"Doxycycline" - from what these pills? Instructions for use, feedback

"Doxycycline" - from what these pills? Surely, many patients who were prescribed this medication, worried about this issue. After all, doctors often recommend taking certain medications without explaining why they are needed, how they affect the body, whether they have contraindications and side effects. As a result, the condition of some patients may not improve, but, conversely, worsen.

In connection with all of the above, before taking any medication, we recommend that you clarify with the doctor why he was appointed to you. If you did not receive an intelligible answer, we advise you to carefully study the attached instructions.

So, Doxycycline. What are these pills and whether they have contraindications? These and other questions regarding this drug we will answer in the article presented.

Composition, form, description and packaging of the medicinal product

Before answering the question: "Doxycycline" - what are these tablets from? ", It is necessary to tell what composition this medication has.

The composition of the drug under consideration includes such an active element as doxycycline (this substance in the instructions is presented in the form of doxycycline hiclate). In addition, the drug contains the following additional ingredients: magnesium stearate, lactose monohydrate and potato starch.

The drug "Doxycycline" goes on sale in the form of hard capsules made of gelatin, which have the shape of a cylinder and yellow color. Inside of them there is a yellowish powder with white impregnations.

Very often the form of the drug is called a tablet. Although in fact they are not.

The capsule shell of this agent consists of propyl parahydroxybenzoate, glycerol, methyl parahydroxybenzoate, gelatin, E110 and E104 additives, and sodium lauryl sulfate.

In what packaging is Doxycycline sold? The capsules are placed in the cellular contour packs, which are contained in cardboard boxes.

One can not help saying that this medication is also manufactured in the form of a lyophilizate, which is used to prepare an infusion solution.

The principle of the antibiotic drug "Doxycycline"

What is the drug "Doxycycline"? The instruction (price, drug reviews are presented below) states that this is a semi-synthetic antibiotic agent belonging to a group of antibiotics - tetracyclines, which have a fairly wide range of action.

The drug under consideration is capable of producing bacteriostatic effects. It inhibits the processes of protein synthesis in harmful microorganisms.

Penetrating into the cells, the active substance of the drug immediately affects the pathogens in them. Doxycycline hiclata inhibits the synthesis of proteins in microbial cells, and also disrupts the transport of aminoacyl-RNA.

Features of the medicinal product

With respect to which bacteria is the most effective drug "Doxycycline"? The action (pernicious) of this drug is directed to such Gram-positive microorganisms, as aerobic cocci, aerobic and anaerobic spore-forming, as well as aerobic non-spore-forming bacteria.

Among other things, taking this medication negatively affects the life of such gram-negative microbes, as aerobic cocci and aerobic bacteria.

What is the difference between the antibiotic Doxycycline and Tetracycline? According to reviews of specialists, the last drug to a lesser degree depresses the intestinal microflora. In addition, its absorption is more complete, and the therapeutic effect is long-lasting.

It should also be noted that the antibacterial activity we are considering is much higher in antibacterial activity than in natural tetracyclines. The instruction asserts that the therapeutic efficacy of this drug is manifested when taking even small medicinal doses.

Kinetic parameters of capsules

Is the antibiotic "Doxycycline" absorbed? Absorption in this medicine is very high and fairly fast (about 100%). In this case, eating does not affect the degree of absorption.

The drug dissolves fairly easily in lipids. However, it has a low affinity for the binding of calcium ions.

After taking the medicine in an amount of 200 mg, the time to reach its highest concentration in the blood is 2.5 hours.

The active substance of the antibiotic binds to plasma proteins by 80-95%. It penetrates quite well into tissues and organs. Approximately 45 minutes after oral administration, therapeutic drug concentrations are found in the liver, spleen, kidneys, prostate, lungs, bones, eye tissues, teeth, bile, ascites and pleural fluids, synovial exudate, as well as in gingival fluid, exudate frontal and Maxillary sinuses.

It should also be noted that "Doxycycline" penetrates the spinal cord fluid rather poorly.

Also, the agent in question is defined in breast milk and is found in the placenta.

Metabolism of the antibiotic is carried out in the liver (about 30-55%). Its half-life is 12-16 hours.

With repeated use of the medicine, he can cumulate.

The drug is excreted through the intestines and kidneys. In people with disrupted urinary system, excretion of a drug substance is carried out through gastrointestinal secretion.

The drug "Doxycycline": from what these pills?

There are a lot of indications for taking this medication. Tablets can be taken in the following cases:

• In otolaryngological practice with infections of the ENT organs (tonsillitis, otitis, sinusitis and others);
• In inflammatory and infectious diseases that were caused by sensitive bacteria, as well as with respiratory tract infections (tracheitis, pharyngitis, bronchopneumonia, chronic or acute bronchitis, lung abscess, lobar pneumonia, pleural empyema);
• In gastroenterology with infections of the gastrointestinal tract and bile ducts (gastroenterocolitis, cholecystitis, travelers' diarrhea, bacterial dysentery, cholangitis);
• With infections of soft tissues and skin (infected burns, phlegmon, furunculosis, abscesses, wounds, panaritsia, etc.);
• With infectious diseases of the eyes, yawsinosis, rickettsiosis, legionellosis, chlamydiosis of various localization, proctitis, prostatitis, fever of Ku, typhus (including tick, rash, and recurrent), spotty fever, amoebic and bacillary dysentery, Lyme disease, actinomycosis, Tularemia, cholera, malaria;
• In urology with infections of the genitourinary system (endometritis, cystitis, pyelonephritis, urethrocystitis, urethritis, endocervicitis, urogenital mycoplasmosis, acute orchypididitis, prostatitis, gonorrhea);
• With exacerbation of chronic bronchitis to patients under 65 years of age as a medicine of the "first" series (without concomitant diseases);
• With bronchopulmonary infection (exacerbation) of staphylococcal origin in people with chlamydial arthritis, cystic fibrosis and granulocyte erlichiosis;
• With acute prostatitis and urinary infection in the elderly (caused by Escherichia coli);
• In combination therapy with leptospirosis, ornithosis, trachoma, psittacosis, granulocyte erlichiosis;
• In combined therapy with brucellosis, whooping cough, osteomyelitis, subacute septic endocarditis, sepsis, peritonitis;
• For prophylaxis of suppurative postoperative complications, when traveling on the territory where strains that are resistant to chloroquine, as well as malaria are especially common.

Contraindications of the medicinal product

The drug "Doxycycline" with ureaplasma helps very well. However, using it according to the testimony is not always possible. According to the instructions, this drug is prohibited for use when:

• Deficiency of lactase;
• Hypersensitivity to doxycycline, as well as other drug substances and tetracyclines;
• Lactose intolerance;
• Porphyria;
• Glucose-galactose malabsorption;
• Leukopenia;
• Severe hepatic insufficiency;
• In childhood up to twelve years;
• With a body weight of less than 45 kg.

Method of antibiotic use for adults and children

How should I take the medicine "Doxycycline" (the price of the tablet is listed below)? Antibiotic in capsules should be used after a meal. In this case, the drug should be washed down with a sufficient amount of warm liquid.

The described administration of the drug significantly reduces the likelihood of irritations on the esophageal mucosa.

The dosage recommended by the doctor, which the patient must take, must be divided into 2 divided doses. Use the capsule preferably once every 12 hours.

Doxycycline: Dosage

Typically, doctors prescribe this drug in the following dosage: on the first day - 200 mg, and then on 100-200 mg (depends on the course of the disease).

If a patient has a severe infectious process, then throughout the therapy he is recommended to drink 200 mg of medication a day.

In pathological conditions that were caused by chlamydia, mycoplasma or ureaplasma, the antibiotic is given in a standard dosage. Take this drug is desirable for 11-15 days.

Can I combine Doxycycline with other tablets? The compatibility of this with medication with other drugs is quite real. As a rule, it depends on the type of disease and its current. If required, the antibiotic in question can be combined with "Clindamycin" and "Gentamicin".

Other ways of taking an antibiotic

Capsules "Doxycycline" with a tick bite should be taken only on the advice of a doctor. It is very important to use the medicine for preventive purposes no later than 72 hours after a direct bite.

In acute inflammatory diseases in women, the drug is prescribed in the amount of 100 mg twice a day. Men are recommended to take it either in the same dosage and at the same frequency, or at a dose equal to 300 mg once.

To children after reaching the age of 8, the drug is prescribed in an amount of 4 mg per kg on the first day, and then 2-4 mg per kg per day (depends on the course of the disease).

To prevent infectious complications that may occur during an abortion, use 100 mg of the drug 60 minutes before the procedure and 200 mg after half an hour after.

People with secondary and primary syphilis should take 300 mg of funds per day for 10 days.

The dose of Doxycycline in patients with gonorrhea should be 100 mg twice daily for 2-4 days. Men with gonorrheic urethritis are recommended a single dose of the drug in an amount of 300 mg. If the causative agent is stable, then you can take 200 mg of medication for 4 days (for women - for five days).

Antibiotic in the presence of acne and acne should be used at 50 mg per day. The duration of treatment should be 7-12 weeks.

How to treat borreliosis? "Doxycycline" with this diagnosis is prescribed a course lasting 3-5 days in the amount of 200 mg a day.

Adverse Reactions

Against the background of taking an antibiotic, the patient can experience the following pathological conditions:

• Development of anorexia;
• Vomiting, increased intracranial pressure, headaches, edema of the optic disc, decreased appetite, dizziness, toxic effects on the central nervous system;
• tinnitus;
• Enterocolitis, nausea, gastritis, diarrhea, esophagitis, constipation, dysphagia, abdominal pain, pseudomembranous colitis, glossitis, ulceration of the gastrointestinal tract;
• Maculopapular rash, anaphylactic shock, skin itch, Stevens-Johnson syndrome, skin hyperemia, drug lupus erythematosus, angioedema, urticaria, anaphylactoid reactions, anaphylaxis, erythematous rash, anaphylactoid reactions, exfoliative dermatitis ;
• Diplopia due to increased intracranial pressure, blurred vision, scotoma;
• Reduction of blood pressure, pericarditis, erythema multiforme, tachycardia;
• An increase in liver transaminases, a violation of the liver, cholestasis, autoimmune hepatitis;
• Hemolytic anemia, neutropenia, thrombocytopenia, leukopenia, decreased prothrombin index, eosinophilia;
• Myalgia, arthralgia;
• Photosensitivity, dysbacteriosis, superinfection, inflammation in the anogenital zone, stable discoloration of the teeth, vaginitis, a syndrome similar to serum sickness, glossitis, toxic epidermal necrolysis, proctitis, stomatitis;
• Increase in residual urea nitrogen .

Price and similar means

How much is the drug "Doxycycline"? The price of a tablet (10 pieces) depends on the mark-up of pharmacy chains. As a rule, the cost of such a medicine does not exceed 20-30 rubles.

If it is required to replace it, doctors recommend using the following antibiotic drugs: Doxycycline Ferein, Unidox Solutab, Dovitsil, Doxycycline Hydrochloride, Doxilin, Doxycycline Nicomed, Doxipan, Doxycycline-AKOS .

It should immediately be noted that the cost of all of these funds can be much higher than the one under consideration. Therefore, in the absence of contraindications and side effects, patients prefer to use "Doxycycline".

Reviews about antibiotics

There are not very many reviews of Doxycycline. Those reports that are available are mainly left by patients who used this medication to treat chlamydia, as well as infectious diseases of ENT organs and respiratory organs. Basically, they are positive. This drug is quite effective in the presence of these conditions.

It should also be noted that often about "Doxycycline" leave positive feedback and those patients who used it from acne and acne.

It should also be said that, in addition to positive responses, negative messages are also found about the effect of this drug. As a rule, they are associated with the development of a large number of side effects from the gastrointestinal tract.