"Pentamine" is a drug that belongs to the group of H-holinolitikov (ganglioblokatorov). He is on the list of drugs used to stop hypertension.
Mechanism of action
It blocks the receptors of the nodes of the sympathetic and parasympathetic nervous system, depresses the functions of the adrenal glands, and thus reduces systemic pressure. In large quantities, it can have a negative effect on skeletal muscle and CNS. Has hypotensive effect, causes expansion of venules and arterioles, but with tachycardia, impaired focus, dilated pupil, dilated bronchi and decreased motility of the gastrointestinal tract and gland secretion.
The main indication for the use of the drug "Pentamine" instructions for use indicates hypertensive disease of the first and second stage, frequent hypertensive crises. But it can also be used with cerebral edema, atherosclerosis, asthma, eclampsia of pregnant women, gastric and duodenal ulcers and other nosological forms accompanied by increased pressure.
Mode of application
In order to correctly prescribe a drug such as "Pentamine", you need to know the rules of application. The route of administration is intravenous or intramuscular. Usually take a five-percent solution and injections are made 2 milliliters two to three times a day. If the condition is critical and quick help is needed, then 0.2 or 0.5 milliliters of a 5 per cent solution diluted in 20 milliliters of a sterile solution for injection or a 5 per cent solution of glucose is directly injected into the vein . Enter slowly, so that the pressure does not fall too fast and the brainstem has not wedged in.
Also, "Pentamn" (the instruction on the application does on this accent) is used to create artificial hypotension during operations on the cardiac muscle. Thus in a vein under the control of pressure enter up to one and a half milliliters of a five-percentage solution, if necessary increasing it in two, and even three times.
The largest single dose is 3 milliliters, and the daily dose is 9 milliliters.
Considering which strong Pentamtin drug, the instructions for use indicate the possible ailments that it causes. After taking a person can feel dryness in the mouth, weakness, lethargy, dizziness, palpitations. Ocular symptoms, such as a disorder of accommodation, injection of vessels of the sclera and dilated pupil, are also present. There may be a violation of intestinal motility.
As usual, in the first place are allergic reactions to the drug as the most life-threatening condition. This is especially true for people who constantly take "Pentamn". Instructions for use indicate that in addition to hypersensitivity, it is worthwhile to fear the states of shock, acute myocardial infarction, angle-closure glaucoma, chronic hepatic or renal insufficiency. With care to prescribe to people who have an atony of intestinal and / or urinary bladder, thromboses and thrombophlebitis, degenerative diseases of the central nervous system, bronchial asthma. A separate item is old age, which in itself represents a risk factor for developing all of the above contraindications.
Form of issue
In pharmacies is found in the form of a five-percent solution for injection "Pentamine". Instructions for use in ampoules have been described above. Each ampoule contains 1 milliliter of the substance, therefore, when calculating the dose, it is necessary to take into account how many packages of the drug are needed.
Price of issue
At the moment, finding it in the pharmacy network is quite problematic, this cost may be slightly overestimated. It ranges from 700 to 2000 rubles per package. In addition, there are many generics (similar to the active substance of drugs), able to replace "Pentamn". Instructions for use, the price in which is usually not indicated, contains a list of substitute drugs, but before you switch to another medicine, consult your doctor. Perhaps he will find another way out.
To avoid orthostatic collapse, you must clearly adhere to the recommendations left to you by your doctor. After the injection of the drug within the next hour or two, you must be in a prone position to avoid a sharp drop in pressure and fainting. The most acceptable option is titration of the dose. It is necessary to start with a half of the standard calculated dose for an average person with a mass of seventy kilograms. It is important to remember that the higher the initial arterial pressure, the more it decreases even at the same doses of the drug, so you need to take less of it in one injection.
The pharmacist is obliged to warn the buyer that after opening the package it should be stored in the dark place and do not leave the ampoule open for a long time, since the drug "Pentamtin" is a solution. Instructions for use, feedback and expert advice are freely available also on the official website of the manufacturer, but still you should not self-medicate. Remember that health is the highest value of a person, and before attempting to get into the internal homeostasis of an organism, it is worth consulting with the attending physician. It is possible that you do not need such radical methods of pressure correction.