The drug "Longidase" (injections) - features of the application

The drug "Longidase" (nyxes) is intended only for intramuscular or subcutaneous injections and should not be allowed to enter the blood vessels. It has proteolytic activity, and also has a chelating, antioxidant, anti-inflammatory and immunomodulatory effect.

The use of "Longidase" (injections) prevents the formation of collagen proteins in the fibers, there is also an increase in the permeability of tissue barriers, the elasticity of the connective tissue increases. There is a decrease in edema, joint work improves, the adhesion process is reduced and its appearance is prevented, the scars are flattened.

The medicine "Longidase" (injections) does not have polyclonal and mitogenic activity, it also does not have carcinogenic, teratogenic, embryotoxic and mutagenic effects on the body.

The drug is well absorbed into the bloodstream, and its maximum concentration is noted as early as 25 minutes after administration. Also, the medicine spreads rapidly throughout the body and its half-distribution period is about 30 minutes. From the body said remedy is excreted through the kidneys and its half-life is 42-84 hours.

The drug is intended for complex therapy in the presence of diseases that are accompanied by hyperplasia of connective tissue (it can be performed after reaching the age of 12 years). Also, the medicine "Longidase" is used in the treatment of tuberculosis, pneumofibrosis, alveolitis, chronic interstitial cystitis, tubal peritoneal infertility. This remedy also helps in the presence of trauma, after pyoderma, operations and burns, with hematomas, arthritis and joint contracture.

The drug "Longidase" (injections) - instructions for use

In each individual case, the dose and method of administration of this drug are determined individually and all depends on the patient's age, severity of the disease and many other factors.

Usually subcutaneous or intramuscular injections are done near the affected area in the amount of 3000 IU, the course is from 5 to 15 injections with an interval between their administration from 3 to 10 days, this depends on the severity of the disease. If you need a second course of treatment, you can start it in two to three months.

How to prepare a solution?

To carry out intramuscular or subcutaneous injections, the entire contents of the ampoule must be dissolved in 1.5-2 ml of the procaine solution, it can be either 0.25% or 0.5%. In cases where the body does not tolerate procaine, it can be replaced with 0.9% sodium chloride solution or water for injection.

On cases of overdose with the drug "Longidase" is currently not known.

The medicine "Longidase" can be taken together with antifungal, antihistamine and antiviral drugs, as well as with antibiotics, GCS, cytostatics, bronchodilators.

Joint use of these drugs significantly increases their bioavailability, and when local anesthetics are introduced, analgesia is more rapid. Pregnant women to use the medicine "Longidase" (injections) is contraindicated.

Possible side effects

After the administration of this drug, local reactions such as skin hyperemia, tenderness and swelling of the tissues at the injection site, and allergic reactions can occur. In most cases, all the resulting side effects completely disappear after two or three days.

The drug "Longidase" (injections) - reviews

In general, reviews about this product are only positive. Patients indicate the effectiveness of injections in the treatment of chronic endometritis, as well as after laparoscopy. Some people indicate that they practice mixing this drug with novocaine, which significantly reduces soreness. The negative characteristic of this medication is almost everyone calls a rather pronounced soreness.