"Indomethacin" (tablets): instructions for use, reviews

One of the representatives of the group of non - steroidal anti - inflammatory drugs is the drug "Indomethacin" (tablets). Thanks to its anti-inflammatory, analgesic and antipyretic effects, it is used to treat inflammatory diseases, eliminate pain, reduce swelling and restore joint mobility.

Description of the preparation

The main active substance of the drug is indomethacin, which is referred to as indoleacetic acid derivatives. Indicated inside the package of medication "Indomethacin" tablets describes as elements with a protective enteric coating that allows the active substance to be released into the intestine, bypassing the stomach. According to the form of the tablet round, biconvex, top covered with a light brown shell.

Tablets are available in several dosages: 25 mg, 50 mg and 100 mg indomethacin. Available in 10 or 40 pieces per pack.

All dosage forms

In addition to tablets, there are other forms of the preparation "Indomethacin" for oral use, for example capsules with a prolonged effect of 75 mg dosage. For rectal administration, suppositories with a dose of 50 mg are used. For external use, an ointment of 5% and 10% and a gel of 3% was created.

Mechanism of action

The drug is a non-steroidal anti-inflammatory agent of systemic action that has anti-inflammatory, anti-edematous, analgesic and antipyretic effects. The instruction attached to the preparation "Indomethacin" (tablets) contains a description of the mechanism of its active component functioning, associated with a decrease in cyclooxygenase activity of type 1 and type 2. In turn, this enzyme has less effect on arachidonic acid, which reduces its transformation into prostaglandins. It is these substances that cause inflammation and pain.

Indomethacin exhibits an antiaggregant effect, reducing the clumping of platelet blood cells. The substance weakens the pain syndrome with joint pain in a calm and mobile state, reduces morning stiffness and swelling, increases the volume of movements. The action of indomethacin is aimed at reducing inflammation. The maximum this effect manifests itself on the seventh day of treatment with tablets of the drug.

What heals

Proceeding from the mechanism of action, the tablet "Indomethacin" instruction for use advises to apply for systemic treatment:

• Articular syndrome;
• Inflammatory diseases of the musculoskeletal system caused by rheumatic, psoriatic, rheumatoid, juvenile arthritis, humerous periarthritis, ankylosing spondylitis, joint damage with deforming osteitis and urethrookulosinovial syndrome;
• Degenerative diseases of the musculoskeletal system caused by osteochondrosis in the root syndrome, deforming osteoarthrosis of the joints, excluding hip and intervertebral arthrosis;
• Diffuse disease, surrounding the connective tissue;
• Rheumatism;
• Suppurative inflammation of the periarticular bag and tendons;
• Acute pain symptom in the lower back and other parts of the spine with sciatic and other nerves neuralgia, muscle inflammation;
• Traumatic inflammation in soft tissues or joints.

With its help you can cope with headache, menstrual, toothache, algodismenosis.

As an aid for infectious inflammatory diseases, such as pharyngitis, tonsillitis, otitis media, the medication Indomethacin (tablets) is used. Indications for use include treatment of cystitis, adnexitis, prostatitis.

The drug is effective for the removal of febrile syndrome associated with lymphogranulomatosis, lymphoma, tumor metastases when paracetamol and acetylsalicylic acid do not work.

How to take

The medication "Indomethacin" in tablets is prescribed to the patient in a given dosage based on the degree of the disease. Usually, adults start taking a dose of 25 mg three times daily after meals.

If the effect of treatment is not enough expressed, the dosage is doubled to 50 mg 3 times a day. The maximum allowable dose should not exceed 200 mg of indomethacin. After a marked improvement caused by drug therapy, treatment is stopped only after 4 weeks, using at that time the previous or reduced dose. If patients take Indomethacin tablets for a long time, the instructions for use recommend a dosage of not more than 75 mg of active ingredient per day.

Treatment of children

For a child, the daily dose is calculated by multiplying 2.5 or 3 mg per body weight, it is taken 3-4 times. For each age category, the use of an initial daily dose is provided:

• Children from 3 to 7 years are prescribed from 50 mg to 75 mg, which corresponds to 2 or 3 tablets;
• Children from 7 to 12 years are prescribed from 75 mg to 100 mg, which corresponds to 3 or 4 tablets;
• Children from 12 years of age are prescribed from 100 mg to 125 mg, which corresponds to 4 or 5 tablets.

In the first few days, you should find out how the medicine works on the baby's body, so use a small dose of medication. The duration of therapy with "Indomethacin" (tablets) is indicated by the instruction as a period of 6 to 7 days.

Reception Features

In connection with the current likelihood of developing unwanted effects from taking "Indomethacin" in tablets, it is best not to use it for the treatment of acute rheumatic fever in childhood. Entering into breast milk, the active substance penetrates the child's blood, strengthens the physiological jaundice of the baby and the damage to the liver cells. To prevent this, breastfeeding is abolished.

Elderly, patients with diseased liver, kidneys, digestive tract, dyspeptic symptoms, high blood pressure, heart failure, after surgery, Parkinson's disease, epilepsy, pregnant women in I and II trimester with the appointment of indomethacin treatment require monitoring of the body. It is necessary to monitor the function of the problem organs, once per 7 days to examine peripheral blood.

If in the past there were allergic reactions to non-steroidal anti-inflammatory drugs, then the medication "Indomethacin" (tablets) is prescribed in extreme cases.

It is not recommended to perform hazardous activities during treatment, as attention and psychomotor activity are impaired.

When you can not take

There are diseases in which the drug "Indomethacin" (tablets) is contraindicated. Its application is impossible:

• With increased sensitivity to indomethacin;
• In the presence of erosive-ulcerative lesions of the digestive system in the acute phase;
• With "aspirin triad", characterized by intolerance to acid acetylsalicylic, polyps in the nose and bronchial asthma;
• With disturbed hematopoiesis;
• With a marked change in the work of the liver and kidneys;
• With salt and fluid retention with possible peripheral edema;
• With a severe form of myocardial insufficiency of a chronic nature;
• At increased pressure;
• With bronchial asthma;
• Inflammation of the pancreas;
• In the third trimester of bearing a child;
• When breastfeeding;
• In childhood to 3 years.

Undesirable reactions

Taking medication "Indomethacin" (pills) can be accompanied by side effects, negatively affecting the condition of the human body. To frequent undesirable reactions include nausea, anorexia, pain in the abdomen, flatulence, constipation, indigestion.

In single cases, side effects may manifest as erosive-ulcerative lesions, bleeding and perforation of the walls of the stomach and intestines; Aplastic or hemolytic anemia, leukopenia, thrombocytopenia, agranulocytosis, rash, hair loss, skin itching, seizures, Quinck's edema, bronchial spasm.

Very rarely there are signs of Lyell syndrome, anaphylactic shock, nodal erythema.

During treatment, it is possible to disrupt the excretory work of the kidneys and liver, which increases the content of bilirubin, hepatic transaminase.

Prolonged use of the drug "Indomethacin" (tablets) does not exclude side reactions associated with sleep disorders, dizziness, peripheral neuropathy, headache, irritation, irritability, fatigue. They are characterized by opacity of the cornea, conjunctivitis, hearing impairment, noise in the ears, increased pressure, edema.

Reviews

It is very important to comply with all rules of the drug, exclude all contraindications.

Ambiguous are with regard to taking the drug "Indomethacin" reviews. Tablets have more side effects than medicinal forms for external use. In addition, this medication refers to inhibitors of cyclooxygenase type 1 and 2, which are considered less effective and cause a number of adverse reactions from the gastrointestinal tract.

Rheumatologists and surgeons often prescribe to their patients more modern medicines from the group of oxicams. They inhibit only type 2 cyclooxygenase, without affecting the type 1 enzyme, which provides the production of prostaglandins protecting the digestive system. That is why oxicams cause less damage to the stomach than the medication "Indomethacin" (tablets). The negative feedback instruction includes a description of the side effects, but this does not mean that in the treatment they all should manifest. It all depends on the characteristics of the body.

Many patients this tool saves from back pain, myalgia, intercostal neuralgia, when other medications do not help. And negative effects practically do not arise from treatment with the drug "Indomethacin". Reviews of the pill from the recovered patients are positive. Although the risk is always present, and only the attending physician can prescribe the administration of such a serious drug.

Analogues

Tablets with the active substance indomethacin are manufactured by many foreign and domestic enterprises, such as the companies Sopharma, Ludwig Mekle, Nycomed, Farmachim, Berlin Hemi Menarini, Altpharm. Only each drug has its own trade name, its composition of auxiliary components. All analogues have the same indications for use, side effects, contraindications.

The most popular drug is "Indomethacin Sopharma" (tablets). It is produced in a dosage of 50 and 100 mg by the company "Sopharma" (Bulgaria). Refers to non-steroidal anti-inflammatory drugs.

Another pair of no less well-known analogues are the medications Indomethacin 50 mg Berlin-Chemie and Indomethacin 100 mg Berlin-Chemie. Produced in two dosages (50 and 100 mg) by the Italian company Berlin-Chemie Menarini.

The preparation "Indomethacin" (tablets) analogs is also of Russian origin. They are produced in different dosage forms. The main analogues are:

• "Indomethacin-Acry" chemical-pharmaceutical plant JSC "Akrihin";
• "Indomethacin-Altpharm", LLC "Altpharm";
• "Indomethacin-Biosynthesis", JSC "Biosintez";
• Vero-Indomethacin, Veropharm.