"Deprenorm MB 35": instructions, references, analogues

Diseases of the cardiovascular system - one of the most frequent in the world, besides the mortality from them is quite high. A large number of cardiac ailments is accompanied by discomfort and pain. This causes modern pharmacology to develop drugs that can improve the quality of life of patients, prevent the development of the problem and normalize the work of the heart. "Deprenorm" and "Deprenorm MB" at a dosage of 35 mg with prolonged action are drugs that relieve pain in the heart due to the ability to normalize the cardiac muscle metabolism.

Indications for admission

The drug "Deprenorm MB 35 mg" is recommended for the following health problems:

• Ischemia of the heart, ischemic cardiomyopathy.
• Vascular pathologies of vision, hearing, vestibular apparatus.
• Vascular dizziness, Meniere's disease, tinnitus.

When treating ischemic diseases, "Deprenorm MB 35 mg" is used in conjunction with other drugs.

Therapeutic effect

"Depenorm MG 35 mg" contains active active substance trimetazidine. According to the principle of influence, it is similar to such a medicine as "Preductal". Has antianginal, antihypoxic, cytoprotective, metabolic effect. About such a medicine as "Depenorm MG 35 mg", doctors' reviews are often positive. Experts speak of him as an effective and quick-acting medicine. The expected effect is observed on average two weeks after the start of therapy.

Pharmacological action of the drug is to improve the metabolism and function of cardiomyocytes and neurons of the brain. It reduces the degree of damage to the myocardium, enhances aerobic glycolysis and inhibits the oxidation of fatty acids. As a result, the energy potential is increased, oxidative decarboxylation and rationalization of oxygen consumption are activated. Due to the drug, normal contractility of the myocardium is preserved, the depletion of ATP and creatine phosphate in the cells is prevented.

If the patient suffers from acidosis, the drug helps to normalize the ion channels of the membranes and the content of potassium ions inside the cells, does not allow the accumulation of calcium and sodium in cardiomyocytes. Reduces acidosis and phosphate levels in cells.

If the goal is to eliminate angina, then thanks to trimetazidine, the coronary reserve is increased, which is why the development of ischemia, which causes physical stress, slows down. This effect is observed from the beginning of the third week of treatment.

Simply stated, trimetazidine, which is in this drug, has a supporting effect on the heart, it has a beneficial effect on the brain and nervous system, as it protects the nerve cells, normalizes their breathing and energy supply. The myocardium retains the ability to normal reduction, as a result, the patient is less likely to experience angina attacks, blood pressure changes become less pronounced.

Therapy with this drug can reduce the doses of nitrates that the patient takes. The noise in the ears disappears, the indices of the vestibular samples improve, the hearing becomes sharper. Vertigo is less common. Increased stamina and ability to exercise. If the patient suffered from vascular pathology of the eyes, he improves the condition of the retina.

Those who constantly take "Deprenorm MB 35 mg", reviews about the drug as a whole are positive: they note that overall there has been a noticeable improvement.

From the gastrointestinal tract the drug is absorbed completely, the half-life is about 6 hours, it is excreted by the kidneys.

Forms and rules of use

The drug is primarily antianginal. It is available in the form of two-layered round tablets covered with a pink coating.

There are two types of medication: "Deprenorm" and "Deprenorm MB" (with modified release). The first is available in a dosage of 20 mg. The second - in a dosage of 35 mg. Also there is a form of release for 70 mg, but not for all it is convenient, as it is necessary to divide the tablet into two doses, in contrast to the already ready-made single dose - "Depenorm MG 35 mg". The guideline recommends a standard daily dose of 70 mg, which must be taken with meals in two meals (the best time is breakfast and dinner).

Sometimes the dose of the drug can be changed to 70 mg once, that is, two tablets in one session.

Duration of treatment is determined individually depending on the patient's illness, its duration and general condition. Tablets "Deprenorm MB 35 mg" have a prolonged effect.

The medicine is dispensed only on prescription, as it is forbidden to use it without medical supervision. It is especially important to take it as required by the drug "Deprenorm MB 35" instruction. Reviews about this drug almost do not report a negative effect on the patient's condition, there are no problems with overdose, there are almost no side effects from it, but nevertheless, like any other strong cardiac medicine, "Depenorm" should be drunk with caution.

Contraindications

It is necessary to take into account some states of the body when taking such a drug as "Deprenorm MB 35 mg". The instructions for use do not recommend the use of the drug if the patient has serious violations of liver function and renal pathology, including kidney failure, in which the CC is less than 1 ml / min.

It is impossible to carry out therapy if the patient is pregnant or breast-feeding. The medicine negatively affects the fetus and even leads to malformations. When breastfeeding the drug enters the body of the baby with the mother's milk and also has a negative impact on it. "Deprenorm MB" is not prescribed at the age of under 18, because the effectiveness and safety of this drug for children and adolescents (as for the fetus) is not established.

Undesirable therapy is considered a drug if the patient is over 75 years old. If you need to take this particular drug, you should use it with extreme caution.

It is not recommended to take "Deprenorm" if the patient has sensitivity to its components.

The drug should not be used as a remedy for stopping angina attacks. If a patient develops an attack, the cardiologist should change the principle of therapy.

It is worth noting that the reception of "Deprenorm" does not interfere with driving a car and doing works that require special attention, since it does not have a sedative effect, but it must be taken with caution, as it sometimes causes dizziness.

Side effects

Few drugs do not cause side effects, especially for potent drugs, which is the "Deprenorm".

Trimetazidine occasionally can cause reactions from the digestive system - gastralgia, nausea, vomiting. With individual intolerance, it is capable of provoking an allergic skin itch. Patients may complain of a headache, severe heartbeat.

Also, trimetazidine is able, albeit extremely rarely, to cause Parkinson's symptoms or to intensify them. Therefore, patients, especially the elderly, should be observed regularly at the cardiologist. In the case of motor disorders (tremor, tone, instability in the Romberg pose and others), the drug is completely canceled, the symptoms disappear within four months. If they persist, neurologist consultation is required.

However, those who drink tablets containing trimetazidine, as recommended by the "Deprenorm MB 35" instruction, reviews often leave positive. Patients report little or no side effects. In most situations, negative reactions are eliminated by lowering the dose of the drug. In any case, with the appearance of unusual symptoms, the patient must immediately report them to his treating doctor.

Overdose

As for the excess dose of "Deprenorm", it should be noted that at present there is no information about cases of drug overdose. However, it is highly not recommended to take in amounts exceeding those specified.

Interaction with other means

There is no information on the interaction of the drug "Deprenorm MB" with others. But in any case, it is necessary to take into account the intake of other drugs and to inform your doctor about what you are already taking if he prescribes "Depenorm MG 35 mg". The instructions for the use of other medicines may contain information on the interaction with the means for treating ischemic heart diseases. Be sure to study this information, since with the use of two or more drugs, the effect of them may be weakened or intensified. In the first case, there will be no expected result from taking the medication, in the second, an overdose is possible up to poisoning.

Synonyms and Analogues

If the drug "Deprenorm MB" for some reason is not suitable for the patient, it is easy to select analogs with the same active substance. Medication refers to the antianginal. It also helps to get rid of vegetovascular dystonia and ischemic heart disease. Based on the reason for the therapy with the drug "Deprenorm MB", the analogue can be chosen from medications based on trimetazidine. Replacement should appoint only a doctor. He will tell you what information is reported on this account, attached to the drug "Depenorm MB 35" instruction, reviews.

Analogues are represented by the following means:

• "Angiozil Retard."
• "Vero-Trimetazidine."
• "Medarum 20" and "Medarum MB".
• "Preductal" and "Preductal MB".
• "Trimectal" and "Trimectal MB".
• "Trimetazidine" and "Trimetazidine MB";

You can also pay attention to "Angital", "Antisten", "Rimekor", "Tridukard", "Trimet", "Preductal", "Trimetazid", as well as "Trimetazid" manufactured by FPO "Ferrain", "Biocom".

Usually they have the same dosage and are taken in the same way as "Deprenorm MB". They generally have the same contraindications and frequency of side effects. They are also prescribed as an independent drug, if there is enough for this disease, or they are used in complex treatment in combination with other medicines. All products containing trimetazidine are recommended by a doctor, are purchased by prescription and can not be taken uncontrolled. Please note that it is very important to take into account the feedback of only those patients who take this drug strictly according to the rules.

The group of drugs taken with vegetovascular dystonia also includes "Cortexin", "Cardio-Omega", "Doppelgerz VIP", "Ginkgo-biloba". The drugs prescribed for ischemia of the heart include Benzaflavin, Atenolan, Atorvastatin.

Doctor's comments about "Deprenorm"

If the cardiologist has appointed trimetazidine to the patient, then he will be interested not only in the instruction attached to the "Deprenorm MB 35" agent. Reviews are often critical, especially if they are left by doctors about the effectiveness and appropriateness of taking this medication both independently and in complex treatment.

Unfortunately, there is no unambiguous attitude among cardiologists to "Deprenorm". Some of them believe that it can not significantly affect the patient's condition. But most of them still quite often appoint "Deprenorm MB 35 mg". Instructions of doctors' reviews on the whole confirm: the action stated in it is proved by the results, which are obtained due to the drug administration by patients.

And those and others have arguments and evidence of their point of view, so it is worthwhile to know the opinion of patients who took this drug.

Patient Reviews

Many patients are supporters of this drug. They take it and feel the improvement. If you do everything, as recommended by the tool "Deprenorm MB 35" instruction, reviews about it will be positive.

Patients who received the drug for the usual treatment regimen notice that angina happens less and less, pain and dyspnea disturb less, and even visual acuity is improved

But there are consumers who consider the effect of placebo the actions that give "Deprenorm MB 35 mg." Patients' comments indicate that as a result of autosuggestion there is a temporary improvement, but in fact, there is no proven effectiveness.

And yet most patients believe that the meaning of taking this drug is. In addition to the persistent effect, pain reduction and general improvement in health, he has rare side effects, an affordable price, he does not have any noticeable negative effect on his health, but only if the concomitant diseases can be treated with "Deprenorm".

Particular attention is advised to draw on contraindications: many patients began to take "Deprenorm", not taking into account the state of health. As a result, instead of improving, they showed side effects, they began to complain more about health. The withdrawal of the drug and the choice of another method of therapy normalized the condition, but in this case the problem is not in the medicine itself, but in that the patient ignored the contraindications to it.

Patients without contraindications taking this drug, note that with regular admission, blood circulation improves, pressure normalizes. After a long period of discomfort, they generally feel healthy. Many, after they began to be treated with the help of this remedy, noticed that they began to walk easier, missing shortness of breath, palpitation smooth and calm. Some begin to climb the stairs without stopping and resting, doing physical exercises.

Of the significant advantages of this drug, patients note that you can drink it continuously, without interruptions, as long as you please. This reduces the need for other drugs (for example, in nitroglycerin), and even in a stressful situation, the heart continues to work without interruptions and pain. It is especially noted that when switching or switching to "Deprenorm" therapy, the effect of treatment is more noticeable and significant.