The medicine "Metrogil" (intravenously). Instructions

The drug "Metrogil" (intravenously) refers to antimicrobial and antiprotozoal drugs. The active substance of the drug is metronidazole. The drug shows its activity relative to a number of gram-positive bacteria, obligate anaerobes. In combination with amoxicillin Helicobacter pylori acts. Resistant to the drug exhibit facultative anaerobes, aerobic microorganisms. The drug increases sensitivity to irradiation of tumors, provokes disulfiram-like manifestations, stimulates repair processes.

The medicine "Metrogil" (for intravenous administration). Pharmacokinetics

With an infusion of 500 mg for 20 minutes, the maximum content of the drug in the blood is noted in an hour. Metabolism is subjected to about 30-60% of the drug. The main metabolite has antimicrobial and antiprotozoal effects. About 60-80% leaves with urine, with feces it is deduced up to 15% of a medicine.

Appointment

The drug is indicated for the treatment and prevention of infectious lesions caused by sensitive microbes. In particular, the drug is recommended for surgical interventions in the urinary tract and abdominal organs. The indications should include sepsis, hepatic and intestinal amebiasis in severe form, osteomyelitis, abscesses of the brain, small pelvis. The medication "Metrogil" (intravenously) is prescribed for lesions of soft tissues, skin, bones, articular infections, gynecological pathologies. The drug is recommended for radiotherapy of tumors (as a radiosensitizer in cases of neoplasm resistance caused by hypoxia in its cells).

Application Scheme

Initial dosage to patients from 12 years - from half to one gram of drip. The duration of the infusion is thirty to forty minutes. Each subsequent 8 hours, the drug is administered 500 mg each. The infusion rate is then 5 ml / min. With satisfactory tolerability, after 2-3 first infusions, a jet injection is used. The duration of therapy is a week. A day is allowed not more than 4 g. For patients under 12 years of age, the "Metrogil" medication (intravenously) is prescribed according to this scheme in a single dosage of seven and a half milligrams per kilogram. For the prevention of complications during surgical interventions, patients from 12 years of age are prescribed before surgery from 0.5 to 1 g per day and on the following day for 1.5 g / day. (0.5 mg every 8 hours). When used as a radiosensitizing agent, the administration is carried out dropwise at 160 mg / kg or 4 to 6 g / m ^{2 of} the body surface. The infusion is performed half an hour before the irradiation.

Side effect of the drug "Metrogil" (intravenously). Reviews

As practice shows, while observing the infusion rate and the dosing regimen, undesirable consequences develop rarely. According to the specialists' observations, patients satisfactorily tolerate therapy. Seldom there can be infringements in activity GASTROINTESTINAL TRACT, nervous system. On the basis of hypersensitivity, the development of an allergic reaction is likely. Some patients had convulsions, hallucinations, impaired appetite, mouthfeel of the metal.