"Midokalm": what helps, the description of the drug, contraindications

What is Medocalm? What helps this tool? The indications and features of the medication under consideration will be presented below. Also, you will learn how to treat this drug, how much it costs and what its composition is.

Pharmaceutical form, package, description, composition

In what form does the medication "Midokalm" come in (what helps this medicine, we will tell below)? This product is available in tablets, as well as in a solution intended for parenteral administration.

Round and white tablets "Midokalm", the price of which is indicated below, consist of tolperisone hydrochloride. As additional ingredients in the composition of the drug in question are: anhydrous colloidal silicone, citric acid monohydrate, corn starch, stearin, hydroxypropylmethylcellulose 2910, talc, macrogol 6000, microcrystalline cellulose, dye, lactose monohydrate and titanium dioxide.

It is produced in blisters, which are placed in boxes of paper.

Transparent solution of "Midokalm" in ampoules also contains tolperisone hydrochloride and lidocaine. In addition, this drug includes the following constituents: talc, citric acid monohydrate, lactose monohydrate, colloidal anhydrous silicone, macrogol 6000, microcrystalline cellulose, stearin, titanium dioxide, corn starch, black iron oxide, hydroxypropyl methylcellulose 2910, red iron oxide and yellow Iron oxide.

The drug "Midokalm" in ampoules is contained in plastic containers, which are placed in boxes of cardboard.

Basic properties

What is "Midokalm"? What helps with this drug? According to the instructions, the agent in question refers to the muscle relaxants of the aminoketone group, which has a central effect.

The effectiveness of this drug is associated with the regulation of the part (caudal) of the reticular formation. The use of this medication promotes suppression of increased reflex excitability of the spinal cord. It also affects the nerve endings (peripheral).

Features of the medicine

The drug "Midokalm" (compatibility of this drug with others is permissible, but under special conditions) is an H-anticholinergic. Its active substance has a stabilizing effect on membranes in primary fibers (afferent), as well as motor neurons. This effect of the drug is due to its ability to influence the reflex work of the spinal synapses.

It should also be noted that this drug again slows the excretion of mediators. This is due to the inhibition of the process of calcium intake into the synaptic structures that are in the nerve fibers.

The effect of this agent on the reticulospinal path is particularly pronounced when the excitation processes slow down. Likewise, local anesthetic action of the drug is revealed (due to the content of lidocaine in it).

Kinetics of medicament

The agent is well absorbed from the intestine. Its concentration (maximum) in the blood is reached after 65 minutes after ingestion. Metabolism of the drug occurs in the kidneys and liver. Derivatives of tolperisone are excreted together with urine.

The repeated course of "Midokalma" has no effect on the work of the kidneys and liver, as well as on the process of hematopoiesis.

This drug reduces experimentally caused rigidity and hypertension of muscle tissue. The therapeutic properties of this drug are actively used to reduce the rigidity of muscles and pathological hypertonia, which is associated with extrapyramidal disorders.

It should also be noted that this drug promotes the activity of a person (his movements). In addition, it has no effect on the cerebral cortex, fully maintaining the level of the patient's wakefulness.

According to the instructions, treatment with "Midokalm" causes slightly expressed spasmolytic and adrenoblocking effects. Thanks to this, tissue perfusion improves.

In the process of conducting long-term clinical studies, this drug has not had a significant effect on hematopoiesis and kidney function.

The drug "Midokalm": from what helps?

This tool is indicated for use in the following cases:

• In pediatric practice with the aim of treating Little's disease (ie spastic paralysis). In addition, this drug is used with encephalopathy of another origin with the phenomena of muscular dystonia.
• In conditions that are accompanied by pathological hypertension of striated muscle tissues developing due to pathologies (neurological) organic origin (for example, with multiple sclerosis, encephalomyelitis, myelopathy, residual phenomena of acute cerebrovascular disorders, pyramidal pathway lesions).
• In conditions that have arisen as a result of damage to the innervation of blood vessels (eg, in acrocyanosis, angioedema, intermittent nature).
• With muscular hypertension, contracture of muscles that accompany diseases of the organs of motion (for example, spondylosis, arthrosis of the elbows, knee and hip joints, spondylarthrosis, lumbar and cervical syndromes).
• With post-thrombotic disorders of venous blood flow and lymphodynamics.
• As a restorative postoperative treatment in orthopedic and traumatological practice.
• With trophic ulcers formed on the lower limbs, angiopathy (including diabetogenic), obliterating angiosclerosis and thromboangiitis, as well as autoimmune diseases (with Raynaud's disease and systemic scleroderma).

Prohibitions to use

In what cases, can not be prescribed pills and injections of "Midokalm"? The use of this medication is contraindicated when:

• Myasthenia gravis;
• Hypersensitivity to tolperisone and a known allergy to lidocaine;
• At the age of up to three months (in tablet form up to one year).

Mode of application

The scheme of application of this tool is set by the doctor depending on the course of the disease, as well as the tolerability of the drug.

For adults, the medication is prescribed in an amount of 150-450 mg (daily dose) in three divided doses. The starting dosage of this medication is 50 mg three times a day. With insufficient efficiency, it is increased.

For intramuscular injections, the drug is used in an amount of 200 mg per day (in two administrations), and intravenous - 100 mg (once a day). In the second case, a very slow infusion of the drug is required.

For children older than three months (up to 6 years), the dosage of the medication is calculated according to the following scheme: 5-10 mg per kg of body weight (three times a day). For a child of 7-14 years of age, it is recommended to use tablets in a daily dose of 2-4 mg per kg of body (three times a day).

Oral reception "Midokalma" must be combined with eating.

Side effects

Taking the drug with individual hypersensitivity can cause weakness in the muscles, dyspeptic symptoms (nausea, discomfort and vomiting), as well as headaches.

With a rapid intravenous infusion of the solution, a decrease in blood pressure is possible.

With an individual drug intolerance, allergic reactions develop. As a rule, with a decrease in the dose of the drug, side effects occur very quickly.

Drug Interactions

Information on the interaction, which limits the use of the drug in question, is not available. However, it should be noted that tolperisone has an effect on the central nervous system. In this case, the drug does not cause drowsiness, so it can be combined with hypnotics and sedatives, as well as medications containing ethanol.

With the simultaneous reception of "Midokalm" enhances the effect of niflumic acid. If it is necessary to combine such funds, a dose reduction of the latter may be required.

Peripheral muscle relaxants, drugs for general anesthesia and psychotropic drugs, as well as "Clonidine" enhance the effectiveness of tolperisone.

Cost and Feedback

How much does Midokalm cost? The price of this tool is about 185 rubles.

The patients' reviews say that the medication in question is very effective, especially with joint diseases. In addition, this remedy is very helpful in the case of impaired blood circulation in the brain, including those that have arisen after traumatic brain injury.

Among the negative reviews can be identified those in which it says that the drug "Midokalm" is not a panacea. Most often this medicine is used as a supportive treatment.