Health, Preparations
Means "Trilon B". Description
The "Trilon B" (disodium salt of ethylenediaminetetraacetic acid) is a crystalline white powder. The drug is soluble in water, almost insoluble in ether and alcohol.
The drug "Trilon B" in medicine
The agent can form various complex compounds with a number of cations, including calcium ions. These properties make it possible to use the drug in pathologies complicated by excessive accumulation of calcium salts in the body (including internal organs, muscles, venous walls), against the background of ossification of the skeleton, arthritis, scleroderma. The agent in some cases is prescribed to eliminate certain types of ectopic arrhythmias, especially those provoked by an overdose of cardiac glycosides. Due to its ability to bind calcium ions, it is also used in the preservation of blood as an anticoagulant.
The drug Trilon B. Application
The main indication for medication is pathology with manifestations of calcification. They include, in particular, scleroderma, dermatomyositis, ossifying myositis. The administration of the drug is carried out intravenously. Before the infusion, the drug is diluted with sodium chloride (isotonic solution) or glucose solution (5%). The preparation "Trilon B" is administered at a rate of up to 12 drops / min. Patients with ten years are recommended to 10 milliliters of a 5% solution, diluted 200 ml of the solvent. The drug is administered in cycles. Patients under 10 years of age are prescribed 5 ml of the drug, diluted in 100 ml of the solvent. The course of therapy includes fifteen injections. The medication is administered once a day for five days with weekly interruptions. Thus, the course includes three five-day cycles with seven-day intervals.
Contraindications and side effects
Not recommended drug "Trilon B" with reduced blood clotting, hemophilia, liver pathologies or kidneys. Contraindications include hypocalcemia. During the introduction at a high rate, the development of tetany is likely. In this case, stop the infusion. Some patients with the introduction of the drug "Trilon B" in the vein feel a burning sensation that can spread throughout the body and persist for one or two hours after the injection.
special instructions
During therapy, it should be noted that the effectiveness of the drug without the appearance of negative consequences is possible at a low rate of introduction into the flow of blood. Under such conditions, the drug slowly interacts with the calcium of the blood serum. In this regard, the content of Ca does not decrease significantly, since its loss is compensated for by mobilization of the compound from the tissues (bone, in particular) and excessive accumulations in the organs. Against the background of rapid drug administration, physiological mechanisms are not able to quickly eliminate the decrease in serum calcium levels. As a result, acute tetany can develop.
How else is Trilon B used?
The remedy is used not only for medicinal purposes. The drug is used in analytical chemistry, for quantitative and qualitative assessment of metal salts. This is made possible by the ability of the substance to form complexion ions with different colors. Ammoniac solution "Trilon B" is used to restore the batteries. This method is characterized by efficiency and high efficiency. Pre-charge the discharged battery, then drain the electrolyte from it and rinse with water two or three times. After it is necessary to pour ammonia solution, which includes two weight percent of the product and five percent ammonia.
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