"Finoptin": instructions for use, composition, testimonials, analogues

Many people suffer from diseases of the heart and blood vessels. Moreover, with age, the risk of such pathological conditions increases significantly. To reduce the likelihood of development of serious processes in the body, doctors recommend using special means. Among them, calcium channel blockers are especially popular . They belong to a heterogeneous group of medicines. Their mechanism of action is related to the ability to inhibit the penetration of Ca ions from the intercellular space into the cells of the vessels and the heart. Reducing the concentration of these elements, the drug has a vasodilating effect.

The most effective drug with such properties is "Finoptin". Instructions for use, composition, analogs, indications for the use of the drug and its side effects are described below.

Form, composition

What form is typical for the medicine "Finoptin"? Instructions for use say that it can be purchased in the form of injection solution and tablets.

As the active ingredient of this drug is verapamil hydrochloride. Also, the composition of the drug includes various auxiliary compounds (depending on the form of release).

pharmachologic effect

What features are inherent in the preparation "Finoptin"? Instructions for use, reviews claim that this is a calcium channel blocker (selective) of the first class. It is a derivative of diphenylalkylamine, and also exhibits antianginal, antihypertensive and antiarrhythmic action.

The antianginal effect of this drug is related to its ability to influence the myocardium and peripheral hemodynamics. In other words, this drug reduces the tone of the arteries. In addition, it reduces the transformation of ATP energy, which is enclosed in macroergic bonds, into mechanical work and contributes to a decrease in myocardial contractility.

It should also be noted that the use of this drug significantly reduces the need for myocardium in O2, and also has a negative chrono-, inotropic and vasodilating effect.

Properties of the preparation

Due to its composition, the medication "Finoptin", analogues of which are listed below, suppresses the automaticity of the sinus node, reduces AV-conduction and increases the period of refractoriness.

By increasing the time of diastolic relaxation of the ventricle (left), this drug significantly reduces the tone of the walls of the myocardium, that is, it is an auxiliary tool for the treatment of obstructive hypertrophic cardiomyopathy.

It should also be noted that the drug in question exhibits antiarrhythmic properties in supraventricular arrhythmias.

Kinetics of medicament

The drug "Finoptin", the instruction of which is described below, is absorbed from the digestive tract (about 90% of the dose taken). Its connection with proteins is 90%.

The drug is metabolized during passage (first) through the liver. This produces a derivative such as norverapamil, which has less hypotensive activity than unchanged verapamil.

The half-life of the drug with a single dose is 3-8 hours. When you use repeated doses of medication, this indicator varies (5-12 hours).

Drug is given through the intestines and kidneys.

Indications

In what cases is the medicine "Finoptin" prescribed? Instructions for use (tablets and injections have the same ostentatious) states that this remedy can be used for supraventricular tachycardia (including paroxysmal, Laun-ganong-levin syndrome and WPW syndrome), angina (tension stable without Angiospasm, stable vasospastic), sinus tachycardia, atrial flutter, ciliary tachyarrhythmia, atrial extrasystole, hypertensive crisis (for intravenous administration), arterial hypertension, primary hypertension in a small bowl in circulation, hypertrophic obstructive cardiomyopathy.

Contraindications

When should you not prescribe the medicine "Finoptin"? Instructions for use (injections and tablets have the same contraindications) indicates that this drug is prohibited for use in severe arterial hypotension, sinoatrial blockade and SSSU (except for patients with a pacemaker), AV blockade of the third and second degree, Laune syndrome -Ganong-Levin and WPW-syndrome in combination with atrial fibrillation or flutter (except for sick people with a pacemaker), pregnancy, hypersensitivity to verapamil, breastfeeding.

Preparation "Finoptin": instructions for use

The dosage of this drug is calculated by the doctor individually.

For adult patients, tablets are given orally at an initial dose of 40-80 mg three times a day. For dosage forms with prolonged action, a single dosage should be increased and the frequency of administration reduced.

Babies aged 6-14 years, this medication is recommended to take in the amount of 80-360 mg per day, and up to 6 years - in a dose of 40-60 mg per day. The frequency of taking this medication is four times a day.

If necessary, the drug in question can be injected intravenously (slowly). Thus it is necessary to supervise an electrocardiogram, arterial pressure and heart rate of the patient.

Single dose solution for adults is 5-10 mg. If the therapeutic effect is absent, then after 20 minutes the drug can be re-introduced (in the same dose).

One-time dosage of the injectable form of the drug for children 6-14 years is 2.5-3.5 mg, for children 1-5 years - 2-3 mg, and for a child up to one year - 0.75-2 mg.

Patients with severe disruption of the liver daily dose should not be more than 120 mg.

The maximum dosage of oral preparation per day is 480 mg.

Side effects

The drug "Finoptin" can provoke the appearance of the following adverse reactions:

• Weight gain, bradycardia, agranulocytosis, aggravation or development of heart failure, hyperprolactinaemia, tachycardia, transient loss of vision, peripheral edema;
• Pronounced decrease in blood pressure, gynecomastia, galactorrhea, arthritis, angina pectoris, arrhythmia, pulmonary edema, AV-blockade of the third degree, asystole, thrombocytopenia asymptomatic, collapse;
• Nausea, stiffness of hands or feet, gingival hyperplasia, fainting, increased fatigue, increased appetite, anxiety, increased activity of liver transaminases;
• Skin rash, dizziness, constipation or diarrhea, headache, depression, inhibition, extrapyramidal disorders, asthenia, skin hyperemia, drowsiness, erythema multiforme exudative, itching.

Drug Interactions

Can I combine the medicine "Finoptin" with other medicines? Instructions for use say that the combination of this drug with antihypertensive drugs mutually reinforces their antihypertensive effect.

With the intravenous administration of verapamil to people who have recently received a dose of beta-blockers, there is a high risk of developing hypotension (arterial) and asystole.

With the joint administration of the drug "Finoptin" with beta-blockers, drugs for inhalation anesthesia and antiarrhythmic drugs, the risk of developing heart failure, bradycardia, severe arterial hypotension and AV blockade increases.

With simultaneous reception with Amiodarone, bradycardia, negative inotropic action, AV blockade and conduction disturbance are increased.

In view of the fact that verapamil inhibits the CYP3A4 isoenzyme involved in the metabolism of simvastatin, lovastatin and atorvastatin, some manifestations of interaction are possible that are caused by an increase in the concentration of statins in the blood. There are also cases of rhabdomyolysis.

When combined with nitrates, the antianginal properties of "Finoptina" increase.

With the simultaneous administration of an acetylsalicylic acid, the time of bleeding increases due to an antiaggregant additive effect.

Can I take "Dizopiramid" in conjunction with the drug "Finoptin"? Instruction for use informs that such combination can lead to severe arterial hypotension and collapse, especially in people with decompensated heart failure or cardiomyopathy.

With the simultaneous use of tablets and a solution with "Imipramine", its concentration in the blood increases, as a result of which there is a risk of undesirable changes on the ECG. It should also be noted that verapamil increases the bioavailability of "Imipramine", reducing its clearance.

When the drug is combined with "Carbamazepine", the effect of the latter increases, and the risk of side effects from the CNS increases.

With the simultaneous administration of the drug with "Clonidine" there are cases of cardiac arrest in people with arterial hypertension.

When combining a medicine with lithium carbonate, the manifestations of drug interaction are unpredictable and ambiguous. There are cases of neurotoxicity, severe bradycardia, increased lithium effects and a decrease in its concentration in the blood.

How does Rifampicin affect Finoptin? The instruction asserts that such a combination induces the activity of hepatic enzymes, accelerating the metabolism of verapamil. Ultimately, this leads to a decrease in the clinical effectiveness of the drug in question.

Special Recommendations

What should I know before using the medication "Finoptin" (40 mg)? The instruction says that this remedy is used with caution in AV blockade of the first degree, severe stenosis of the aortic aorta, bradycardia, myocardial infarction with left ventricular failure, chronic heart failure, mild or mild arterial hypotension, hepatic or renal insufficiency. Also, this medicine is cautiously recommended to elderly people and minor children.

In acute circumstances, it is permitted to carry out combined therapy of arterial hypertension and angina by means of verapamil and beta-adrenoblockers. However, it is necessary to avoid intravenous administration of the latter.

After taking this medication, the patient may develop such individual reactions as drowsiness and dizziness that can affect a person's ability to perform hazardous activities.

Lactation and pregnancy

Is it possible to prescribe the drug "Finoptin" for pregnant women? Instructions for use during pregnancy states that this drug has a negative effect on the development of the fetus. It also penetrates into breast milk. Therefore, with such conditions, this drug is strictly contraindicated.

Medication "Finoptin": analogues and cost

The price of this tool can be different. As a rule, it depends on the form of release of the drug, its quantity or volume. The average cost of "Finoptina" is 100-170 rubles.

If this drug is contraindicated to you, then it can be replaced by one of the following means: Verapamil, Veragalide, Verapamil-OBL, Kaveril, Verapamil Sopharma, Verapamil-LekT, Verapamil-Ferein, Verapamil Ratiofarm, Isoptin, Verapamil-Eskom, Vero-Verapamil, Verapamil Hydrochloride, and Lekoptin.

Reviews of doctors and consumers

Experts argue that the tablets and solution "Finoptin" are effective and inexpensive means that are designed to restore blood pressure, as well as improve your health in other diseases of the heart and blood vessels.

As for patients, most of them are quite enough with the results of treatment with this remedy. Receiving tablets or intravenous fluids helps to quickly eliminate the symptoms of hypertension and other signs of diseases of the cardiovascular system.

It should also be noted that negative messages are also found about this medicine. They talk about a large number of adverse reactions that occur immediately after using the medication. Also, many consumers complain about a lot of contraindications.