Nurofen plus

Coping migraine attacks can be made using a variety of means. These include nonsteroidal anti-inflammatory drugs, non-opioid analgesics, opioid analgesics, antiemetics and others.

Most often, non-steroidal anti-inflammatory drugs are used in practice . This group of medicines includes Nurofen Plus. The formulation includes codeine phosphate and ibuprofen. These components are well known and have long been used in medical practice.

Ibuprofen helps inhibit the synthesis of prostaglandins. This, in turn, increases the sensitivity threshold for receptor pain in nerve afferent fibers. According to a number of studies, ibuprofen also promotes the inhibition of leukocytes from the bloodstream into damaged tissues. Thus, neurogenic inflammation is suppressed.

Codeine has a centralized effect. It promotes a weak connection of opioid receptors. Codeine can be rapidly absorbed from the digestive tract and metabolized significantly in the liver.

Nurofen plus has an effect on the central and peripheral links of the migraine course. According to a number of experts, the effect of the drug exceeds the effect of taking ibuprofen alone. This is due to the two-component composition of the drug "Nurofen plus" and a wider range of its action.

The medication is actively used to eliminate the symptoms of respiratory diseases. Nurofen plus has antitussive, antipyretic and analgesic effects. The analgesic activity of the drug is associated with the activation of opiate receptors of various calves of the central nervous system and in peripheral tissues. Thus, stimulation of the antinociceptin system occurs and a change in the perception of pain at the emotional level.

Nurofen plus is used to eliminate the pain syndrome of medium and mild severity. This includes toothache, migraine, myalgia, algodismenorea, headache, neuralgia, rheumatic pain. To the testimony include febrile syndromes of different genesis.

Nurofen plus is not prescribed for hypersensitivity to its components, erosion and ulcerative lesions of the digestive tract in the period of exacerbation, respiratory failure, craniocerebral trauma, intracranial hypertension. The drug is not recommended during the antenatal period, children up to twelve years of age, with breastfeeding. Contraindications are hepatic or renal insufficiency.

Adverse events associated with medication include dyspepsia (including constipation and nausea), epigastric pain, violations of liver or kidney function, exacerbation of gastrointestinal disorders, increased pain, drowsiness, bronchospasm, weakness, bradycardia. There is (depending on the uncontrolled and long-term administration of the drug "Nurofen plus") dependence (opioid).

Overdose of the drug manifests itself in stomach pain, vomiting, narrowing of the pupil, bradycardia. When symptoms develop, immediate gastric lavage, naloxone (opioid antagonist), and symptomatic therapy are necessary.

The dosage of the drug is one to two tablets every four to six hours. However, the daily dose does not exceed six tablets. In the absence of the effect of treatment after two or three days, a medical examination is necessary.

Long-term use of medication should be carried out under the constant supervision of a specialist. It requires control over the picture of peripheral blood and liver. The treatment period involves the exclusion of occupations by hazardous activities, which require increased concentration and speed of psychomotor reactions, including driving and handling mechanisms.