The drug 'MIG 400', instructions for use, side effects

"MIG 400" is a non-steroidal anti-inflammatory drug. The active substance ibuprofen is a derivative of propionic acid, has an antipyretic, analgesic, anti-inflammatory effect that occurs with indiscriminate blockade of COX-1 and 2, and an inhibitory effect on the synthesis of prostaglandins.

The action of the drug as an analgesic has nothing to do with the narcotic type, it has the maximum severity in the pain accompanying inflammatory processes. Anti-aggregative activity is characteristic of ibuprofen, as well as other non-steroidal drugs.

Produced in the form of white tablets of an oval form. The tablets "MIG 400" are coated, have a two-sided risk and embossing "E" on both sides. Ibuprofen in each tablet is 400 mg, in addition there are auxiliary agents in the preparation "MIG 400", the instruction indicates the magnesium content of stearate, corn starch, highly disperse silicon dioxide, sodium carboxymethyl starch. The shell consists of the following components: povidone K30, hypromellose, macrogol 4000, titanium dioxide.

Considering the pharmacokinetics of the drug it can be said that there is a good absorption through the GIT of the "MIG 400" preparation, the instruction indicates the maximum content of it in the body after taking in 2 hours, the drug is characterized by 99% binding to plasma proteins, in the synovial fluid is distributed more slowly than In plasma, the same is noted in the derivation.

The kinetics of ibuprofen elimination has 2 phases: a maximum of 3 hours from the plasma, with urine and bile - about 1% unchanged.

There are several indications of the use of the drug "MIG 400", the instruction calls the following cases:

- toothache, headache;

- neuralgia;

- a migraine;

- fever for colds;

- joint, muscle pains.

A detailed list of side effects of the drug "MIG 400", the instruction gives their detailed description according to the effect on individual systems of the body.

Digestive system: heartburn, abdominal pain, vomiting, constipation and diarrhea, flatulence, rarely there is dryness and irritation of the mucosa in the oral cavity.

Respiratory system: bronchospasm and shortness of breath.

Cardiovascular system: tachycardia, heart failure, increased blood pressure.

Sensory organs: blurred vision, decreased hearing, optic nerve damage (toxic), conjunctivitis.

CNS: headache and anxiety, depression and confusion, drowsiness and insomnia;

There may also be complications in the urinary system during the intake of MIG 400, the instruction warns of the possibility of cystitis and acute renal failure, edema and allergic nephritis.

Some allergic reactions are possible in the treatment with MIG 400, the description in the manual contains a warning of skin rash, itching, allergic rhinitis and anaphylactic shock.

At a high dosage and long-term use of the drug "MIG 400", the instruction warns about the danger of impairment of visual function, various types of bleeding (uterine, gastrointestinal, hemorrhoidal), as well as the appearance of ulcers of the gastrointestinal tract.

When choosing the drug "MIG 400" should be careful, because it has a number of contraindications:

- pathology of the digestive tract;

- various bleeding;

- "aspirin triad";

- The age of children under 12 years of age;

- pregnancy and the period of feeding;

- hypersensitivity to ibuprofen;

Great caution should be exercised when:

- arterial hypertension;

- old age;

- heart failure;

- Colitis, gastritis, enteritis;

- Insufficiency - hepatic, renal;

- peptic ulcer and cirrhosis of the liver.

On female fertility, the negative effect of the drug is noted, therefore, the use of "MIG 400" for women planning pregnancy is not recommended.

Dosage of the drug is set individually, usually up to 200 mg per day for adults, if necessary to increase the treatment period, a specialist consultation is necessary.