HealthPreparations

"Relpaks": the instruction on application, responses. Drug analogues

Migraine, though not a danger to the life of the person suffering from it, but at the same time, significantly reduces the quality of his life. Over the years, the pharmaceutical industry has worked on creating drugs that could eliminate not only the painful symptoms of this disease, but also affect the processes that cause migraines. After all, you can stop pain with strong pain medications. But other symptoms of migraine, such as nausea, photosensitivity and intolerance to sounds, can be difficult to eliminate. In this regard, the specialists from the migraine "Relpax" consider the drug to be one of the most effective. What is this drug? How to take it correctly and what are its analogues? About all this you can read further.

Composition of the preparation, description

The main active substance of the drug "Relpax" - eletriptan in the form of hydrobromide is contained in tablets in the amount of 20 mg. There is also a dosage of 40 mg. Auxiliary substances are widely used in the pharmaceutical industry lactose monohydrate, magnesium stearate, croscarmellose sodium and MCC. These compounds do not affect the ability of the drug to assimilate, and also have no effect on the body as a whole. Migraine tablets "Relpaks" are covered with an orange film membrane that contains titanium dioxide, dyes, lactose monohydrate, hypromellose and triacetin.

Each tablet is made in a round biconvex form. On one side is the engraving "REP 20" or "REP 40" (depending on the amount of active ingredient contained in the tablet) and "Pfizer" on the other. 2, 3, 4, 6 or 10 tablets are placed in one blister, which, in turn, are packed into cardboard packs of 1, 2, 3, 4, 5, 6 or 10 pieces.

Pharmacokinetics and pharmacodynamics

The medicine "Relpaks" is fast enough and is well absorbed after ingestion, especially in combination with fatty foods. The absorption of eletriptan averages about 81%, and the so-called bioavailability is 50%. The maximum content of active substance in the blood plasma is observed after one and a half hours after taking the drug.

The main active substance of the drug "Relpax" has good indices for communication with plasma proteins (about 85%). The primary metabolism of eletriptan occurs in the liver cells. In this case, 2 circulating metabolites are formed, one of which (formed by N-oxidation) does not have activity. The second (formed during the N-demethylation) has almost the same properties as the starting material, but its concentration in the blood plasma is only 10-20% of the eletriptan concentration. Due to this, the active metabolite has no appreciable therapeutic effect.

Tablets from a migraine "Relpaks", reviews of experts about which in the majority the positive, are effective irrespective of a sex of the patient. Derivation of metabolites of the drug is carried out to a greater extent through the kidneys (about 90%), and also through the intestines.

The studies confirmed the absence of the effect of getting used to the main active substance of the drug, so today there are no restrictions on the timing of migraine pain therapy with the help of the Relpax medication.

Regarding the pharmacodynamics of the drug "Relpax" instruction for use mentions the fact that its main active substance, which belongs to the group of selective antagonists of serotonin vascular and neuronal receptors, has an effect on their other species. In this case, the selectivity is manifested more in relation to the receptors localized in the carotid arteries. The antimengnogenic activity of eletriptan causes not only its ability to narrow the blood vessels located inside the skull, but also a positive effect on inflammation of the neurogenic nature. At the same time, the active substance practically does not affect the receptors of the femoral and coronary arteries.

Indications

The drug "Relpax" instruction for use recommends taking with two types of migraine:

  1. With aura, when to severe pain are added such symptoms as visual, tactile, motor, olfactory and auditory disorders.
  2. Without an aura, when in addition to the patient's headache, nausea, vomiting, and increased sensitivity to light and sounds are disturbed.

In the presence of other forms of the disease, the use of this drug not only does not have a positive effect, but can also lead to a number of complications. Therefore, before using this medication to resolve the headache caused by migraine, it is necessary to consult a specialist and undergo a detailed examination. This will help not only to prescribe adequate treatment, but also to eliminate the immediate risk to the patient's health.

Contraindications

Consider a list of contraindications for the use of the drug "Relpax". Tablets, as mentioned above, contain eletriptan, which has the ability of systemic effects on the body and affects many processes. In what cases is the use of the drug unacceptable or undesirable?

  • If there is an increased sensitivity of the patient to all substances that make up the medicinal product;
  • At violations in the work of the liver and kidneys, since the metabolism and excretion of the main active substance occurs precisely in them;
  • With uncontrolled arterial hypertension;
  • With hidden or recently transferred heart diseases, including infarction, angina pectoris, ischemic disease;
  • In the presence of inclusive diseases of peripheral vessels;
  • With transferred or presently transient ischemic attack, as well as with any violations of the cerebral circulation.

The drug "Relpaks" is strongly discouraged from taking persons who are less than 18 years of age. In addition, the drug can not be used to relieve headaches with migraine headaches such as basilar, ophthalmic and hemiplegic.

Application during pregnancy and lactation

The use of "Relpax" during pregnancy has not been studied enough. However, laboratory studies in animals indicate the effect of eletriptan on the developing fetus. First, in embryos, a small number of mutated genes were found (by the principle of polyploidy). Secondly, the weight of the full-term fetus was significantly lower than in animals that did not receive eletriptan during the period of gestation. That is why specialists in his appointment are guided by the rule that the expected benefits for the future mother exceed possible risks for the fetus. It is worth noting that eletriptan, which is part of the drug, is found in breast milk even one day after taking. Therefore, the use of the drug by nursing mothers is possible only with the refusal of breastfeeding for a period of at least 24 hours.

Side effects with the use of Relpax

Concerning the tolerability of the drug "Relpax", experts' reviews contain information on the low severity of side effects that occur independently in a relatively short time. It does not matter what dose (20 or 40 mg) the patient took. The most frequent symptoms observed when taking a drug are:

  • Inflammatory processes in the nasal cavity and pharynx (pharyngitis and rhinitis);
  • Disorders of sensitivity, such as tingling, "creepy";
  • drowsiness;
  • Dizziness or headache;
  • Myasthenia gravis or hypoesthesia;
  • Hypertonicity of muscle fibers;
  • Pain or feeling of squeezing in the back and chest;
  • Violation of the heart rhythm, in particular tachycardia;
  • Dyspepsia, such as pain or discomfort in the abdomen, dry mouth and nausea;
  • Increased sweating;
  • Hot flushes to the face or chills.

Taking into account the chemical composition of "Relpax", specialists do not exclude the development of allergic reactions to the components of the drug, which can be expressed in the appearance of rash, itching or hyperemia. In addition, in rare cases, patients may be troubled by such phenomena as:

  • anorexia;
  • Lymphadenopathy;
  • Confusion, euphoria or depression, insomnia or emotional lability;
  • Photophobia, pain in the eyeball, conjunctivitis, decreased or increased tearing;
  • Violation of taste perception;
  • Ringing or soreness in the ears;
  • Increased blood pressure;
  • Asthmatic attacks;
  • Change voice timbre;
  • Swelling in the mouth;
  • Constipation or diarrhea;
  • Arthritis or arthrosis;
  • Myalgia or myopathy;
  • Polyuria or frequent urination;
  • Violation of the menstrual cycle;
  • Ischemic colitis.

Given the above listed side effects, the use of migraine rempaks is recommended to be performed under the supervision of specialists and only after the necessary studies are carried out for the presence of diseases that may complicate treatment.

Interaction

Let's consider interaction with some medicines of anti-migraine rempaks. The medicine, the instruction to which contains extensive information about its compatibility with other drugs, should not be taken together with the medicines of the following groups:

  • Inhibitors of the isoenzyme, which include "Erythromycin", "Ketoconazole", "Clarithromycin" and "Itraconazole";
  • Protease inhibitors, including "Nelfinavir" and "Indinavir."

Specialists note the fact that simultaneous reception of the drug "Relpax" with drugs "Propanolol" and "Verapamil" can not only provoke a significant increase in blood pressure, but also increase the risk of other side effects. Increased blood pressure can be expected in the case of joint use of the drug with caffeine-containing drugs. That's why experts recommend to observe the daily interval between the methods of such drugs as "Relpax" (analogues also fall under this definition) and ergotamine-like drugs.

It has been clinically proven that the migraine medication referred to in this article does not interact with substances related to beta-blockers, estrogen-containing hormone replacement or oral contraceptives, and also tricyclic antidepressants.

Overdose

If the amount of "Relpax" medicinal product recommended by the attending physician is exceeded, the instructions for use warn of overdose, which can cause a persistent increase in blood pressure and other cardiovascular disorders. When they appear, symptomatic treatment and, if necessary, gastric lavage are recommended.

Mode of application

The drug "Relpax" experts recommend taking with a beginning migraine attack. If the headache and other associated ailments bother the patient for several hours, the drug also maintains its effectiveness. It should be noted that taking a medication as a prophylactic for migraine is not advisable, since it is proved that in this case, it does not have the desired effect. At the same time, with the approaching aura (patients with migraine for a long time can determine this condition), taking the drug not only alleviates the pain that follows the aura, but also stops such symptoms as nausea, drowsiness and photosensitivity. It does not come immediately, but only after the onset of headaches. Therefore, patients with migraine should not rush to drink a pill every time you get sick.

The initial dose of the drug for patients 18-65 years is 40 mg. After relief of migraine, pain can resume. In this case, the instruction advises taking the drug again at the same dosage, but not earlier than 2 hours after the first dose. In case of ineffectiveness of the drug, when the headache does not weaken within 2 hours after the use of the drug, a repeated dose is not recommended. However, specialists point out that the next migraine attack in this patient can be stopped by the initial dose of the drug "Relpax". Comments from consumers on this matter also contain similar information.

The maximum dose of a drug taken within a day should not exceed 160 mg. To drink a pill should be whole, not chewing, squeezed with enough liquid.

special instructions

The use of the drug "Relpaks" is possible only after confirmation of the diagnosis of "migraines". It is due to the fact that with atypical headaches, which can be caused by stroke, rupture of aneurysm and other serious diseases, its reception can provoke various complications. In addition, it is undesirable to use this drug to eliminate severe pain with migraine on the background of cardiovascular diseases and disorders in the functioning of the kidneys and liver, as this can cause the blood pressure to rise to a critical level. The same applies to patients who have a high risk of developing SCD. That is why before the appointment of the drug "Relpaks" the patient must undergo a complete examination. Patients over the age of 65 years at the time of application of the drug should be under the supervision of specialists, since it is they who most often have an increase in blood pressure.

Attention! Regarding the use of the medicine "Relpax", the instructions for use contain references to such side effects as dizziness and drowsiness, so you should take extra care when driving cars and when managing complex equipment.

Analogues of the drug Relpaks, price

Most drugs produced by pharmaceutical companies in the West have domestic counterparts. This can be said about Pfizer, the manufacturer of the drug Relpax. However, since it was registered relatively recently, there are currently no medicines that have the same properties as the Relpax product. Analogues of the main active substance eletriptan are also not known, from which it can be concluded that the drug is unique. The cost of it in Russia is from 380 to 1200 rubles. The specific price depends on how many tablets are in the package and what their dosage is.

According to the method of action on the cerebral vessels of the tablets "Relpax" there are several analogues, which not only differ little from it in value, but are often much more expensive. For example, a medication for migraine "Zomig" can be purchased at a price of about 400 rubles for three tablets. Preparations "Imigran" and "Sumatriptan" are also similar to "Relpax" in terms of the effect and price. The only drug whose cost is much lower than the Relpax tablets is Cofetamine. Their price does not exceed 75 rubles per package.

Reviews about the drug

So, let's move on to the most important question. What do consumers and their attending physicians think about the medicine "Relpax"? What are the pros and cons of this drug? The first thing about which about 80% of respondents say is the high effectiveness of the "Relks" tablets even with a strong migraine attack. According to the patients, after taking just one pill, the pain leaves in 30-40 minutes. About 8% of the consumers surveyed indicated that after using the initial dose of 40 mg they had symptoms such as tremor of the limbs and tingling in the face and hands. However, these unpleasant phenomena passed for two hours without any additional action.

Less than 1% of patients who were prescribed a medicine "Relpaks", at the first reception did not feel its effect at all. At the third of them at repeated attack the preparation has the action, and the others were compelled to find to it replacement.

Specialists note among the merits of the drug its mild effect on the vessels of the head. At the same time, they notice that with the appearance of even the most minor side effects, the patient simply needs to sleep. This will be enough to ensure that all unpleasant events have passed. Specialists also note the following: unlike similar drugs, which do not contain eletriptan, the drug "Relpax" is much more easily tolerated by people with migraine.

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