Serenata tablets: instructions for use, analogues, reviews

Diseases of the nervous system are widespread in our country. For their treatment, there are many drugs. One of these medicines is the "Serenata" medication. The instruction notes that the doctor's consultation is mandatory before using the medication.

Composition and form of the drug

Produced in the form of tablets coated with a film membrane, the drug "Serenata." The instruction fully describes the composition of the medicament, which includes the active substance sertraline hydrochloride. As additional elements were involved:

• microcrystalline cellulose;
• Sodium carboxymethyl starch;
• Anhydrous calcium hydrogen phosphate;
• Giprolose;
• Magnesium stearate;
• Polysorbate.

The shell of the tablets consists of hypromellose, titanium dioxide and propylene glycol.
The medicine is produced in tablets of 50 mg and 100 mg. They are a biconvex capsular form. They have white color and risk on the one hand. Packed in 10 tablets in an aluminum blister. In the cardboard bundle can be from 3 to 5 blisters plus instructions for use.

The medicine is stored at a temperature not exceeding 25 ° C. The drug should be in a place protected from the sun and inaccessible to children. Shelf life of the drug is three years from the date of manufacture of the drug. Do not use tablets after this time.

The medication is dispensed from pharmacies only on prescription. A medicine is being manufactured in India.

Pharmacological features of the drug

The medicinal product "Serenata" (the instruction for use is sold together with the tablets and must be carefully studied before the drug is used) refers to antidepressants. Produces a strong selective inhibitor of reuptake of serotonin. It has little effect on the re-uptake of dopamine and norepinephrine. If the drug is used in therapeutic doses, the active substance of the drug inhibits the capture of serotonin in the platelets of the human body.

As a result of clinical trials, it was noted that the drug does not have sedative, stimulating and anticholinergic effects. During the reception of the tablets, the subjects did not notice any psychomotor disturbances.

The medication is not addictive and does not affect the body weight, even with prolonged intake of tablets.

Tests on animals showed that sertraline does not increase catecholamine activity. It is not characterized by affinity for serotonergic, muscarinic, histaminergic, dopaminergic, GABA-, benzodiazepine and adrenergic receptors. It is noted that the "Serenata" tablets do not have cardiotoxic properties.

Prolonged use of the drug in animals was used to stabilize the noradrenaline receptors that are located in the brain and are of the negative feedback type. This action is typical for many anti-obsessive drugs and antidepressants.

The "Serenata" tablets (the instruction completely describes the method of taking the medication and informs about the recommended dosage) are not addictive, so patients do not abuse them.

When should I use the medicine?

The drug "Serenata" is recommended for use with prolonged depressive conditions. The medicine is prescribed to prevent depression of various etiologies. The purpose of the pill is obsessive-compulsive disorders that occur in both the adult population and in children from six years of age. Prescribe medication for panic disorders, which can be accompanied by agoraphobia. Use pills under stress, which has arisen as a result of the transferred trauma. Indications for use are social anxiety disorder, which is also called social phobia.

Contraindications

The drug "Serenata" instruction for use does not recommend taking with hypersensitivity to sertraline and additional elements that are part of the drug. Do not prescribe medication to children under six years of age, this concerns obsessive-compulsive disorders. In all other cases, the drug "Serenata" (pills) is not prescribed until eighteen years.

It is forbidden to use sertraline simultaneously with monoamine oxidase inhibitors. In this case, there is a risk of a serotonin syndrome, which can manifest as agitation, hyperthermia, as well as limb tremor.

Treatment with tablets should be started after two weeks, after stopping the intake of monoamine oxidase inhibitors. The "Serenates" should be stopped at least seven hours before the beginning of treatment of MAOI irreversible action. It is forbidden to use the drug simultaneously with pimozide, tryptophan or fenfluramine.

Carefully use sertraline for patients suffering from organic pathologies of the brain, epilepsy, renal and hepatic insufficiency. Having a pronounced weight loss. You should be careful when sharing sertraline with medicines that increase serotonergic neurotransmission. This applies to those drugs that affect platelets.

Follow closely the patients taking tricyclic antidepressants and sertraline at the same time.

The drug is forbidden to use during pregnancy and breast-feeding.

Serenata medicine: instructions for use

Reviews (analogs are not always able to act as effectively as this medication) note that tablets rarely cause side effects. Take the drug only orally, once a day, regardless of eating, squeezed a little water.

With depression and obsessive-compulsive disorders begin treatment with 50 mg per day. If panic disorder occurs , there is a social phobia and a post-traumatic state of stress, then the therapy starts with 25 mg per day. After a week, the dosage is increased to 50 mg per day. This use of the drug can reduce the occurrence of side effects at the first stage of treatment.

The dosage is selected with a gradual weekly increase. If treatment at a rate of 50 mg per day did not give any result, then the dose is increased by another 50 mg, but not more often than once a week. The maximum daily dosage is 200 mg per day.
During the week, the first results of treatment appear, but the full effect can be achieved after 2-4 weeks of continuous therapy. With obsessive-compulsive disorders, we allow more long-term use of the drug.

With maintenance treatment, the dosage should be minimally effective. In this case, it is adjusted depending on the therapeutic effect. If there is a prolonged depression, then the drug takes at least six months.
It is necessary to constantly monitor the patient's condition during panic and obsessive-compulsive disorders. In this situation, the prevention of recurrence is not carried out.

Serenata tablets (instructions for use inform you of conditions in which this drug can not be used) is allowed to be used to treat obsessive-compulsive disorders in children from six years of age.

Adolescents, in the age category of thirteen to seventeen, are given an initial dosage of 50 mg per day. The initial dose for children from six to twelve years is 25 mg per day. After seven days of administration, the dosage can be increased to 50 mg. In the future, if therapy does not work, the amount of the drug is increased by another 50 mg. Increase dosage is carried out once every few weeks. The maximum allowable amount of the drug is 200 mg per day. The dose is changed no more than once in seven days.

When treating patients of the age group from six to eighteen years old, one should pay attention to body weight, in order to avoid overdose symptoms.

The drug "Serenata" instruction for use does not recommend taking patients with impaired hepatic organ function. Patients with renal insufficiency require dose adjustment.

Do not abruptly stop taking pills. If it is necessary to stop therapy, then it should be done gradually, for fourteen days. Only in this case the probability of occurrence of the withdrawal syndrome will be reduced to a minimum. If you have withdrawal symptoms, you need to see a doctor for the appropriate treatment.

Negative reactions of the body

Warns that with prolonged use may cause negative reactions of the body preparation "Serenata", instructions for use. Analogues in this case are able to replace said drug.

Among the side effects of the gastrointestinal apparatus may be the occurrence of dry mouth. There was a decrease in appetite, which in a few cases led to anorexia. Among the negative reactions, there were dyspeptic disorders, including meteorism, a vomiting reflex, nausea, diarrhea, and abdominal pain.

In some cases, prolonged use of tablets recorded increased activity of transaminases in the blood. After the withdrawal of the drug, this indicator comes back to normal.

On the part of the nervous system, patients were disturbed by drowsiness, dizziness, headache, tremors of extremities. Patients complained of insomnia, agitation, the emergence of a sense of anxiety, hypomania, a violation of coordination of movement and gait unsteadiness. Some felt weakness, extrapyramidal disorders.

There was dyskinesia, convulsions in the muscle tissue, a malfunction in the work of the visual apparatus. Similar disorders were most often seen in patients who had the aforementioned pathologies in history or acquired them because of the simultaneous use of antipsychotic drugs.

When taking the drug, there were failures in the endocrine system. They were expressed in the disorder of ejaculation, a decrease in sexual desire, violation of menstruation, galactorrhea and hyperprolactinaemia.

In some cases, the drug "Serenata" (antidepressant) caused increased sweating. Sometimes due to its effect on the body there was a loss of weight, which in a few cases passed into anorexia. There are people who, during treatment, were troubled by transient hyponatremia.

Among the dermatological symptoms, reddening of the skin, rashes, itching are noted. In rare cases, erythema multiforme was observed.

special instructions

Informs that the medication "Serenata" is not prescribed for two weeks after the abolition of MAO inhibitors, instructions for use (the reviews note that the drug will help survive depression and relieve anxiety). At the same time, MAO inhibitors are not recommended for use within fourteen days after discontinuation of sertraline therapy. There are not enough studies on the use of the drug in patients undergoing electroconvulsive therapy.

It is believed that patients who are depressed, can always resort to suicide. Such a risk remains until a complete remission is achieved. Therefore, at the time of depression, the patient must be closely monitored by medical personnel.

Special care should be taken in the complex use of the "Serenata" tablets and medications that act depressingly on the central nervous system. In this situation, the patient should be monitored.

During Serenata therapy, it should be remembered that simultaneous administration of this drug with any MAO inhibitor can lead to the most severe consequences and cause the progression of various complications, including serotonin syndrome.

Similar negative reactions of the body in a few cases were fatal, occurred with the use of MAO inhibitors during the passage of antidepressant therapy, which inhibit the neuronal capture of monoamines. Side effects also appear after the abolition of these drugs.

From the complex use of selective inhibitors that perform neuronal reuptake of serotonin, rigidity, excessive irritability, hyperthermia, myoclonus, changes in mental status, confusion of thoughts, agitation may develop. The combination of sertraline and coumarin causes an increase in the prothrombin period. Particular attention when taking the drug should be given to children from six years of age.

Warns that it is strictly forbidden to drink alcohol when using the drug "Serenata", the instruction (reviews note that the tablets can adversely affect vision).

When sertraline is used, there are no breakdowns in the functioning of psychomotor functions. Despite this, sharing together with other medications can cause a violation of concentration and failure in coordination of movements. Because of this, during the Serenata therapy, it is not recommended to drive transport and engage in activities that require increased concentration of attention.

Cost of medicinal product

You can buy a tablet of "Serenata" (antidepressant) in almost every pharmacy on prescription. The patients' comments indicate that the drug is capable of causing headache and insomnia, as well as disturbances in the work of the gastrointestinal tract. The cost of 30 tablets of 50 mg - 600 rubles. The price of 30 tablets of 100 mg fluctuates around one thousand rubles.

The drug "Serenata": analogues

If the medicine for some reason did not fit, then the doctor prescribes analogues instead. The most common structural substitutes are:

• Zoloft;
• "Stimuloton";
• "Deprefult";
• "Aleval";
• "Lustral";
• "Asentra";
• "Sirleft";
• Torin;
• "Mistral";
• "Misol";
• "Seralin";
• Zalox;
• "Sertiva";
• Zosert.

These and other drugs are able to replace the drug "Serenata". Analogues should not be selected independently, without consulting a doctor, since such an approach can damage health and cause a number of side effects.

Patients' feedback on tablets

The drug "Serenata" (antidepressant), buyers' reviews caused a variety of. Some patients are completely satisfied with the effect of this drug. It is said that the effect after its application is observed already on the first day of treatment, and by the end of the week the result becomes more pronounced. They note that the medication is a mild antidepressant. It raises mood, gives calmness and awakens cravings for life. After its use, depression, anxiety, fear and suspiciousness go away.

The medicine helps to cure a light neurosis. Removes panic. Patients note that the tablets are well tolerated and rarely cause negative symptoms. They can be drunk for an extended period, but under the supervision of a doctor. The drug significantly improves mood, helps to cope with depression. Removes fear, panic. It helps to feel the craving for life.

But the medicine "Serenata" does not always give the expected result. The reviews of these people mark a complete loss of appetite, headache, sleep disturbance. Some patients note that the drug has a negative impact on the eyesight. It can cause confusion of thoughts and impaired coordination of movement. Some patients had suicidal thoughts. There are people who, after using these pills, complained of increased depression, anxiety. It was noted that the drug is capable of creating internal discomfort.

Doctors quite often use this tool in their practice. From their words, this medicine belongs to disinhibitory antidepressants. It can aggravate anxiety and aggravate the condition with anxious depression. In the latter case, doctors are advised to give preference to antidepressants that have a sedative effect. They remind their patients that the selection of an antidepressant is carried out for each patient individually, and that which helped one can turn out to be useless for the other.