Nadroparin Calcium: instructions, indications, side effects

In what form is the preparation Nadroparin Calcium produced? The form of release of this medication is presented in this article. Also, it contains information about the features of the aforementioned drug, its indications and side effects.

Form, composition

"Nadroparin Calcium" is a solution intended for administration under the skin. The preparation in question is a clear, light yellow or colorless, slightly opalescent drug. Its active component is the same substance - calcium supraparin. Also the composition of this medicine includes the following additional ingredients: water d /, calcium hydroxide solution or hydrochloric acid (diluted).

Nadroparin calcium is sold in single-dose syringes, which are packed in blisters and paper packs.

Properties of the medicine

"Nadroparin Calcium" is an antithrombotic and anticoagulant. According to the instructions, this drug is a low molecular weight heparin, which was produced from standard heparin by depolymerization. It has a high tropicity to the protein of the blood antithrombin 3 and well suppresses factor Xa.

One can not help saying that the drug under consideration changes the rheological indexes of blood, that is, it reduces its viscosity, increases the permeability of membranes of granulocyte cells and platelets, and also prevents the development of a pathological process, such as blockage of blood vessels.

Compared with unfractionated heparin, this solution has a weaker effect on platelet activity, primary hemostasis and aggregation.

Kinetics of the agent

What is the kinetic ability of the drug "Nadroparin Calcium"? After subcutaneous administration, the highest anti-Xa activity of this agent is observed after 5 hours. At the same time, its half-life is 2 hours. This drug is metabolized in the liver by depolymerization and desulphation.

Administration of the medicinal product

Occlusion of veins can occur for various reasons. To prevent the development of such a pathological and rather dangerous process, very many doctors prescribe to their patients the drug "Fraksiparin", an active component of which is calcium supra-paryrin. Thus, the said agent is indicated for use:

• In the treatment of thromboembolism;
• For prophylaxis of thromboembolic complications (for example, during orthopedic and surgical interventions, in people with a high risk of thrombosis, including with cardiac or respiratory failure);

• In the treatment of myocardial infarction and unstable angina;
• For prevention of blood clotting

Prohibitions for appointment

Clogging of blood vessels is a rather dangerous phenomenon. However, even with this condition, the drug "Fraksiparin" is not always prescribed to patients. According to experts, this medicine has the following contraindications:

• Intracranial hemorrhage;
• Thrombocytopenia with the use of nadroparin;
• Organic lesions of internal organs with a tendency to bleeding;
• Symptoms or a high risk of bleeding, which is associated with a violation of hemostasis;
• Surgical interventions and traumas of the brain, spinal cord, and also visual organs;
• Septic endocarditis acute;
• Underage age;
• Severe renal insufficiency;
• High sensitivity to supraparin.

Careful use

With caution, the drug "Fraksiparin" is prescribed only in cases associated with a high risk of bleeding, including when:

• Renal failure;
• Arterial hypertension severe;
• In the postoperative period;
• Hepatic insufficiency;
• In people with a body weight of less than 40 kg;
• Peptic ulcers;
• Circulatory disorders in the retina of the eye or choroid;
• In combination with drugs that increase the risk of bleeding.

The drug Nadroparin Calcium: instructions for use

According to the instructions, the agent should be administered subcutaneously to the abdomen (alternately in the left and right side). Thus the patient should be in a lying position. It is also allowed to inject into the thigh.

The dosage of this product is selected only by a doctor, depending on the available indications. For example, in order to prevent thromboembolism, a dose of "Fraksiparin" equal to 0.3 ml is used in surgical practice. In this case, the drug is administered 4 hours before the planned operation, and then - once a day.

The duration of treatment with this drug also depends on the existing disease (usually 6 days).

Side Effects

The use of the drug in question can cause a number of negative effects, in particular:

• Bleeding of different locations;
• Increase in the content of liver enzymes;
• Thrombocytopenia and eosinophilia;
• Hypersensitivity reactions;
• Local reactions such as the appearance of subcutaneous hematoma at the injection site, the formation of solid cones disappearing after a few days, necrosis of the skin in the area of administration;
• Hyperkalaemia and priapism.

Reviews

Occlusion can occur in any person. Therefore, people with impaired circulation often appoint the drug "Fraksiparin" or the so-called "Nadroparin Calcium". Patients argue that this remedy copes well with its direct task. However, it should be noted that this medication often causes the development of negative reactions. In this case, experts recommend replacing it with a safer drug.