HealthPreparations

"Lorista": instructions for use, price and reviews. Cheap analog "Lorists"

In order to significantly prolong human life, WHO experts have developed an initiative to combat cardiovascular diseases. The most common pathology from their list is hypertension. It causes damage to the walls of the vessels of the whole body. This is most acutely felt in the brain, heart, kidneys and retina. Therefore, hypertension leads to serious diseases, directly increasing the death rate of the population. Also, due to high blood pressure, patients' quality of life decreases.

Since in the modern world, life expectancy and its quality really are important, then hypertension must be controlled, not allowing a strong and constant increase in pressure. This is achieved through the use of several classes of drugs: ACE inhibitors, blockers of its receptors, calcium antagonists with adrenoblockers and diuretics. These substances form the basis of the treatment of hypertension. And the drug "Lorista", analogs and substitutes, as well as substances similar in effect, remain effective, cost-effective and popular medicines.

General characteristics of the preparation

The drug "Lorista", the substitutes of which are widely represented in the class of antihypertensive drugs, contains losartan. This drug is an angiotensin II receptor blocker. Its therapeutic effect is inhibition of the binding of angiotensin to the endothelial receptor of the vessel, which mediates the inability to contract the vessel. Arterial pressure does not increase, but remains at the initial level. The preparation is made by the Slovenian company KRKA.

It is noteworthy that "Lorista" is a generic, and the original losartan is "Cosaar". But this drug is really qualitative, as it is produced by a company that cares about its positive image. This is proved by the bioequivalence study of "Kozaar" and "Loristas", which confirms the effectiveness of the latter with its proper appointment.

Instructions for use

Attached to the drug "Lorista" instruction, reviews of patients and specialists, as well as clinical trials prove the effectiveness of the drug in the treatment of hypertension. And it is natural that the greatest success of therapy is possible if the recommendations specified in the instructions for use are observed. Among its provisions, the following points are highlighted:

  • A range of indications;

  • Dosage regimens and dose selection;

  • Features of reception;

  • Contraindications;

  • precautionary measures.

For each of the provisions of the instructions for use, read below.

Indications

All indications should be studied in the enclosed instruction, where they are indicated in the form of a list. The purpose of this publication is the isolation of therapeutic windows for the use of the drug. So, "Lorista" is used to treat arterial hypertension of early stages in the monotherapy and in the development of dry cough in response to taking drugs from the group of ACE inhibitors. The latter are considered more effective, whereas "Losartan" is an alternative to them in the development of side effects from their use.

The second indication is the treatment of high-grade hypertension in combination therapy and in patients with high cardiovascular risk. Here its use is also limited by the probability of developing side effects on ACE inhibitors. If there are no side effects, then it is not rational to use Lozartan and other angiotensin receptor blockers, but enzyme inhibitors.

"Lorist" is indicated for the treatment of heart failure in some patients who have seen the escape of the antihypertensive effect from treatment with enzyme inhibitors. Also, in the presence of diabetes "Lozartan", the price of which is quite low, is the drug of choice. However, this is possible with intolerance to ACE inhibitors, which he loses by force of action and the rate of onset of antihypertensive effect.

Dosage regimen and dose selection

Any analogue of "Lorist" is selected strictly individually. There is no and simply can not exist a clear relationship between the degree of hypertension and the dosage of the drug. There may be only some regularities associated with the severity of the course of the underlying disease. With hypertension of the first degree with an already high cardiovascular risk, it is possible to prescribe 12.5 or 25 mg of "Lorist" per day. With increasing the degree of hypertension, dosage also increases.

The drug "Lozartan" price - this is the least important factor in choosing a specific trade name. Only dosage is always important. And it can reach up to 200 mg per day, divided into two doses. The criterion for the effectiveness of treatment is satisfactory levels of blood pressure. When systolic blood pressure does not rise above 140, this dosage is sufficient for therapy.

In the case of development of CHF and absence of hypertension, the appointment of an ACE inhibitor or an ARB is also necessary in order to suppress the processes of myocardial fibrosis. In this case, the drug is administered at the maximum tolerated dose. It is titrated according to the pressure levels, so that it does not fall below 110.

Side effects

The drug "Lorista" affects the biological mechanisms of regulation of pressure, and therefore has some side effects. Some of them are also caused by toxic effects on the liver, the hematopoiesis system. The most frequent, that is, affecting about 1.7% of patients, are side effects: pain in the upper abdomen, fatigue and weakness, development of edema of the face and limbs. For comparison, the frequency of the placebo effect is correlated with the frequency of these side effects, which makes the drug conditionally safe.

"Lorist" is rare, that is, in 1% of cases, causes an increase in heart rate. 2% of patients tend to complain about the development of diarrhea after taking the drug "Losartan". The price of such observations is very low, because the number of such cases is minimal. By the way, even without the drug, but only due to placebo diarrhea and dyspepsia developed in 1.9% of patients.

Rarely, less than 1 case per 100 patients, there is the appearance of pain in the muscles, in the back, the development of muscle cramps. This condition is not classified as myopathy caused by the use of Lozartan. This is only a general reaction, which is also observed in the comparison group. The drug is really well tolerated, much easier than Lorista N and Lorista ND, because their side effects include those that are additionally caused by hydrochlorothiazide. Despite this, all three variants of "Lorist" are safe and important in therapeutic practice.

Contraindications

At all analogues "Loristas" and "Cosaar", including "Lozap", the instruction (the price is indicated below) prohibits application in the following situations:

  • When developing an allergic reaction to any of the drugs containing "Lozartan";

  • Children under 18 years of age because of unproven benefits and the unknown side effects in this category of patients;

  • During pregnancy and lactation.

In patients with existing lesions of the kidneys, the drug "Lorista" can and should be used, as it improves renal blood flow and has a nephroprotective effect. Also, "Losartan" has a slight but useful effect: it accelerates the excretion of uric acid, which slows down the development of exacerbations of gout. However, it is used with caution in liver failure. This clinical condition is considered a relative contraindication.

Reception Features

On the drug "Lorista", "Lozap", "Bloktran", "Cosaar", "Vazotens" the price is different, but the features of the application are similar. In particular, the drug is taken once with a good degree of control of blood pressure or a slight increase in it. If the hypertension is strong with frequent ascent, then the application of "Lozartan" is required twice. It is always advisable to apply the drug at one time, which improves the degree of pressure control and the prognosis of the course of the disease.

The drug "Lorista" can be taken regardless of food, washed down with the right amount of water. At primary appointment its antihypertensive develops gradually, and will reach peak only in 1-2 weeks. In this "Losartan" and other (ARB) angiotensin receptor blockers is significantly inferior to ACE inhibitors. However, the ARB has an important feature - it has no side effect in the form of a dry cough due to the accumulation of bradykinin. Also, ARBs are characterized by the absence of the effect of escaping antihypertensive action, which is typical for long-term use of ACE inhibitors.

Forms of release

"Lorista" is produced in tablets that have a hard shell. Dosages are determined by the mass of "Losartan" present in one tablet. There are three variants of doses of "Lorist": 12.5, 25, 100 mg. Also under this trade name is realized and the combined preparation contains two active substances "Lozartan" and "Hydrochlorothiazide", successfully combined with each other. They are available in the following dosages:

  • 100 mg of losartan + 12.5 mg of hydrochlorothiazide - the drug "Lorista H100";

  • 50 mg losartan + 12.5 mg hydrochlorothiazide - the drug "Lorista N";

  • 100 mg losartan + 25 mg hydrochlorothiazide - the drug "Lorista ND".

In tablets with a similar dosage is sold and any analogue of "Lorist", entering the pharmacy network.

Price "Lorists"

On the drug "Lorista" the price is different in some regions of the country. It depends on the nature of the supply and the admission to implementation. The medicine is always cheaper in those cities where there are centers for examination and testing of drugs. Since each of the medicines, regardless of whether it is imported or domestic, must pass the testing phase of the party, then it is natural that in the country it is cheaper in the capital. In Moscow, 30 tablets of the drug "Lorista" price is as follows:

  • "Lorista 12.5 mg" costs 100-150 rubles;

  • "Lorista 25 mg" costs 160-210 rubles;

  • "Lorista 50 mg" costs 180-270 rubles;

  • "Lorista 100 mg" - 270-330 rubles;

  • "Lorista N" (50 mg) - 250-300 rubles.

The drug "Lorista" from the pressure is packed into 30, 60 and 90 tablets. Patients to whom the drug helps and effectively controls hypertension, you can purchase a large package. This is more economical, because three packs of 30 tablets cost one-third more than one package of 90 tablets.

Cheap analogues of "Loriste"

The company KRKA enjoys the respect of the consumer, because the products it produces meet the clinical requirements. At the same time, their quality is proved by studies of bioequivalence to the original "Losartan" - "Cosaar". However, there are other drugs containing "Lozartan". The drug "Lorista" analogs and substitutes may be cheaper. Examples are Vazotens, Bloktran, Prezartan.

The cheapest analogue is "Bloktran", which is inferior in complexity to the dosage form, but it has a similar efficiency as "Lorista". "Vazotens" is slightly more expensive than "Bloktran", although almost the same in efficiency. The criterion of choice in this case is affordability. Moreover, the drug "Bloktran" indications are identical to those of any analogues containing "Lozartan." This is natural.

Commercial analogues "Loristy"

There are many drugs that contain "Losartan" as an active substance. They differ in different prices and quality. In this case, any analogue of "Lorist", except for the drug "Cosaar", is a generic. "Lorista" is also a licensed copy of the original "Losartan" - the drug "Cosaar". Therefore, as a basis of comparison for price and efficiency, it is rational to take exactly the original medicine produced by the Swiss company MERCK SHARP & DOHME IDEA, Inc. Among the commercial counterparts "Loristy" there are preparations of three price categories:

  • With a higher price ("Kozaar", "Amzaar", "Gizaar");

  • With approximately the same price ("Lozartan-Teva", "Lozap", "Lorista", "Centor");

  • Cheaper drugs (Lozartan NAN, Lozartan-Richter, Lozartan Belmedpreparaty, Prezartan, Bloktran, Vazotens).

The price of preparations of the first category fluctuates within the limits of 500-1000 rubles for packing in 30 tablets with the content of "Losartan" 100 and 50 mg. Combined preparations containing 25 or 12.5 mg of "hydrochlorothiazide" together with 100 or 50 mg of "Losartan", respectively, cost about 800-1000 rubles for 30 tablets.

Preparations of the average price category approximately correspond to the price of "Loriste". Any specified analogue of "Lorist" fits in the price range of 300-600 rubles, depending on the dosage and combination with "Hydrochlorothiazide". And drugs of the lower price range cost up to 300 - 400 rubles, which are needed for a monthly treatment course.

The most economically advantageous is the drug "Lorista", "Centor", "Lozap", "Losartan NAN". Among the affordable alternatives are the best medicines. An unconditional favorite among any derivatives of "Losartan" - the drug "Cosaar", which is original. With its use, the effectiveness of "Losartan" as an antihypertensive substance has been proven.

Expert Reviews

The specialists treat the drug "Lorista" rather well, because its effectiveness is proved in the bioequivalence study "Kozaaru". Because it is commonly believed that "Lorista" is a cheaper original "Cosaar". Positive feedback from specialists was earned due to the lack of the effect of escaping antihypertensive action. However, the drug also has drawbacks inherent in the whole class of angiotensin receptor blockers. Their effect is slower, which prevents to immediately begin to treat high-grade arterial hypertension or to apply the drug for crises.

Patient Reviews

With constant admission, patients note a small number of side effects, virtually no different from the statistical indicators stated in the attached instructions. The drug is good and uniformly controls blood pressure, which significantly reduces the likelihood of crises. Also, male patients note that "Lorista" does not reduce potency, as it happens with ACE inhibitors. In general, "Lorista" is characterized as a reliable and safe treatment for hypertension.

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