The drug "Pangrol": instructions for use, composition, indications, reviews

In what dosage is the medication "Pangrol" prescribed? Instructions for using this medication will be described in this article. It also provides information about the composition of the drug in question, whether it has contraindications and side effects.

Form of release of the medicament and its packaging

In what form do they produce Pangrol? Instructions for use, doctors' reviews indicate that this product is on sale in the form of hard and opaque gelatin capsules of cylindrical form, as well as tablets.

The skin of this medicine has a light orange color, and the capsule cover is a yellow-green tint.

The contents of the capsules are cylindrical granules. They have a shiny surface and an enteric coating, and also differ in light beige color.

In what packaging is the medicine "Pangrol" sold? Instructions for use with the drug (20, 100 or 50 capsules) are embedded in a polypropylene bottle. The medicament in question is tabletted into a blister pack and placed in cardboard packs.

Composition of the medicinal product

What is included in the composition of the drug "Pangrol" 10000? Instruction for use informs us that the active substance of this drug is pancreatin. Also in the composition of the medication include such additional elements as croscarmellose sodium, magnesium stearate, castor oil hydrogenated, silicon dioxide colloidal anhydrous and microcellulose.

The same composition has and preparations "Pangrol" 20000 and 25000.

Pharmacological properties of the drug

What is the medicine "Pangrol"? Instructions for use (the composition of this drug was described above) states that this medication belongs to the group of digestive-enzyme agents. After oral administration, it helps to fill the deficiency of substances that are extremely necessary for the normal functioning of the pancreas.

Also, the drug in question is capable of providing amylolytic, proteolytic and lipolytic effects.

Pharmacodynamics of the preparation

How does the drug "Pangrol" work 25,000? Instructions for use say that pancreatin, which is part of this drug, is a powder obtained by processing the porcine glands (pancreas). The enzymes contained in it favorably influence digestion processes, and also accelerate the breakdown of carbohydrates, fats and proteins. Also, this substance helps normalize the work of the pancreas itself.

What properties does Pangrol have? The instructions for use suggest that by improving the digestion of food, this medication effectively removes such signs of digestive disorders as a feeling of fullness of the stomach, shortness of breath, pain and heaviness in the abdomen, accumulation of gases, flatulence and so on.

Taking the capsules and tablets, the patient stimulates the pancreas, as well as the stomach and small intestine, which subsequently produce all the necessary enzymes involved in the digestive process.

The bile extract included in the preparation acts on the human body choleretically, and also enhances the emulsification of fats. Thus, it increases the activity of lipase, improving the absorption and digestion of the fat-soluble vitamins A, E and K.

Pharmacokinetics of medicament

How does the drug "Pangrol" 20000? Instruction for use gives a lot of information on this. The drug "Pangrol" is covered with a special acid-resistant shell, which helps to protect the drug from the effects of gastric juice until the agent enters the small intestine. In this case, the capsule shell dissolves rather quickly, after which it releases granules that contain digestive enzymes. Mixed with the contents of the intestine, they provide it with the necessary level of enzymes.

For more effective exposure, it is very important to maintain a slightly alkaline or neutral pH in the small intestine.

It should also be noted that the drug "Pangrol" is not absorbed from the digestive tract. In this case, it is excreted from the body only together with feces.

Indications for use

This drug is actively used as a replacement therapy in adults and young children with disrupted exocrine pancreas.

In addition, the drug "Pangrol" is prescribed with relative enzyme deficiency, which was caused by one of the following diseases:

• Pancreatitis (including chronic and acute stages of the disease);
• Pancreatic cancer or narrowing of the duct, which was caused by the presence of a malignant tumor or gallstones;
• Intestinal infections;
• Syndrome Shvakhman-Diamond;
• Disorders of the gastrointestinal tract, which are of a functional nature;
• Irritable bowel syndrome;
• Cystic fibrosis.

It should also be said that the drug in question is actively used to prepare a patient for X-ray examination or ultrasound of the abdominal cavity, as well as for normalizing the function of the stomach and pancreas after surgery (for example, after resection or as part of complex therapy after irradiation If there are signs such as flatulence, not digesting food or diarrhea).

Contraindications for use

At what conditions is it not recommended to take the medicine "Pangrol"? Instructions for use (the indications of this medication were listed above) indicate the following prohibitions:

• Acute pancreatitis;
• Hypersensitivity of the patient to drug substances;
• Exacerbation of pancreatitis.

The drug "Pangrol": instructions for use

According to the instructions, this drug should be taken with food. In this case it is not recommended to chew (should be swallowed whole).

Tablets and capsules should be taken with a liquid of room temperature. The dose of the drug is determined by the doctor and depends on the patient's condition, as well as the form and severity of the disease.

When administering capsules, the following therapeutic doses should be adhered to:

• Adults - 1-2 or 2-4 capsules of the drug "Pangrol" 25000 or 10000, respectively;
• Small children - is calculated as follows: 500-1000 units of medicine per 1 kg of weight at each meal.

As for the tablets, they are taken on 1-2 pieces during each meal. The average therapeutic dose of this medication can vary depending on the disease, as well as the food that the patient uses.

If necessary, the doctor may increase the daily dosage. However, it is necessary to adhere to the maximum permissible limits, equal to 15000-20000 units of lipase per 1 kg.

How long should therapy last? The course of treatment depends on the type, severity of the disease and the state of human health.

If the patient can not take the whole capsule (for example, elderly people or small children), then its contents can be poured into a liquid or mixed together with food that does not need to be chewed (for example, fruit puree). It should be especially noted that a mixture of food and tablets is forbidden to be stored. It must be used immediately.

For the treatment of cystic fibrosis, the dosage of the drug is also selected by the doctor. As a rule, it depends on the body weight of the patient.

The initial dose of the drug for children under 4 years should be 1000 units per 1 kg of weight, and for children older than 4 years - 500 units.

When using a medicine in pediatrics, it is necessary to follow the diet, in order to exclude the development of steatorrhoea.

Cases of overdose

Overdosage with the drug "Pangrol" and increasing the number of enzymes in the treatment of cystic fibrosis can signal such diseases as hyperuricosuria and hyperuricemia. In this case, the drug should be withdrawn, and then immediately consult a doctor.

Adverse events

During treatment with Pangrol, patients may develop side effects such as diarrhea, bloating, nausea, digestive system disorders, vomiting, abdominal pain, and others.

Very rarely, people taking this medicine have an allergic reaction (itching, hives, skin rashes). If such symptoms are found, stop using the drug and consult a doctor.

Special Recommendations

During the treatment of cystic fibrosis, fibrosing colonopathy can develop in people receiving large doses of medication (that is, stricture of the blind, thick and ileum). In order to avoid such pathologies, a medical examination must be made before the medication is taken in order to exclude the presence of intestinal lesions in the patient.

Analogues and price of the drug

Now you know what the drug "Pangrol" is used for. Instructions for use (the analogs of this medication will be listed right away) of the mentioned agent has been described in detail above.

If you could not buy this drug in your region, it can be replaced by one of the following analogues (after consulting a doctor): "Gastenorm Forte", "Hermitage", "Creon", "Pancrelipase", "Mezim", "Enzistal- P, Mikrazim, Penzital, Mezim Forte, PanziKam, Pancreatin Forte, Panzinorm, Festal, Pancreatin, Pancitrat, Pansinorm Forte, Pancreatin-LekT "," Panzim Forte ".

The cost of the drug in question depends on the form. Packing with 50 tablets can be purchased for 1000 rubles, and 20 capsules - for 250 rubles.

Reviews about the drug

In most cases, people taking the drug "Pangrol", leave positive feedback. This drug effectively copes with the task. The only drawback is the difficulty in calculating the dose. In view of the fact that digestion problems are always individual, only an experienced specialist can choose the right dosage. This fact significantly complicates the independent use of the drug.