"Tizin Xylo BIO": instructions for use, description, composition and reviews

Life with a runny nose loses its charm, because people are concerned about headaches, nasal congestion, difficulty breathing, irritation of the mucous membrane and a stream of discharge from the nose. At this point, you want to quickly get rid of the disease, and an excellent assistant in this situation will be "Tizin Xylo BIO." He quickly removes stuffiness, reduces irritation, restores normal breathing. Has a natural composition. Even children can use it (from two years old).

Composition and form of the preparation

"Tisin Xylo BIO" is a nasal spray. It has the non-proprietary international name "Xylometazoline".

Produced in a dosage of 0.05% and 0.1% of 10 ml. The drug is packaged in polyethylene bottles of white color, which have a dispensing device and a lid. In the box, in addition to the vial is an instruction for use. The volume of the bottle (10 ml) is calculated for 140 doses.

The preparation contains the active component xylometazoline hydrochloride: 0.5 mg for a dosage of 0.05% and 1 mg for 0.1%. The volume of the active substance in one pea for 0.05% is 0.035 mg of xylometazoline hydrochloride; For 0.1% - 0.14 mg. Auxiliary elements are glycerol, purified water, sorbitol, sodium hyaluronate, sodium dihydrogen phosphate dihydrate, sodium phosphate dihydrate and sodium chloride.

The solution is a colorless and transparent liquid with a slight yellowish hue.

Pharmacological characteristics

Spray "Tizin Xylo BIO" is an anticongestive medicine (vasoconstrictor).

The active substance - xylometazoline - refers to the derivatives of imidazole. This alpha-adrenergic stimulator removes the swelling of the nasal mucosa in minutes and restores breathing in rhinitis.

Hyaluronic acid delicately helps to restore the normal operation of the nasal cavity, removes dryness. Supports mucous in moistened condition.

The effect of the drug begins 5-10 minutes after administration.

The medicine is intended only for topical application and is almost not absorbed by the walls of the nasal cavity. The concentration of the active component in the blood reaches that minimum value when it is not possible to determine it by analytical methods. Pharmacokinetic studies in humans have not been conducted.

The effect of "Tizin Xylo BIO" during pregnancy and during breastfeeding has not been studied. It is also unknown whether the active ingredient enters the breast milk. Therefore, in these periods of life from the use of nasal spray is better to abandon.

Indications for use

The drug helps to remove swelling of the nasal mucosa in rhinitis. It can be a hay fever, allergic rhinitis or ARI with symptoms of rhinitis.

The drug promotes the rapid removal of mucus in paranasal sinusitis. A similar action of the spray is also observed in the inflammatory processes of the middle ear caused by the common cold.

"Tizin Xylo BIO" for children of the age group 2-6 years has a dosage of 0.05%. Adults and children from 6 years of age are prescribed a drug with an active substance concentration of 0.1%.


When treating with Tizin Xylo BIO, a small number of patients (≥ 1%) can have unpleasant consequences. Therefore, it is worth to abandon the use of nasal spray, if there is a hypersensitivity to any of the substances contained in its composition. Prohibition to use is atrophic rhinitis, thyrotoxicosis. Do not use the drug to treat newborns and toddlers up to two years. Do not use the drug in patients with severe forms of cardiovascular disease, such as ischemic heart disease, severe atherosclerosis, tachycardia, hypertension, angina. Refrain from the therapy of spray should people who have undergone surgery on the brain.

Careful use of the drug, carefully considering the benefits and risks, should be used by people using monoamine oxidase (MAO) inhibitors or similar agents that increase intraocular pressure. Particular attention should be paid to the effect of the drug with narrow-angle glaucoma. Care should be taken by patients with pheochromocytoma, people with impaired metabolic functions (diabetes mellitus), and patients with prostatic hyperplasia.

Tizin Xylo BIO: instructions for use

Nasal spray is prescribed by a doctor only for topical use. Thus, adults and children's groups from six years old are shown a drug with a dosage of 0.1%. In this case, the drug is used up to three times a day. Each time, only one portion of the drug is administered into the nasal passageway. The daily dose may vary depending on the individual characteristics of the organism, the sensitivity to the drug and the achievement of a clinical effect.

Babies at the age of 2 to 6 years are shown "Tizin Xylo BIO" (the instruction for use advises to consult a doctor before using the medication, as improper treatment can provoke the most negative effects on the body) with an active substance concentration of 0.05%. The drug is administered one dose in each nostril once or twice a day.

Nasal Spray should not be used for more than five days. Repeatedly this preparation can be used only after a few days.

In chronic rhinitis, the drug is used only under the supervision of a doctor, since there is a risk of atrophy of the nasal mucosa.

Adverse events

Not so harmless is the nasal spray "Tizin Xylo BIO". For children (the instruction on the application is attached and should be studied before the beginning of treatment), the use of this remedy may result in negative reactions, however, adults can also suffer. The drug can cause a slight irritation of the nose, which manifests itself in the form of sneezing or burning.

According to experts, reactive hyperemia or swelling of the nose is often enough after the withdrawal of the remedy. Prolonged use of xylometazoline or excess of recommended doses sometimes lead to a burning sensation in the nose and excessive dryness of the mucosa. Even in this situation, a nasal congestion with progressive medicamentous rhinitis may occur. Some patients experience paresthesia, hypersecretion and sneezing. Such phenomena can continue for a week after completion of treatment. Prolonged use in some cases provokes the development of chronic inflammatory processes of the nasal mucosa that cause the formation of dry crusts and are diagnosed as dry rhinitis.

On the part of the nervous system, headache, sleep disturbances, insomnia, depressive conditions, excessive fatigue, and a malfunction in the visual apparatus were identified.

In a few cases, the cardiovascular system suffered. Intranasal use of sympathomimetics caused a number of phenomena such as arrhythmia, increased heart rate, tachycardia, and an increase in the blood pressure index.


Spray "Tizin Xylo BIO" (the instruction strongly recommends adhering to the indicated doses) in cases of overdose or with accidental administration of the medicine can cause the following symptoms:

  • Dilated pupils;
  • Nausea and vomiting;
  • Fever;
  • Muscle cramps;
  • Cyanosis of the skin;
  • Tachycardia and arrhythmia;
  • collapse;
  • Stopping the work of the heart;
  • Hypertension;
  • Psychoneurological failures;
  • Violation of normal breathing;
  • pulmonary edema.

Overdose can provoke the suppression of the functioning of the entire central nervous system of the body, in which there is drowsiness, a decrease in body temperature, bradycardia, a significant decrease in blood pressure, respiratory arrest, coma.

If the body has been injected with a drug that exceeds the norm, you should drink activated charcoal and wash the stomach. In some cases, artificial respiration with oxygen is indicated.

To reduce pressure, doctors recommend using 5 ml of "Fentolamin", diluted with saline for intravenous administration. You can also take 100 mg of this drug inside. Do not use vasopressor drugs. If necessary, you can resort to antipyretic or anticonvulsant drugs.

special instructions

As already mentioned, the use of the drug "Tizin Xylo BIO" for children (reviews say that it helps to quickly restore breathing, but also causes burning sensation in the nose) can turn into trouble. Therefore, do not use the remedy for more than seven days, as this can provoke reactive hyperemia of the nasal mucosa. As a result, the feeling of stuffiness is constantly observed, which causes you to use the spray again and again. There is an addiction to the drug. This process provokes chronic edema of the nose, ozona.

In order to avoid dependence on the drug, it is necessary to inject the solution alternately into one and the other nostril with prolonged use. This will reduce the impact of sympathomimetic and provide partial breathing.

Interaction with drugs

When the nasal spray "Tizin Xylo BIO" is combined with MAO inhibitors from the discharge of tranylcypromine or with antidepressants of the tricyclic series, an increase in blood pressure may be observed. And also disruption of the cardiovascular system.

Tizin Xylolo BIO: reviews

Nasal spray has caused a lot of controversy. People say that the drug is good, but only for short-term use, as it is addictive, so it should be used strictly according to instructions and not more than a week. Patients note that it quickly removes puffiness and restores breathing "Tizin Xylo BIO". The reviews draw attention to the fact that he removes allergic stuffiness, runny nose, spray is convenient to use. It is worth the drug is inexpensive, while fully coping with its task. Does not dry the mucous membrane of the nose due to the presence of hyaluronic acid in the composition. Economical. Has a long tip, easy to use.

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