NSAIDs of the latest generation: reviews, list, prices

A variety of pathological changes occurring in the body, accompanies the pain syndrome. To combat such symptoms, NSAIDs or non-steroidal anti-inflammatory drugs have been developed. They perfectly anesthetize, relieve inflammation, reduce swelling. However, the drugs have a lot of side effects. This limits the possibility of their use for some patients. Modern pharmacology has developed NSAIDs of the latest generation. Such drugs are much less likely to cause unpleasant reactions, but they remain effective drugs against pain.

Principle of impact

What is the effect of NSAID on the body? They affect cyclooxygenase. COX has two isoforms. Each of them carries its own functions. Such an enzyme (COX) causes a chemical reaction, as a result of which arachidonic acid passes into prostaglandins, thromboxanes and leukotrienes.

COX-1 is responsible for the production of prostaglandins. They protect the gastric mucosa from unpleasant effects, affect the functioning of platelets, and also affect the change in renal blood flow.

COX-2 is normally absent and is a specific inflammation enzyme synthesized by cytotoxins, as well as other mediators.

This action of NSAIDs, like inhibition of COX-1, has many side effects.

New developments

It is no secret that preparations of the first generation of NSAIDs had an adverse effect on the gastric mucosa. Therefore, scientists set a goal - to reduce undesirable effects. A new form of output was developed. In such preparations, the active substance was in a special shell. The capsule was made from such substances that did not dissolve in the acidic environment of the stomach. They began to break down only when they hit the intestine. This allowed to reduce the irritating effect on the gastric mucosa. However, the unpleasant mechanism of damaging the walls of the digestive tract is still preserved.

This made chemists synthesize completely new substances. From previous drugs, they are fundamentally different mechanism of action. NSAIDs of the new generation are characterized by a selective effect on COX-2, as well as oppression of prostaglandin production. This allows you to achieve all the necessary effects - analgesic, antipyretic, anti-inflammatory. At the same time, NSAIDs of the latest generation allow minimizing the effect on blood coagulability, platelet function, and gastric mucosa.

The anti-inflammatory effect is due to a decrease in the permeability of the vessel walls, as well as a decrease in the production of a variety of inflammatory mediators. Due to this effect, irritation of the nerve pain receptors is minimized. Influence on certain centers of thermoregulation, located in the brain, allows NSAIDs of the last generation to perfectly lower the overall temperature.

Indications for use

Widely known NSAID effects. The effect of such drugs is aimed at preventing or reducing the inflammatory process. These drugs give an excellent antipyretic effect. Their effect on the body can be compared with the influence of narcotic analgesics. In addition, they provide an analgesic, anti-inflammatory effect. The use of NSAIDs reaches a wide scale in clinical settings and in everyday life. For today it is one of the popular medical medicines.

Positive impact is noted with the following factors:

1. Diseases of the musculoskeletal system. With different stretches, bruises, arthroses, these medications are simply irreplaceable. Used NSAIDs for osteochondrosis, inflammatory arthropathy, arthritis. The drug has an anti-inflammatory effect in myositis, herniated intervertebral discs.
2. Strong pains. The drugs are used successfully for biliary colic, gynecological ailments. They eliminate the headache, even migraine, kidney discomfort. NSAIDs are successfully used for patients in the postoperative period.
3. Heat. Antipyretic effect allows you to use drugs for various ailments to adults and children. Such drugs are effective even with fever.
4. Thrombosis. Preparations of NSAIDs are antiaggregants. This allows them to be used for ischemia. They are a preventive remedy for heart attack and stroke.

Classification

About 25 years ago, only 8 NSAID groups were developed. Today, this number has increased to 15. However, the exact figure even doctors can not be called. Having appeared on the market, they quickly gained wide popularity of NSAIDs. The drugs replaced opioid analgesics. Since they, unlike the latter, did not provoke respiratory depression.

Classification of NSAIDs implies a division into two groups:

1. Old drugs (first generation). This category includes well-known medicines: Citramon, Aspirin, Ibuprofen, Naproxen, Nurofen, Voltaren, Diclac, Diclofenac, Metindol, Movidid, Butadion .
2. New NSAIDs (second generation). Over the past 15-20 years, pharmacology has developed excellent drugs, such as Movalis, Nimesil, Naize, Celebrex, and Arkoksia.

However, this is not the only classification of NSAIDs. Medicines of the new generation are divided into non-acid derivatives and acids. Initially, consider the last category:

1. Salicylates. This group of NSAIDs contains preparations: "Aspirin", "Diflunizal", "Lysinmonoacetylsalicylate".
2. Pyrazolidines. Representatives of this category are preparations: "Phenylbutazone", "Azaprobane", "Oxyphenbutazone".
3. Oksikam. These are the most innovative NSAIDs of the new generation. List of drugs: "Piroxicam", "Meloksikam", "Lornoxicam", "Tenoxicam." Medicines are not cheap, but their effect on the body lasts much longer than other NSAIDs.
4. Phenylacetic acid derivatives. Such a group of NSAIDs contains funds: Diclofenac, Tolmetin, Indomethacin, Etodolac, Sulindak, and Aceclofenac.
5. Preparations of anthranilic acid. The main representative is the medicine "Mefenaminat".
6. Means of propionic acid. This category contains many fine NSAIDs. List of drugs: Ibuprofen, Ketoprofen, Benoxaprofen, Fenbufen, Fenoprofen, Tiaprofenic acid, Naproksen, Flurbiprofen, Pirprofen, Nabumeton.
7. Derivatives of isonicotinic acid. The main medicine is Amizon.
8. Preparations of pyrazolone. To this category belongs the well-known "Analgin".

Non-acid derivatives include sulfonamides. This group includes preparations: "Rofecoxib", "Celecoxib", "Nimesulide".

Side effects

NSAIDs of the new generation, the list of which is given above, are distinguished by effective action on the body. In this case, they practically do not affect the functioning of the digestive tract. The difference between these drugs is another positive aspect: NSAIDs of the new generation do not exert a destructive effect on cartilaginous tissues.

However, even such effective agents can provoke a number of undesirable effects. They should be known, especially if the drug is used for a long time.

The main side effects can be:

• dizziness;
• drowsiness;
• headache;
• Fatigue;
• Increased heart rate;
• Increased pressure;
• Slight shortness of breath;
• dry cough;
• indigestion;
• The appearance of protein in the urine;
• Increased activity of hepatic enzymes;
• Skin rash (spot);
• Fluid retention;
• allergy.

In this case, damage to the gastric mucosa is not observed when taking new NSAIDs. Preparations do not cause an exacerbation of the ulcer with the appearance of bleeding.

Recommendations for use

The best anti-inflammatory properties are preparations of phenylacetic acid, salicylates, pyrazolidones, oxicams, alkanones, propionic acid and sulfonamide drugs.

From joint pain, the most effective medications are Indomethacin, Diclofenac, Ketoprofen, and Flurbiprofen. This is the best NSAID for osteochondrosis. The abovementioned medicines, with the exception of Ketoprofen, have a pronounced anti-inflammatory effect. This category includes the means "Piroxicam".

Effective analgesics are preparations Ketorolac, Ketoprofen, Indomethacin, Diclofenac.

The leader among the NSAIDs of the last generation was the drug "Movalis". This tool is allowed to use a long period. Anti-inflammatory analogues of an effective medicine are preparations "Movasin", "Mirloks", "Lem", "Arthrosan", "Meloks", "Melbek", "Mesipol" and "Ameloteks".

The drug "Movalis"

This drug is available in the form of tablets, rectal suppositories and solution for intramuscular injection. Means refers to the derivatives of enol acid. The preparation differs excellent anesthetizing and antipyretic properties. It has been established that practically with any inflammatory processes this medicine brings a favorable effect.

Indications for the use of the drug are osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.

However, you should know that there are contraindications to taking the medicine:

• Hypersensitivity to any of the components of the drug;
• Peptic ulcer in the stage of exacerbation;
• Severe renal insufficiency;
• Ulcerous bleeding;
• Severe hepatic impairment;
• Pregnancy, feeding the child;
• Severe heart failure.

Do not take the drug for children under 12 years.

Adults who are diagnosed with osteoarthritis are recommended to use 7.5 mg per day. If necessary, this dose can be increased by 2 times.

With rheumatoid arthritis and ankylosing spondylitis, the daily norm is 15 mg.

It is extremely cautious to take the drug patients prone to the occurrence of side effects. People who have renal failure and who are on hemodialysis should take no more than 7.5 mg throughout the day.

The cost of the drug "Movalis" in tablets of 7.5 mg, No. 20, is 502 rubles.

Opinion of consumers about the medicine

The reviews of many people who are prone to severe pain, show that the drug "Movalis" - the most suitable means for a long reception. It is perfectly tolerated by patients. In addition, its prolonged presence in the body makes it possible to take a single dose of the drug. A very important factor, according to most consumers, is the protection of cartilaginous tissues, since the drug does not adversely affect them. This is very important for patients who use the remedy for osteochondrosis, arthrosis.

In addition, the medicine perfectly relieves of various pains - dental, headache. Particular attention is paid by patients to an impressive list of side effects. During the intake of NSAIDs, treatment, despite the manufacturer's warning, was not complicated by unpleasant consequences.

The drug "Celecoxib"

The action of this remedy is aimed at alleviating the patient's condition with osteochondrosis and arthrosis. The drug perfectly eliminates pain syndrome, effectively removes the inflammatory process. There was no adverse effect on the digestive system.

Indications for use, given in the instructions are:

• Psoriatic arthritis ;
• Osteoarthritis;
• rheumatoid arthritis;
• Ankylosing spondylitis.

This drug has a number of contraindications. In addition, the medicine is not intended for children under 18 years of age. Special care must be taken in people who are diagnosed with heart failure, because the drug increases the predisposition to fluid retention.

The cost of the drug varies, depending on the packaging, in the region of 500-800 rubles.

Consumer opinion

Quite contradictory reviews about this drug. Some patients have been able to overcome joint pain due to this remedy. Other patients claim that the drug did not help. Thus, this tool is not always effective.

In addition, do not take the drug yourself. In some European countries, this medicine is prohibited, since it has cardiotoxic effects, which is quite unfavorable for the heart.

The drug "Nimesulide"

This drug has not only anti-inflammatory and anti-pain effects. The product also has antioxidant properties, due to which the drug inhibits substances that destroy cartilaginous tissues and collagen fibers.

The agent is applied when:

• Arthritis;
• Arthrosis;
• Osteoarthritis;
• Myalgia;
• Arthralgia;
• Bursitis;
• Fever;
• Various pain syndromes.

The analgesic effect of the drug is very fast. Typically, the patient feels relieved within 20 minutes after taking the drug. That's why this tool is very effective in acute paroxysmal pain.

Almost always the medicine is well tolerated by the sick. But sometimes there may be side effects such as dizziness, drowsiness, headache, nausea, heartburn, hematuria, oliguria, urticaria.

The remedy is not allowed for pregnant women and children under 12 years of age. With extreme caution, people who have hypertension, the functioning of the kidneys, eyes, or the heart should take Nimesulide.

The average price of the medicine is 76.9 rubles.

What do consumers say?

Reviews about the drug is almost always positive. Because the medicine perfectly removes pain and reduces heat, it perfectly fights against inflammatory processes.

Many patients note that the relief of symptoms occurs quickly enough, and the duration of its effect is about eight hours.

An excellent remedy perfectly eliminates dental, traumatic, arthritic pain. The drug is able to relieve the discomfort caused by the pinching of the nerve.

The drug "Xefokam"

This medicine belongs to the group of oxycomas. This NSAID group has an increased half-life, resulting in prolonged exposure to the drug. This allowed to significantly reduce the frequency of medication. Consequently, the risk of side effects decreases.

The drug "Xefokam" is characterized by the highest ability to relieve pain. Its analgesic effect on the strength of manifestation is comparable to morphine. However, unlike the latter, the drug is not addictive and does not affect the central nervous system.

During testing, it was noted that the drug eliminates pain for 12 hours.

The cost of the drug in tablet form (8 mg) per packing No. 10 is 205 rubles.

The drug "Rofecoxib"

The drug has anti-inflammatory analgesic, anti-edematous and antipyretic effect. Assign an effective remedy for the following ailments:

• Chronic periarthritis;
• rheumatoid arthritis;
• Tendonitis;
• bursitis;
• Trauma of tendons of ligaments, muscles.

At the same time, the painful symptoms caused by neuralgia, osteochondrosis and pulpitis are effectively eliminated by the drug "Rofecoxib". The remedy perfectly eliminates lumbago, toothache, radicular syndrome.

The drug can not be taken by patients with bronchial asthma, after a heart attack, stroke. Do not use it for people with cancer, arterial hypertension and atherosclerosis. The drug is prohibited for children under 12 years. In addition, before use, it is advisable to carefully examine the possible side effects.

The drug "Parecoxib"

This is an excellent tool, allowing to reduce inflammatory reactions and contributing to the decrease in the sensitivity of pain receptors. The drug is in demand for patients who underwent surgery.

It eliminates painful syndromes of moderate and strong intensity. It is prescribed after endoprosthetics of the hip and knee joints, hysterectomy, coronary artery bypass grafting, is used in dental practice.

Dosage of the drug is purely individual. It depends on the clinical situation and the indications. Children under 18 years of age are not prescribed medicine.

The drug "Arkoksia"

The drug has another name - "Etorikoksib." It has high anti-inflammatory, analgesic properties. The drug helps to suppress the pain impulse.

Patients with ailments of the musculoskeletal system with the help of this remedy get rid of morning stiffness. They have an improvement in the mobility of the joints, decreases the intensity of inflammation, and perfectly corrects the pain syndrome. After taking the therapeutic effect comes within twenty-four minutes. The active substance of the drug is perfectly absorbed with the bloodstream. The drug is highly bioavailable. This indicator is 100%.

The dose of the drug may be prescribed only by a doctor. As a rule, it varies from 60 mg to 120 mg throughout the day.

The drug is not intended for use by pregnant women and children under 16 years of age.

Conclusion

Modern pharmacology does not stand still. New, more effective NSAIDs are being developed. A list of excellent new-generation drugs, given above, allows you to choose the best remedy for any pathology. However, it should be remembered that these drugs are not able to cure the disease. They have only an anti-inflammatory and analgesic effect.