HealthPreparations

'Milgamma' - instructions for use.

Dosage form

The drug "Milgamma" is released in solutions for intramuscular injection. A solution of red color, clear, a different color of the solution suggests that this drug is not "Milgamma". Instruction for use contains all information about the preparation.

The composition of the drug is (the amount of substance is indicated per 1 ml of the drug)

  • Thiamine (vit B1) 50 mg
  • Cyanocobalamin hydrochloride (vit B12) - 500 μg
  • Pyridoxine hydrochloride (vit B6) - 50 mg
  • Lidocaine hydrochloride - 10 mg

In addition, the following auxiliary substances can be used: distilled water, sodium hydroxide, benzyl alcohol, potassium hexacyanoferrate, sodium polyphosphate.

Pharmacological action of the drug "Milgamma"

Instructions for the use of the drug standard contains a more detailed description of the pharmacological effect. "Milgamma" consists of a complex of B vitamins that have a positive effect on degenerative and inflammatory nerve diseases. In addition, this vitamin complex favors increased blood flow and improves the functioning of the nervous system as a whole.

Thiamine plays a major role in the metabolism of carbohydrates and in the cycle of tricarboxylic acids, and also participates in the synthesis of adenosine triphosphate and thiamin pyrophosphate.

Pyridoxine is involved in the synthesis of protein, as well as in the metabolism of fats and carbohydrates.

One of the physiological functions of these vitamins is the intensification of each other's action, which manifests itself in the influence on the cardiovascular and neuromuscular systems. With a deficiency of pyridoxine, the vitamin deficiency can be stopped after the administration of this complex.

Cyanocobalamin stimulates hematopoiesis, participates in the creation of the myelin sheath, reduces pain that is associated with damage to the peripheral parts of the nervous system, and can also stimulate nucleic acid metabolism by activating folic acid.

Pharmacokinetics

Pharmacokinetics of the drug "Milgamma" instruction for use contains an abbreviated form. Thiamin is absorbed fairly quickly after intramuscular injection and immediately enters the bloodstream - after 15 minutes the concentration in the blood is 484 ng / ml, if 1 ml of the drug was administered and on the first day of administration.

Pyridoxine after intramuscular injection is absorbed rather quickly into the systemic circulation, while it plays the role of coenzyme, as a result of phosphorylation of the methanol group in the 5th position.

Indications

"Milgamma," the use of which is indicated by a neurological patient, is indicated in the following diseases and syndromes of the nervous system:

  • Paresis of the facial nerve
  • Hannionites
  • Retrobulbar neuritis
  • Flexopathy
  • Polyneuropathy
  • Neuropathy
  • Night cramps
  • Radiculopathy
  • Neurological complications of osteochondrosis
  • Muscle-Toxic Syndromes
  • Sciatica

All these diseases are an indication for the use of the drug "Milgamma." Instructions for use, which should be injected intramuscularly, contains the recommended dosage.

Side effects

When using the drug may cause allergic reactions:

  • Hives
  • Labored breathing
  • Anaphylactic shock
  • Itching
  • Edema Quincke

And other side effects

  • Tachycardia
  • Increased sweating
  • Acne

Contraindications

Contraindications to the use of this drug is:

  • Childhood
  • Pregnancy and lactemia
  • Heart failure
  • Hypersensitivity to any components of the drug

Overdose

An overdose of the drug gives the following symptoms:

  • Arrhythmia
  • Dizziness
  • Convulsions

Treatment of overdose should be symptomatic.

Drug Interactions

Incompatible with solutions that contain sulfites, because thiamine is completely destroyed by contact with them.

In the presence of a complex of vitamins B, other vitamins are most likely inactivated.

Levodopa can reduce the effect of pyridoxine.

To reduce the effectiveness of pyridoxine may result in interaction with epinephrine, cycloserine, D-penicilamine, sulfonamides and norepinephrine.

Thiamin is incompatible with mercuric chloride, oxidizing substances, iodide, acetate, carbonate, tannic acid, phenobarbital, benzylpenicillin, riboflavin, metabisulphite and dextrose.

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