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Lamivudine: instructions for use, description, composition and reviews

Today, more and more people are hearing a terrible diagnosis - HIV. This pathology has become very common over the past few decades. Antiretroviral therapy is an indispensable condition for prolonging the life of such patients. "Lamivudine," the instructions for use of which will be discussed in detail below, is one of those drugs that are used in combined complex therapy for HIV.

General description and composition

The presented drug is antiviral and is used in complex HIV therapy. Most often the drug is used in the form of white tablets. The most important component of the drug is lamivudine. In one tablet it contains 100 or 300 mg. Among the accompanying components can be identified such: sodium starch glycollate, magnesium stearate, titanium dioxide, hypromelose, polyethylene glycol.

Tablets are manufactured in a shell. The drug is sold in packs of 10, 30 or 60 tablets.

Also, the medicine is produced as a solution for oral administration.

pharmachologic effect

If you need "Lamivudine", the instructions for use (the description you have already considered) speaks about its action: the main substance quickly penetrates the membrane inside the cell and is metabolized. As a result of the reaction, an HIV transcriptase inhibitor appears, which inhibits the multiplication of harmful cells. The drug appears to be highly active towards those strains that are not affected by other drugs.

In addition, the agent exhibits a high activity towards the hepatitis B virus. That is, it can be included in a complex therapy of liver pathologies. However, it should be taken only with the permission of the doctor.

Since the substance is taken orally, its absorption occurs in the gastrointestinal tract. And the level of bioavailability reaches 86%. If you take tablets with food, then note that in this case, the time to reach the highest concentration of the agent in the blood plasma increases.

It goes with the urine unchanged. The main component can partially penetrate into breast milk. It is advisable to stop breastfeeding for the duration of treatment. The half-life of the drug is 3-5 hours.

Indications and contraindications

If you want to buy Lamivudinum, the use of this substance is possible in such cases:

1. During the complex therapy of HIV in children and adults.

2. Viral hepatitis B (chronic form).

However, not everyone is allowed to take this medication. If you are assigned Lamivudine, the instructions for use warn you of the following contraindications:

• Immunity to the components of the drug.

• Poor absorption of lactose.

• Children's age or small body weight. Do not give the drug to a child under 3 years old, as well as those patients whose weight did not reach 14 kg.

• There are problems with the cleansing function of the kidneys (less than 30 ml / min creatinine clearance).

• The period of gestation and feeding of the child.

You should be careful with the use of the drug in such cases:

• The patient is diagnosed with serious kidney failure.

• Neuropathy (peripheral) in an acute form or anamnesis.

• Pancreatitis.

Dosage features, specific indications and drug interactions

To appoint "Lamivudine" (instruction on the use of this drug is attached to each package), only a doctor who has experience in the treatment of HIV can. Eating does not affect the effect of the drug. To divide the tablet into parts is not worth it. It is better to swallow it whole, only in this case the maximum effect can be achieved.

If you need to take the drug Lamivudine, the instructions for use provide for this use: children after three years and adults weighing more than 30 kg, you need to drink 1 tablet (150 g) 2 times a day or 1 capsule (300 mg) 1 time in a day. Children from 2 to 12 years of age are prescribed 3 mg / kg of weight once a day. It is best to listen to the doctor's light. The specialist will prescribe the most optimal dosage, based on your tests, state of health and the severity of the disease.

As for the interaction, we can say the following. For example, with a joint admission with Zidovudine, the duration of the action of the latter increases. But "Zidovudine" does not affect the rate of excretion of "Lamivudine" in any way. Do not take this substance in combination with Zalcitabine, Didanosine and sulfonamides because of the increased risk of developing pancreatitis.

Side effects

No matter how effective Lamivudine is, the instructions for use (the price of the drug is 4000 rubles per package or more) tells about such possible side effects:

1. Infectious pathology of the respiratory system.

2. High degree of fatigue.

3. Pain in the head.

Nausea, vomiting, diarrhea.

5. Increase in the concentration of hepatic enzymes.

6. Decreased appetite.

Independently do not adjust the dose. There is a certain scheme of treatment, which should not be violated.

Analogues, reviews, features of drug storage

If, for some reason, the drug described above does not suit you, you can use analogues. Among them there are: Amiviren, Virolam, Zeffix, Epivir. They have a similar effect.

Shelf life of the drug is 3 years. Keep the product in a place that is protected from light rays. Nearby there should be no heating devices. In addition, it is desirable to remove the drug from the room where there is a high level of humidity.

As for the reviews, they are different. On the one hand, patients note the good effectiveness of the drug in the fight against HIV. On the other hand, they indicate a high risk of side effects. Most often, taking the drug provokes vomiting, severe fatigue. Since the present agent is combined with other antiviral substances, the intensity of undesired reactions may increase. Therefore, prescribe the drug, as well as adjust its dosage is required by the doctor.

Now you have all the information about the medicine Lamivudine. Instructions for use, price, reviews are now known to you. Be healthy!

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