Preparation "Tiamazol": instructions for use

What do you know about a preparation such as Tiamazole? Instructions for use, price, reviews, analogues and purpose of this medication will be provided below.

Form of the drug, its composition and description

What is Tiamazol? The instruction, the description reads, that this agent is made in the form of round tablets covered with a white or yellowish sheath. The composition of this drug includes the eponymous active ingredient - thiamazole, as well as other auxiliary substances.

One can not help saying that this component is found in many other drugs that have similar properties.

Action of the pharmaceutical agent

What is Tiamazol? Instructions for use asserts that this antithyroid agent, which is capable of disrupting the synthesis of thyroid hormones, reduces the internal secretion of T4, and also blocks an enzyme such as peroxidase, which is involved in iodination of thyronine with the formation of diiodothyronine and monoiodothyronine.

It should also be noted that the active substance of this drug significantly speeds up the removal of iodides from the thyroid gland, reduces basal metabolism, increases the secretion and reciprocal activation of the synthesis by the pituitary gland TSH.

The therapeutic effect after the application of this drug depends on the initial concentration of T4 and T3. But as a rule, the concentration of hormones in the human body is normalized after seven weeks after constant intake of the drug at a dosage of 30 mg or 28 days with 40 mg of the drug.

After the lapse of five days after the drug has been discontinued, the concentration of hormones can again increase.

Indications for prescription of tablets

What is the purpose of using the drug "Tiamazol"? Instructions for use inform that this drug is intended for the treatment of thyrotoxicosis (diffuse string). It is also often used in the preoperative period for the purpose of intermediate and preliminary therapy (in addition to radioiodine therapy). In addition, this medication can be prescribed for nodular goiter and relapse (postoperative) thyrotoxicosis.

Prohibitions for appointment

In what cases can not use the drug "Tiamazol"? The instruction for use states that contraindications for this drug are the following conditions:

• High sensitivity to components;
• Period of feeding;
• Expressed granulocytopenia or leukopenia (including in the history).

One can not help saying that with caution this medication is used during pregnancy, with liver failure and large goiter, especially with narrowing of the trachea (it is allowed only as a short-term treatment during the preparation for surgical intervention).

"Tiamazol" medication: instructions for use

The composition of this drug was presented above.

How should the drug be properly used? It is prescribed only inward. The daily dosage of the drug is usually divided into 2 or 3 doses.

At the very beginning of the treatment, one-off dosages of the drug are used at a strictly prescribed time. As for the maintenance dose of the drug, it must be taken in one step, immediately after breakfast.

Adult people with thyrotoxicosis therapy, this medication is prescribed in an amount of 20-40 mg per day. With the euthyroid status, this dosage is gradually reduced to a maintenance dose of 5-20 mg per day (for 3-7 weeks). This drug is continued for 1-1,5 years.

Pregnant women are prescribed medication in minimal doses, that is, 2.5-10 mg.

Adverse events

What kind of reaction of an undesirable character can cause Tiamazol? Instructions for use indicate the following negative effects:

• Fever, nausea, severe weakness, vomiting, agranulocytosis, epigastric pain, granulocytopenia;
• Abnormal liver function, aplastic anemia, hepatitis, paresthesia, cholestatic jaundice;
• Thrombocytopenia, dizziness, hypoprothrombinemia, headache, skin itching, neuritis, urticaria, polyneuritis, rash, taste disorder;
• Pain in the joints, autoimmune insulin syndrome, periarteritis, muscle pain, edema, generalized lymphadenopathy, skin hyperpigmentation, sialadenopathy, lupus-like syndrome, alopecia, weight gain, nephritis, clinical and subclinical hypothyroidism.

Cost, reviews, analogues

Now you know what "Tiamazol" is. Instructions for use, the price of this medication is presented in this article.

Replace the drug in question by such means as "Timidazole", "Antioxidant", "Dananthizol", "Basolan", "Favistan", "Mercazolil", "Mercazol", "Metimazol", "Tarazol", "Methotirin", "Tikapzol "And other.

The cost of Tiamazol is about 150-180 rubles.

Reviews about this medicine are mostly positive. Patients claim that this drug manifests itself as a highly effective antithyroid agent. Its regular application positively affects the course of the disease, such as thyrotoxicosis. In addition, this remedy is often used as an additional preparation for radioiodine therapy. It also manifests itself well in nodular goiter.

The negative sides of this drug include the presence of many side effects.