Dostineks - instructions for use, reviews

This article describes the pharmacological effect of the drug from the group of dopamine receptors - the drug "Dostinex," the instructions, reviews on its use.

The international name of the drug: "Cabergoline" (Cabergoline), from the group of dopamine receptors is an agonist. The active substance of the drug is cabergoline. Release dosage form - tablets.

Pharmacological action: It is a dopamine stimulating agent, an ergoline derivative, suppresses the hypersecretion of STH, reduces the secretion of prolactin. Having a stimulating effect on receptors of lactotropic cells of the pituitary gland, "Dostinex", the instruction emphasizes this, it has a central dopaminergic effect in high doses. There is a stabilizing effect on the concentration of prolactin in the blood, normalizes the menstrual cycle and restores fertility. Due to a decrease in prolactin, women are recovering pulsatile secretion of gonadotropins, LH released in the middle of the cycle. The lactorrhea decreases. In men, some types of impotence are eliminated, as the level of testosterone rises with a decrease in prolactin content; Gynecomastia is treated. By restoring the neurochemical state of the black core of the brain and the striped body, "Dostinex," the instruction points to it, alleviates depressive symptoms, tremors and stiffness, softens the symptoms of Parkinson's disease. Concentration of prolactin is normalized after 2-4 weeks of therapy.

Indications: "Dostinex" is prescribed for postpartum lactation (suppression or prevention); Hyperprolactinemia, accompanied by a malfunction of the menstrual cycle (oligomenorrhea, amenorrhea, anovulation); Galactorrhea; Infertility. It is indicated for impotence and decreased libido in men; Prolactin secreting adenomas of the pituitary gland; Diopathic hyperprolactinemia.

Contraindications to the use of the drug " Dostinex" : The instruction prohibits prescribing the drug for hypersensitivity (including other ergot derivatives), pregnancy, breastfeeding, postpartum psychosis (in the anamnesis), postpartum hypertension, pre-eclampsia, in children (up to 16 years).

Side effects with the use of the drug " Dostinex" : Side effects are moderately expressed, can occur during the first 2 weeks, and go without additional treatment. Side effects from the nervous system can be in the form of: dizziness, headache, insomnia; With prolonged therapy - in the form of: weakness, drowsiness, depression.

In the digestive system, side effects are manifested by symptoms: nausea, dry mouth, epigastric pain; With prolonged therapy: vomiting, constipation, gastritis. In the CCC manifestations in the form of: lowering blood pressure, palpitations; Rarely - orthostatic hypotension. Other manifestations are in the forms: mastodynia, lowering of Hb level, restoring menstruation; Nosebleeds; Transient hemianopsia; Allergic skin reactions.

Methods of using the drug " Dostinex": Instructions prescribe to take the drug inside, during meals. For the prevention of postpartum lactation - after childbirth, on the first day - 1 mg once. In order to suppress the available lactation - by 1/4 mg - 2 times / day - 2 days. For the treatment of hyperprolactinemia - 1 / 4-2 mg / week. It is recommended to increase the weekly dose at a rate not exceeding 1/2 mg / month. The maximum permissible weekly dose is 4.5 mg.

Drug Interactions: Macrolides increase the possibility of side effects (increase the content of "Dostinex" in plasma). Derivatives of butyrophenone, phenothiazine, metoclopramide, thioxanthene reduce the effect of the drug. Combined use with ergot alkaloids and hypotensive drugs is not recommended.

Digest: Many patients express a positive effect on taking "Dostinex" in order to suppress lactation. Most people say that the breasts are shrinking almost "before our eyes." Reduction of prolactin in the blood was noted even with a small dose of the drug. In some cases, side effects were observed in the form of nausea, dizziness.

Summarizing the reviews of people who took "Dostinex," you can understand that the drug in most cases proved to be quite effective for lowering the level of prolactin, very effectively fighting lactation. There are almost no negative reviews, although some indicate side effects.

Before you start using the drug "Dostinex", be sure to consult a doctor!