HealthPreparations

"Methodic": reviews for rheumatoid arthritis, particularities of application and effectiveness

Rheumatoid arthritis is a disease that is in a chronic stage of development. It can not be cured, but it is possible to slow the progression of pathology and to prevent the appearance of complications. In this situation, immunosuppressors are treated. To such is the preparation "Methodic". Reviews for rheumatoid arthritis note that the medicine does not work immediately, but after 2-6 months.

"Methodic": composition, form of release

It is produced in the form of a solution for injection of the drug "Methodic". Reviews for rheumatoid arthritis say that the drug with regular use gradually removes the swelling of the joints. Helps to return to normal life.

The effect of the drug is based on the active component of disodium methotrexate. Secondary ingredients are distilled water, as well as sodium chloride and hydroxide.

The drug is produced in a hermetically sealed syringe, intended for injection. In a syringe there can be 7.5-25 mg of an injection solution. In a cardboard box is:

  • Glass syringe;
  • Plastic nozzle;
  • A needle packed in a special blister;
  • Instructions for use.

The solution has a shelf life of two years. Produced in Germany.

Pharmacological properties

Refers to immunosuppressants and antimetabolites. The drug "Methodject" (reviews with rheumatoid arthritis indicate that the medication after injection into the body can cause nausea and dizziness). The drug is characterized by an antitumor property. It is a folic acid antagonist. Reduces dihydrofolate reductase, which takes part in the reconstruction of dihydrofolic acid in tetrahydrofolic. The active substance here acts as a carrier of carbon fragments, irreplaceable for the reunion of purine nucleotides, as well as their derivatives.

The drug prevents reparation and DNA synthesis. It inhibits cellular mitosis. Methotrexate has a greater effect on rapidly proliferating cells related to the bone marrow, embryonic tissue, malignant tumors and mucosal epithelium.

The drug is effective in psoriatic and rheumatoid arthritis. In the treatment of these diseases, the drug exhibits immunosuppressive and anti-inflammatory character. The positive effect of therapy is explained by the increased concentration of adenosine in the inflammatory zone.

Indications for use

Reviews of the "Methodic" indicate the effectiveness of the drug. It is noted that it is well tolerated by patients and rarely causes side effects.

Apply medicine for rheumatoid arthritis and polyarthritis, accompanied by complex juvenile arthritis in a chronic form and actively developing.

Indication for injection is psoriatic arthritis, as well as generalized psoriasis. In the latter case, the "Methodic" is used, if the standard methods of treatment did not work.

Contraindications to use

It is noted that the preparation "Methodject" for rheumatoid arthritis, reviews is excellent. You can not use the medicine in case of violation of the liver, abuse of alcohol-containing drinks, kidney failure, which is in a difficult stage of development.

Do not prescribe medication for bone marrow hypoplasia, severe anemia, leukopenia and thrombocytopenia. Do not inject while infectious pathologies that are chronic and acute. Do not prescribe the drug for ulcerative lesions of the oral cavity and gastrointestinal tract.

Do not use the medicine for severe immunodeficiency, pregnant and lactating women. Treatment with the drug is not carried out simultaneously with the formation of live vaccines. Contraindication to use is hypersensitivity to the constituent elements of the medication.

Use the medicine with caution should people suffering from ascites, GI tract obstruction, dehydration. Under the supervision of a physician, patients with pleural or peritoneal effusions, as well as people with kidney failure, should be present. With caution the agent is used for infectious, fungal, bacterial and parasitic diseases. This includes people suffering from simple and herpes zoster, measles, chicken pox, patients with strongyloidoside and amoebiasis.

Adult patients of childbearing age in the treatment of medication should use reliable contraception. To be protected should be after the end of therapy, for six months. If a woman becomes pregnant during the treatment period, then one must take into account the risk of adverse effects of the drug on the fetus.

Methotrexate penetrates into breast milk and may be dangerous to the baby. When treating "Methodjektom" you should stop breastfeeding your baby for the period of treatment.

Mode of application

Introduced subcutaneously, intravenously and intramuscularly the preparation "Methodic". Instructions for use and reviews recommend using the medication once a week, at one time. The duration of treatment is regulated by the doctor.

For adults with rheumatoid arthritis, the medication is prescribed 7.5 g once a week. The method of administration can be any. You should start with a minimal dose. If it is well tolerated by the patient, the dosage is gradually increased by 2.5 mg per week. The weekly maximum is 25 mg.

The result is observed after 4-8 weeks from the beginning of treatment. After it was possible to remove the symptoms of the disease, the dose is gradually reduced to a minimum. The therapeutic course can last up to ten years or more.

In the treatment of psoriatic arthritis, as well as psoriasis a week before the start of therapy, it is recommended to inject a test dose of 5-10 mg of the solution to detect side effects.

If there are no other prescriptions of the doctor, you should start with 7.5 mg once a week. The dosage is gradually increased. Do not administer more than 25 mg of solution per week. The maximum permissible weekly dose for psoriasis is 30 mg. The result is observed after 2-6 weeks. After achieving the desired effect, the dosage is reduced.

People with renal and hepatic insufficiency, as well as the elderly, should be used with caution.

Children under sixteen with the diagnosis of juvenile arthritis should take the medicine at a rate of 10-15 mg / m 2 from the body surface. The dose can be increased to a maximum standard of 20 mg / m 2 . Children should be given the drug intramuscularly.

To prevent side effects, doctors prescribe folic acid intake the next day after the injection, for the next five days. Before the injection and on the day of the preparation, vitamin B9 can not be drunk.

Drugs with a similar effect

If the "Methodic" for treatment is not approached, then the doctor can replace this drug with another one, similar in composition and action. Common analogues of the "Methodic" include:

  • "Vero-Methotrexate".
  • "Zexat".
  • "Meteorite."
  • "Methotrexate."
  • "Methotrexate-Teva."
  • Treksan.
  • "Trixile".
  • «Эветрекс».

These and other analogs can easily replace the drug, but they must be selected by the attending physician.

Cost

Pay attention to the high cost of the drug "Methodic" reviews. With rheumatoid arthritis (the price for this medicine fluctuates around 600-750 rubles for 0.75-1 ml, 800-1400 rubles can be purchased from 1.5 to 2.5 ml of the drug), it is not necessary to choose especially. The disease requires intensive care. Which, unfortunately, is quite expensive.

Warns that you need to enter weekly "Method" tool instructions for use. Reviews (the price of the above items may vary depending on the pharmacy point) note that the cost of the medication is high enough, but despite this, the medicine gives a good result.

Effectiveness of the drug

They note that the present "savior" in the fight against rheumatoid arthritis is "Methodject", reviews. The effectiveness of the drug has been confirmed by many people.

Injectable administration of the drug allows the drug to be absorbed directly into the blood, bypassing the stomach and intestines. This scheme of application gives greater effectiveness than oral administration of the drug.

"Metodekt" based on methotrexate refers to the basic antirheumatic modifying agents. Has a strong anti-inflammatory property. It can be prescribed at different stages of rheumatoid arthritis. Changes the course of the disease. Used for pain, stiffness and swelling in the joints.

The drug helps many people to live a normal life, to keep working. Slows the development of the disease and the process of damage to the joint and cartilaginous tissue. The effect of the drug is observed after six months.

Reviews of doctors

Very often for the treatment of rheumatoid arthritis doctors are prescribed "Methodic". The doctors' comments point out that it rarely causes side effects and is tolerated well by patients. It is considered one of the best immunosuppressors. Can be used to maintain health constantly, for several years.

The drug is toxic, and therefore when it is used, doctors advise you to follow the injection schedule and dose. Increase and reduce dosage gradually and only under medical supervision. This will prevent possible complications. All women undergoing the treatment with the "Methodject" drug, doctors recommend using reliable contraception, since the drug can adversely affect the fetus.

Reviews about the use in children

Should be used only for the prescription of the doctor preparation "Methodic". Reviews of rheumatoid arthritis in children indicate a positive result, which gives the medicine. In childhood he is prescribed 2 ml once a week. Some guys who used to have problems with joints begin to run after injections, become more active. They manage to achieve a long-term remission and slow the course of the disease.

Babies, who were treated with "Methodic", do not differ from their peers. They play a lot, and the pain in their joints stops worrying them. They have less swelling of limbs, ankles. Improvement does not come immediately, but after 3-4 injections.
Some moms point out that if you do injections before meals, you may experience nausea and dizziness. Medication after eating is tolerated by children better. Despite the effectiveness of the drug, it does not give 100% cure.

Medication "Methodic": reviews for rheumatoid arthritis

Opinions about this drug were mainly positive. Patients say that the remedy prevents the development of the disease, but, when using it, one must constantly be under medical supervision.

The medicine eliminates swelling, pain relieves, but not all pain syndrome passes completely. Some are forced to take additional analgesics. The drug retains its effect throughout the week and if the time is not given an injection, then the symptomatology of the disease can manifest itself again. Relief patients feel after the 5th injection.

There are people who have a reduced dose and cancellation of the drug caused negative consequences. They appeared in the form of poor health, pain, dizziness and nausea. These people note that the dose should be reduced gradually and only after reaching a complete remission.

Still patients complain that the medicine is difficult to get in pharmacies and it is necessary specially to order it. Many people are not happy with the high price of the drug. They note that a patient with rheumatoid arthritis should be given a medication for free, since not everyone can afford to buy it.

In general, for the treatment of severe joint diseases one of the most powerful and modern drugs is the "Methodic". Reviews (with rheumatoid arthritis in children and adults this is especially important) claim that it prevents the development of pathology and helps to achieve a long-term remission.

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