers are several. The drug can be packed in a sachet, in a polyvinyl vial (50 tablets) or in blisters.

Depending on the volume of the main component, the preparation is referred to as Ibuprom (200 mg ibuprofen in one tablet) or about the medicine Ibuprom Max (400 mg ibuprofen). However, that's not all. About such a variety, as "Ibuprom Sprint Caps", the instruction says that the drug is released in capsules with a dose of 200 mg of the main active substance in each. "Ibuprom Extra" is also offered to patients in capsules, the volume of the main component in each is 400 mg. About the "Ibuprom Sinus" instruction says that one tablet contains 200 mg of ibuprofen and 30 mg of pseudoephedrine hydrochloride.

Indications for use

The description of all the symptoms, when a positive effect will be obtained, contains an instruction for a remedy such as Ibuprom tablets. The composition (analogues of a medicament with the same active substance will have approximately the same effect) suggests that the drug will give a positive result in the treatment of diseases such as any inflammatory-degenerative problems in the spine and joints. There is no exception to arthritis (rheumatoid, rheumatic, psoriatic), osteoarthritis, ankylosing spondylitis. Assign "Ibuprom" for inflammation of soft tissues and musculoskeletal system caused by trauma, with radiculitis, bursitis, tendinitis. In addition, the medication is able to cope with headache and toothache, with neuralgia, myalgia, with pain syndrome with infectious and inflammatory diseases of the ENT organs. Medical workers practice the appointment of "Ibuprom" in feverish conditions for lowering body temperature, with pain sensations of mild or moderate moderation and of unknown origin.

"Ibuprom Max" instructions for use recommends taking if there is the same symptomatology when an increased dose of the drug is required. "Ibuprom Extra" will also be effective with such symptoms.

"Ibuprom Sinus" (synonym - "Ibuprom Sprint Caps") is usually prescribed to provide analgesic, anti-inflammatory and antipyretic effects, as well as to reduce swelling of the mucous nasal and its adnexal sinuses. That is, the drug will be effective in the symptomatic treatment of colds, ARI and influenza, accompanied by headache, sore throat and muscles, high body temperature and inflammation of the nasal mucosa and paranasal sinuses.

Possible applications

Ibuprom (tablets) recommends the use of the instructions for each patient individually, depending on the intensity of the clinical manifestations of the disease. The standard scheme of taking this medication is a single dose in the amount of 200 to 800 mg, with a frequency 3-4 times during the day. For small patients, the dosage is chosen depending on the body weight - 20-40 mg per kilogram of weight (this daily volume), divided into several receptions throughout the day. The course of therapy usually lasts from 2 to 3 weeks. The maximum allowable dose per day for an adult patient is 2.4 g. It is taken during or after a meal and washed down with a small amount of liquid. To divide the tablet into parts is undesirable.

"Ibuprom Max" is taken irrespective of food, and it is required to drink it with a sufficient volume of water. Part of the tablet is undesirable.

As for "Ibuprom Sprint Caps", for patients over 12 years of age, a single dose is 1-2 capsules with a frequency of every 4-6 hours. Take it in the process of eating or after. For elderly people, there is no need to select a dose specifically, except for cases of clearly manifested kidney and liver functioning.

"Ibuprom Extra" instruction recommends taking 1 capsule every 4 hours (we are talking about patients over 12 years old), but not more than 3 capsules during the day. The medication is taken after a meal, not chewed. For elderly patients, there is no need to select a dose specifically.

"Ibuprom Sinus" take 1-2 tablets before meals and wash down with water. Periodicity - every 4-6 hours. Maximum of 6 tablets per day is acceptable.

Contraindications to taking medication "Ibuprom"

"Ibuprom" (tablets) instructions for use forbid those who have an increased hypersensitivity to ibuprofen or any auxiliary components of the drug. It is unacceptable to prescribe medication to patients suffering from lesions of the digestive tract of an erosive-ulcerative nature (especially in the phase of exacerbation). It is also forbidden to treat with Ibuprom in the presence of an aspirin triad and with certain diseases of the optic nerve. Deviations in the functioning of the hematopoiesis system are also grounds for refusing to use any drugs from the NSAID group. It is not the practice of this medication to be administered to those patients in whom marked abnormalities in kidney and liver function are observed.

It is unacceptable to prescribe and apply Ibuprom in parallel with other non-steroid medicines.

As for the medicine "Ibuprom Max", the tablet is forbidden to take the instructions for use under the same problems as Ibuprom itself.

"Ibuprom Extra", in addition to all the contraindications described above, is not prescribed if patients have hemorrhagic diathesis, in case of cardiac insufficiency. Also, you should not take this medication if you are dehydrated due to vomiting, diarrhea, or lack of fluid.

The medicine "Ibuprom Sinus" has all the above contraindications. In addition, it is not used for bronchial asthma, diabetes, with an elevated level of thyroid hormones (hyperteriosis). Contraindication is the presence in patients of pheochromocytoma (neoplasms in the tissues of the adrenal glands), hyperplasia (adenoma) of the prostate gland.

Negative manifestations

How is Ibuprom transferred? The instruction contains information on the possibility of developing some side effects from different systems and organs against the background of taking this remedy. The greatest number of reactions to the use of this NSAID is observed on the part of the gastrointestinal tract. Patients talk about nausea, vomiting, discomfort in the epigastric region, the development of anorexia and ulcerative-erosive lesions of the mucous digestive tract.

From the side of the central nervous system often there are headaches, dizziness, agitation, abnormalities in the processes of sleep and visual perception. Probable reactions from the hematopoietic system with long-term medication are anemia, thrombocytopenia, agranulocytosis.

Various allergic manifestations are possible on Ibuprom. Tablets (the instruction contains such information) can provoke the appearance of a rash, the development of Quincke's edema. In very rare cases, the emergence of aseptic meningitis (the most susceptible to this reaction people with autoimmune diseases), bronchospastic syndrome. As local manifestations, patients claim sensations of burning and tingling on the skin, and hyperemia.

Ibuprom Sinus, in addition to all of the above, can lead to the development of shortness of breath, tachycardia, increased blood pressure, hyperhidrosis.

Exceeding the permissible dose: consequences

In case of an overdose with such medicines as Ibuprom and Ibuprom Max, the instructions for use indicate the possible development of nausea and vomiting, pain in the epigastrium. Also, in such a situation, drowsiness, dizziness, headaches and dizziness may occur, blood pressure may decrease and the arrhythmia develop. In severe situations, symptoms of metabolic acidosis manifest themselves, and loss of consciousness may occur with impaired respiratory function.

In such conditions, urgent rinsing of the stomach and the appointment of symptomatic treatment are recommended. Practice oral intake of enterosorbents. The convulsive syndrome is removed with the help of "Diazepam", "Lorazepam".

In case of an overdose of Ibuprom Sprint Caps, in addition to all the above, there is a possibility of disorientation, convulsions, coma. Possible liver dysfunction. Patients suffering from bronchial asthma may become aggravated by the course of the disease.

Long-term use of the drug "Ibuprom Sinus" can cause pathological changes in the blood, such as hemolytic anemia (increased disintegration of red blood cells), granulocytopenia (decrease in the number of granulocytes), thrombocytopenia (decrease in platelet count).

What should I look for?

"Ibuprom" instruction recommends taking with caution those who have concomitant diseases of the liver, kidneys, chronic heart failure. If the patient has diarrheal symptoms before the beginning of therapy, or the patient has just undergone surgery, it is also necessary to begin treatment with Ibuprom with great care. The presence in the anamnesis of information about bleeding of any nature, about diseases of the digestive tract, allergic manifestations associated with the treatment of nonsteroidal anti-inflammatory drugs, should also become an occasion for careful consideration of the patient's condition.

To avoid unpleasant surprises, it is necessary to constantly monitor the functions of the kidneys and liver, the picture of peripheral blood during the application of Ibuprom.

And the "Ibuprom" and "Ibuprom Max" instruction does not recommend applying in the 3rd trimester of pregnancy. In the first and second trimesters, the use of this NSAID is justified only if the expected positive effect for the mother exceeds the possible negative consequences for the child.

Ibuprofen, the main active ingredient of Ibuprom, is excreted in small doses with breast milk, so it is possible to use it during lactation in order to stop pain and febrile conditions. However, if there is a question about prolonged therapy with the help of Ibuprom or about the need to take large doses, it should be discussed with the doctor about the refusal of breastfeeding.

The use of Ibuprom Sinus during pregnancy and breastfeeding is contraindicated.

Interaction with other drugs

Any form of Ibuprom (Ibuprom Max, Ibuprom Sprint Caps, Ibuprom Extra) instructions for use prohibits taking in parallel with antihypertensive agents and diuretics such as furosemide, hydrochlorothiazide, as their therapeutic effect can be significantly reduced.

The use of Ibuprom in tandem with antiplatelet and selective serotonin inhibitors increases the risk of developing bleeding. Further, this NSAID is able to increase the glycosides in the blood plasma and, thus, cause an exacerbation of heart failure. Ibuprom will strengthen the effect on the human body of anticoagulants. For this reason, it is important to regularly monitor blood coagulability, because ibuprofen significantly reduces platelet aggregation.

When used in parallel with lithium preparations and "Methotrexate", the level of these substances in blood plasma will significantly increase. Tandem with cyclosporine will lead to an increase in the nephrotoxicity of the latter.

The combination of Ibuprom with digitalis preparations (digitalis) can cause the development of cardiac arrhythmia. You can not also take this NSAID in tandem with acetylsalicylic acid (aspirin), since there is a possibility of increasing negative side effects.

The combination of quinolone antibacterial agents and any NSAIDs (and Ibuprom, among others) increases the risk of developing a convulsive syndrome. A combination with a medication such as Zinovudine increases the risk of hemarthrosis and hematomas in HIV-infected patients.

Opinions of patients about the drug

Nonsteroid PVA are serious drugs with, as a rule, a wide range of effects. Therefore, patients' reviews of such remedies are always positive as well as negative. Ibuprom is not an exception.

The bulk of people taking the drug, was satisfied with its effect. Painful sensations quickly stop and for a long time do not remind of themselves. The drug has proven itself in painful menstruation, headaches and myositis, with myalgia and neuralgia.

At the same time, there are patients who were dissatisfied with the influence of the medicine Ibuprom. The instruction states the rapid development of the effect of anesthesia, but many consumers did not feel the effects of this drug at all. In addition, many complained of adverse reactions in the form of nausea and headaches.

A fairly large group of people complained that "Ibuprom" did not completely take off the toothache. Although in this case, do not say that the drug is bad. The fact is that, for example, with acute pulpitis, no painkillers will help, except for injecting directly into the gum. In the case of toothache, Ibuprom is an opportunity to get to the dentist as soon as possible without experiencing severe pain.

In any case, NSAIDs are a new generation of dehydrating and anti-inflammatory drugs that are effective in a very wide range of pathologies. This is the opinion of most consumers and health professionals.